Development of high-performance liquid chromatography-tandem mass spectrometric methods for the determination of a new oxytocin receptor antagonist (L-368,899) extracted from human plasma and urine: A case of lack of specificity due to the presence of metabolites

Journal of Chromatography B: Biomedical Applications

Volumn 716, Issue 1-2, 1998, Pages 195-208

  Matuszewski, B K ^a   Chavez Eng, C M ^a   Constanzer, M L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

L 368,899; Oxytocin

Indexed keywords

1 [[[2 [2 AMINO 4 (METHYLSULFONYL)BUTYRAMIDO] 7,7 DIMETHYLBICYCLO[2.2.1]HEPTAN 1 YL]METHYL]SULFONYL] 4 (2 METHYLPHENYL)PIPERAZINE; OXYTOCIN ANTAGONIST; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BLOOD ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; URINALYSIS;

ANIMALS; BORNANES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; MASS SPECTROMETRY; PIPERAZINES; QUALITY CONTROL; RECEPTORS, OXYTOCIN; SENSITIVITY AND SPECIFICITY; TRIFLUOROACETIC ACID;

EID: 0032566565     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00317-X     Document Type: Article

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