Determination of ximelagatran, melagatran and two intermediary metabolites in plasma by mixed-mode solid phase extraction and LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 317-324

  Dunér, Kristina ^a   Bäckström, Jonas ^a   Magnell, Niklas ^a   Svennberg, Henrik ^a   Ahnoff, Martin ^a   Logren, Ulrika ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Mixed mode solid phase extraction; Thrombin inhibitor

Indexed keywords

ELECTROSPRAY IONIZATION MASS SPECTROMETRY; MELAGATRAN; THROMBIN INHIBITOR; XIMELAGATRAN;

ACETIC ACID; ACETONITRILE; IONIC STRENGTH; PLASMA (HUMAN); PROTEINS; SOLVENT EXTRACTION;

DRUG PRODUCTS;

ACETIC ACID; ACETONITRILE; ALBUMIN; AMMONIUM ACETATE; DRUG METABOLITE; ETHYL MELAGATRAN; FORMIC ACID; MELAGATRAN; METHANOL; OH MELAGATRAN; UNCLASSIFIED DRUG; XIMELAGATRAN;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

ANTICOAGULANTS; ANTITHROMBINS; AZETIDINES; BENZYLAMINES; CALIBRATION; CHROMATOGRAPHY, LIQUID; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 34249678654     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.01.035     Document Type: Article

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