메뉴 건너뛰기




Volumn 52, Issue 3, 2008, Pages 247-259

Tumor vasculature as a therapeutic target in non-small cell lung cancer;A daganatos érhálózat mint terápiás célpont nem kissejtes tüdorákban

Author keywords

Angiogenesis; Lung cancer

Indexed keywords

4 ((4 FLUORO 2 METHYL 1H INDOL 5 YL)OXY) 6 METHOXY 7 (3 (PYRROLIDIN 1 YL)PROPOXY)QUINAZOLINE; 4-((4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY)-6-METHOXY-7-(3-(PYRROLIDIN-1-YL)PROPOXY)QUINAZOLINE; 5,6 DIMETHYLXANTHENONEACETIC ACID; 5,6-DIMETHYLXANTHENONEACETIC ACID; AFLIBERCEPT; ANGIOGENESIS INHIBITOR; AXITINIB; BENZENESULFONIC ACID DERIVATIVE; BEVACIZUMAB; DRUG DERIVATIVE; HYBRID PROTEIN; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MONOCLONAL ANTIBODY; MOTESANIB; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 ((1 METHYLPIPERIDIN 4 YL)METHOXY)QUINAZOLIN 4 AMINE; N [2 [(4 HYDROXYPHENYL)AMINO] 3 PYRIDINYL] 4 METHOXYBENZENESULFONAMIDE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; NICOTINAMIDE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SORAFENIB; SULFONAMIDE; TUMOR MARKER; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

EID: 58149235293     PISSN: 00250244     EISSN: 20600399     Source Type: Journal    
DOI: 10.1556/MOnkol.52.2008.3.2     Document Type: Article
Times cited : (6)

References (123)
  • 1
    • 0345276632 scopus 로고    scopus 로고
    • Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
    • Aicher A, Heeschen C, Mildner-Rihm C, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 9:1370-1376, 2003
    • (2003) Nat Med , vol.9 , pp. 1370-1376
    • Aicher, A.1    Heeschen, C.2    Mildner-Rihm, C.3
  • 2
    • 45449113946 scopus 로고    scopus 로고
    • Targeting egfr activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in vegfr-2 dependence in tumor endothelial cells
    • 18 Mar, Epub ahead of print
    • Amin DN, Bielenberg DR, Lifshits E, et al. Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells. Microvasc Res 18 Mar, 2008 (Epub ahead of print)
    • (2008) Microvasc Res
    • Amin, D.N.1    Bielenberg, D.R.2    Lifshits, E.3
  • 3
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-967, 1997
    • (1997) Science , vol.275 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3
  • 4
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 15:102-111, 2005
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 5
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golffanin D, Itin A, et al. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 103:159-165, 1999
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golffanin, D.2    Itin, A.3
  • 6
    • 0036118399 scopus 로고    scopus 로고
    • Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
    • Bonomi P. Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer. Semin Oncol 29:78-86, 2002
    • (2002) Semin Oncol , vol.29 , pp. 78-86
    • Bonomi, P.1
  • 7
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kräling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60:1878-1886, 2000
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kräling, B.M.3
  • 8
    • 34147131736 scopus 로고    scopus 로고
    • Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: Rationale and clinical applications for non-small-cell lung cancer
    • Byers LA, Heymach JV. Dual targeting of the vascular endothelial growth factor and epidermal growth factor receptor pathways: rationale and clinical applications for non-small-cell lung cancer. Clin Lung Cancer 8(Suppl 2):S79-85, 2007
    • (2007) Clin Lung Cancer , vol.8 , Issue.SUPPL. 2
    • Byers, L.A.1    Heymach, J.V.2
  • 9
    • 0032950870 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin a4 phosphate
    • Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate. Anticancer Res 19:189-195, 1999
    • (1999) Anticancer Res , vol.19 , pp. 189-195
    • Chaplin, D.J.1    Pettit, G.R.2    Hill, S.A.3
  • 10
    • 0037314662 scopus 로고    scopus 로고
    • Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
    • Chen JJ, Yao PL, Yuan A, et al. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 9:729-737, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 729-737
    • Chen, J.J.1    Yao, P.L.2    Yuan, A.3
  • 11
    • 0032787305 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (vegf) and its two receptors (vegf-r1-flt1 and vegf-r2-flk1/kdr) in non-small cell lung carcinomas (nsclcs): Correlation with angiogenesis and survival
    • Decaussin M, Sartelet H, Robert C, et al. Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF-R1-Flt1 and VEGF-R2-Flk1/KDR) in non-small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival. J Pathol 188:369-377, 1999
    • (1999) J Pathol , vol.188 , pp. 369-377
    • Decaussin, M.1    Sartelet, H.2    Robert, C.3
  • 12
    • 3242803674 scopus 로고    scopus 로고
    • Benefits of adding a drug to a single-Agent or a 2-Agent chemotherapy regimen in advanced non-small-cell lung cancer: A meta-Analysis
    • Delbaldo C, Michiels S, Syz N, et al. Benefits of adding a drug to a single-Agent or a 2-Agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-Analysis. JAMA 292:470-484, 2004
    • (2004) JAMA , vol.292 , pp. 470-484
    • Delbaldo, C.1    Michiels, S.2    Syz, N.3
  • 13
    • 0036808541 scopus 로고    scopus 로고
    • Vegf and survival of patients with lung cancer: A systematic literature review and metaanalysis
    • Delmotte P, Martin B, Paesmans M, et al. VEGF and survival of patients with lung cancer: a systematic literature review and metaanalysis. Rev Ma Respir 19:577-584, 2002
    • (2002) Rev Ma Respir , vol.19 , pp. 577-584
    • Delmotte, P.1    Martin, B.2    Paesmans, M.3
  • 14
    • 40049087424 scopus 로고    scopus 로고
    • Circulating bone marrow-derived endothelial progenitor cells: Characterization, mobilization, and therapeutic considerations in malignant disease
    • Dome B, Dobos J, Tovari J, et al. Circulating bone marrow-derived endothelial progenitor cells: Characterization, mobilization, and therapeutic considerations in malignant disease. Cytometry A 73:186-193, 2008
    • (2008) Cytometry A , vol.73 , pp. 186-193
    • Dome, B.1    Dobos, J.2    Tovari, J.3
  • 15
    • 33847048710 scopus 로고    scopus 로고
    • Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
    • Dome B, Hendrix MJ, Paku S, et al. Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. Am J Pathol 170:1-15, 2007
    • (2007) Am J Pathol , vol.170 , pp. 1-15
    • Dome, B.1    Hendrix, M.J.2    Paku, S.3
  • 16
    • 33746906996 scopus 로고    scopus 로고
    • Identification and clinical signifi-cance of circulating endothelial progenitor cells in human nonsmall cell lung cancer
    • Dome B, Timar J, Dobos J, et al. Identification and clinical signifi-cance of circulating endothelial progenitor cells in human nonsmall cell lung cancer. Cancer Res 66:7341-7347, 2006
    • (2006) Cancer Res , vol.66 , pp. 7341-7347
    • Dome, B.1    Timar, J.2    Dobos, J.3
  • 17
    • 34247509357 scopus 로고    scopus 로고
    • Prospective correlative assessment of biomarkers in e4599 randomized phase ii/iii trial of carboplatin and paclitaxel + bevacizumab in advanced non-small cell lung cancer (nsclc
    • Dowlati A, Gray R, Johnson DH, et al. Prospective correlative assessment of biomarkers in E4599 randomized phase II/III trial of carboplatin and paclitaxel + bevacizumab in advanced non-small cell lung cancer (NSCLC). J Clin Oncol 24S:7027, 2006
    • (2006) J Clin Oncol , vol.24 S , pp. 7027
    • Dowlati, A.1    Gray, R.2    Johnson, D.H.3
  • 18
    • 20944441692 scopus 로고    scopus 로고
    • Soluble markers for the assessment of biological activity with ptk787/zk 222584 (ptkzk) a vascular endothelial growth factor receptor (vegfr) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase i trials
    • Drevs J, Zirrgiebel U, Schmidt-Gersbach CI, et al. Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials. Ann Oncol 16:558-565, 2005
    • (2005) Ann Oncol , vol.16 , pp. 558-565
    • Drevs, J.1    Zirrgiebel, U.2    Schmidt-Gersbach, C.I.3
  • 19
    • 34748921698 scopus 로고    scopus 로고
    • Antiangiogenics: The potential role of integrating this novel treatment modality with chemoradiation for solid cancers
    • Duda DG, Jain RK, Willett CG. Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol 25:4033-4042, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 4033-4042
    • Duda, D.G.1    Jain, R.K.2    Willett, C.G.3
  • 20
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am 18:1007-1021, 2004
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 1007-1021
    • Ellis, L.M.1
  • 21
    • 0032944435 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor mrna in non-small-cell lung carcinomas
    • Fontanini G, Boldrini L, Chinè S, et al. Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas. Br J Cancer 79:363-369, 1999
    • (1999) Br J Cancer , vol.79 , pp. 363-369
    • Fontanini, G.1    Boldrini, L.2    Chinè, S.3
  • 22
    • 0030969559 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma
    • Fontanini G, Vignati S, Boldrini L, et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 3:861-865, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 861-865
    • Fontanini, G.1    Vignati, S.2    Boldrini, L.3
  • 23
    • 33748372759 scopus 로고    scopus 로고
    • A phase 1 study of abt-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors
    • Fox E, Maris JM, Widemann BC, et al. A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors. Clin Cancer Res 12:4882-4887, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 4882-4887
    • Fox, E.1    Maris, J.M.2    Widemann, B.C.3
  • 24
    • 0037950271 scopus 로고    scopus 로고
    • Small peripheral pulmonary carcinomas evaluated with dynamic mr imaging: Correlation with tumor vascularity and prognosis
    • Fujimoto K, Abe T, Müller NL, et al. Small peripheral pulmonary carcinomas evaluated with dynamic MR imaging: correlation with tumor vascularity and prognosis. Radiology 227:786-793, 2003
    • (2003) Radiology , vol.227 , pp. 786-793
    • Fujimoto, K.1    Abe, T.2    Müller, N.L.3
  • 25
    • 33750701818 scopus 로고    scopus 로고
    • Relationship between cancer cell proliferation, tumour angiogenesis and 201tl uptake in nonsmall cell lung cancer
    • Fujita S, Nagamachi S, Nishii R, et al. Relationship between cancer cell proliferation, tumour angiogenesis and 201Tl uptake in nonsmall cell lung cancer. Nucl Med Commun 27:989-997, 2006
    • (2006) Nucl Med Commun , vol.27 , pp. 989-997
    • Fujita, S.1    Nagamachi, S.2    Nishii, R.3
  • 26
    • 33344459620 scopus 로고    scopus 로고
    • Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer
    • Furstenberger G, von Moos R, Lucas R, et al. Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br J Cancer 94:524-531, 2006
    • (2006) Br J Cancer , vol.94 , pp. 524-531
    • Furstenberger, G.1    Von Moos, R.2    Lucas, R.3
  • 27
    • 35748963560 scopus 로고    scopus 로고
    • Tumor targeting with rgd peptide ligands-design of new molecular conjugates for imaging and therapy of cancers
    • Garanger E, Boturyn D, Dumy P. Tumor targeting with RGD peptide ligands-design of new molecular conjugates for imaging and therapy of cancers. Anticancer Agents Med Chem 7:552-558, 2007
    • (2007) Anticancer Agents Med Chem , vol.7 , pp. 552-558
    • Garanger, E.1    Boturyn, D.2    Dumy, P.3
  • 28
    • 33748913369 scopus 로고    scopus 로고
    • Phase ii trial of single-Agent sorafenib in patients with advanced non-small cell lung carcinoma
    • Gatzemeier U, Blumenschein G, Fosella F, et al. Phase II trial of single-Agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol 24:18S:7002, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 7002
    • Gatzemeier, U.1    Blumenschein, G.2    Fosella, F.3
  • 29
    • 33746565515 scopus 로고    scopus 로고
    • Role of raf kinase in cancer: Therapeutic potential of targeting the raf/mek/erk signal transduction pathway
    • Gollob JA, Wilhelm S, Carter C, Kelley SL. Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol 33:392-406, 2006
    • (2006) Semin Oncol , vol.33 , pp. 392-406
    • Gollob, J.A.1    Wilhelm, S.2    Carter, C.3    Kelley, S.L.4
  • 30
    • 0035253739 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 19:843-850, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 31
    • 35948990764 scopus 로고    scopus 로고
    • Phase i study of daily oral azd2171, a vascular endothelial growth factor receptor inhibitor (vegfri), in combination with gemcitabine and cisplatin (g/c) in patients with advanced non-small cell lung cancer (ansclc): A study of the ncic clinical trials group
    • Goss GD, Laurie S, Shepherd F, et al. Phase I study of daily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced non-small cell lung cancer (ANSCLC): A study of the NCIC Clinical Trials Group. J Clin Oncol 25(18S):7649, 2007
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 7649
    • Goss, G.D.1    Laurie, S.2    Shepherd, F.3
  • 32
    • 33750603100 scopus 로고    scopus 로고
    • Changing epidemiology of small-cell lung cancer in the united states over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database
    • Govindan R, Page N, Morgensztern D, et al. Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 24:4539-4544, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 4539-4544
    • Govindan, R.1    Page, N.2    Morgensztern, D.3
  • 33
    • 33645991547 scopus 로고    scopus 로고
    • Microvessel density: Correlation with 18f-fdg uptake and prognostic impact in lung adenocarcinomas
    • Guo J, Higashi K, Ueda Y, et al. Microvessel density: correlation with 18F-FDG uptake and prognostic impact in lung adenocarcinomas. J Nucl Med 47:419-425, 2006
    • (2006) J Nucl Med , vol.47 , pp. 419-425
    • Guo, J.1    Higashi, K.2    Ueda, Y.3
  • 34
    • 42049096107 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab for metastatic breast cancer
    • Haines IE, Miklos GL, Rossi A, et al. Paclitaxel plus bevacizumab for metastatic breast cancer. N Eng J Med 358:1637-1638, 2008
    • (2008) N Eng J Med , vol.358 , pp. 1637-1638
    • Haines, I.E.1    Miklos, G.L.2    Rossi, A.3
  • 35
    • 0035155064 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in stage i non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis
    • Han H, Silverman JF, Santucci TS, et al. Vascular endothelial growth factor expression in stage I non-small cell lung cancer correlates with neoangiogenesis and a poor prognosis. Ann Surg Oncol 8:72-79, 2001
    • (2001) Ann Surg Oncol , vol.8 , pp. 72-79
    • Han, H.1    Silverman, J.F.2    Santucci, T.S.3
  • 36
    • 33646741205 scopus 로고    scopus 로고
    • The pharmacokinetics and safety of abt-751, a novel, orally bioavailable sulfonamide antimitotic agent: Results of a phase 1 study
    • Hande KR, Hagey A, Berlin J, et al. The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin Cancer Res 12:2834-2840, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 2834-2840
    • Hande, K.R.1    Hagey, A.2    Berlin, J.3
  • 37
    • 36048982143 scopus 로고    scopus 로고
    • Phase ii study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer
    • Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 25:4743-4750, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3
  • 38
    • 35948978403 scopus 로고    scopus 로고
    • Randomized phase ii study of vandetanib alone or in combination with carboplatin and paclitaxel as first-line treatment for advanced non-small cell lung cancer (nsclc
    • Heymach J, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or in combination with carboplatin and paclitaxel as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 25(18S):7544, 2007
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 7544
    • Heymach, J.1    Paz-Ares, L.2    De Braud, F.3
  • 39
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebocontrolled phase ii study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach JV, Johnson BE, Prager D, et al. Randomized, placebocontrolled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 25:4270-4277, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 40
    • 4444251520 scopus 로고    scopus 로고
    • Cd133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer
    • Hilbe W, Dirnhofer S, Oberwasserlechner F, et al. CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer. J Clin Pathol 57:965-969, 2004
    • (2004) J Clin Pathol , vol.57 , pp. 965-969
    • Hilbe, W.1    Dirnhofer, S.2    Oberwasserlechner, F.3
  • 41
    • 0036570203 scopus 로고    scopus 로고
    • Zd1839 (iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A, Ogawa S, Kometani T, et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 62:2554-2560, 2002
    • (2002) Cancer Res , vol.62 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.2    Kometani, T.3
  • 42
    • 33750621103 scopus 로고    scopus 로고
    • Significance of circulating endothelial progenitor cells in hepatocellular carcinoma
    • Ho JW, Pang RW, Lau C, et al. Significance of circulating endothelial progenitor cells in hepatocellular carcinoma. Hepatology 44:836-843, 2006
    • (2006) Hepatology , vol.44 , pp. 836-843
    • Ho, J.W.1    Pang, R.W.2    Lau, C.3
  • 43
    • 84875140196 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00073151?term=ABT- 751+lung&rank=2
  • 44
    • 84875191704 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00113438?term=ca4p&rank=1
  • 45
    • 84875157149 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00297089?term=ABT- 751+lung&rank=3
  • 46
    • 84875201343 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00354562?term=ABT- 751+lung&rank=1
  • 47
    • 84875128634 scopus 로고    scopus 로고
    • http://www.gene.com/gene/news/press-releases/display.do?meth od=detail&id=11207
  • 48
    • 84875139097 scopus 로고    scopus 로고
    • http://www.press.bayer.com/baynews/baynews.nsf/id/ 7F2163C8C6C18519C12573F30051050E?Open&ccm=001
  • 49
    • 20044370800 scopus 로고    scopus 로고
    • Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer
    • Hu J, Bianchi F, Ferguson M, et al. Gene expression signature for angiogenic and nonangiogenic non-small-cell lung cancer. Oncogene 24:1212-1219, 2005
    • (2005) Oncogene , vol.24 , pp. 1212-1219
    • Hu, J.1    Bianchi, F.2    Ferguson, M.3
  • 50
    • 23444435294 scopus 로고    scopus 로고
    • Clinical implications of antiangiogenic therapies
    • Hudis CA. Clinical implications of antiangiogenic therapies. Oncology (Williston Park) 19(4 Suppl 3):26-31, 2005
    • (2005) Oncology (Williston Park , vol.19 , Issue.4 SUPPL. 3 , pp. 26-31
    • Hudis, C.A.1
  • 51
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 52
    • 34547650991 scopus 로고    scopus 로고
    • Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients
    • Igreja C, Courinha M, Cachaco AS, et al. Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients. Haematologica 92:469-477, 2007
    • (2007) Haematologica , vol.92 , pp. 469-477
    • Igreja, C.1    Courinha, M.2    Cachaco, A.S.3
  • 53
    • 1542719213 scopus 로고    scopus 로고
    • Basic fibroblast growth factor (bfgf) and vascular endothelial growth factor (vegf) levels, as prognostic indicators in nsclc
    • Iwasaki A, Kuwahara M, Yoshinaga Y, Shirakusa T. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) levels, as prognostic indicators in NSCLC. Eur J Cardiothorac Surg 25:443-448, 2004
    • (2004) Eur J Cardiothorac Surg , vol.25 , pp. 443-448
    • Iwasaki, A.1    Kuwahara, M.2    Yoshinaga, Y.3    Shirakusa, T.4
  • 54
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-Angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-Angiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989, 2001
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 55
    • 30944446883 scopus 로고    scopus 로고
    • Loeffler js. Lessons from phase iii clinical trials on anti-vegf therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 3:24-40, 2006
    • (2006) Nat Clin Pract Oncol , vol.3 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3
  • 56
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase ii trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 22:2184-2191, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 57
    • 0037208589 scopus 로고    scopus 로고
    • Phase ii, randomized trial comparing bevacizumab plus fluorouracil (fu)/leucovorin (lv) with fu/lv alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21:60-65, 2003
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 58
    • 21044453902 scopus 로고    scopus 로고
    • Randomized phase iii study of matrix metalloproteinase inhibitor bms-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National cancer institute of canada-clinical trials group study br.18
    • Leighl NB, Paz-Arez L, Douillard JL, et al. Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18. J Clin Oncol 23:2831-2839, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 2831-2839
    • Leighl, N.B.1    Paz-Arez, L.2    Douillard, J.L.3
  • 59
    • 33845707705 scopus 로고    scopus 로고
    • Vegf and plgf promote adult vasculogenesis by enhancing epc recruitment and vessel formation at the site of tumor neovascularization
    • Li B, Sharpe EE, Maupin AB, et al. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J 20:1495-1497, 2006
    • (2006) FASEB J , vol.20 , pp. 1495-1497
    • Li, B.1    Sharpe, E.E.2    Maupin, A.B.3
  • 60
    • 85047694353 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by pdgf-cc via effects on endothelial cells and their progenitors
    • Li X, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest 115:118-127, 2005
    • (2005) J Clin Invest , vol.115 , pp. 118-127
    • Li, X.1    Tjwa, M.2    Moons, L.3
  • 61
    • 45549096862 scopus 로고    scopus 로고
    • Peripheral lung carcinoma: Correlation of angiogenesis and first-pass perfusion parameters of 64-detector row ct
    • Li Y, Yang ZG, Chen TW, et al. Peripheral lung carcinoma: correlation of angiogenesis and first-pass perfusion parameters of 64-detector row CT. Lung Cancer 61:44-53, 2008
    • (2008) Lung Cancer , vol.61 , pp. 44-53
    • Li, Y.1    Yang, Z.G.2    Chen, T.W.3
  • 62
    • 33845321649 scopus 로고    scopus 로고
    • A phase ii study of bay 43-9006 (sorafenib) in patients with relapsed non-small cell lung cancer (nsclc
    • Liu B, Barrett T, Choyke P, et al. A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC). J Clin Oncol 24(18S):17119, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 17119
    • Liu, B.1    Barrett, T.2    Choyke, P.3
  • 63
    • 0034898468 scopus 로고    scopus 로고
    • Hmg-coa reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells
    • Llevadot J, Murasawa S, Kureish Y, et al. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. J Clin Invest 108:399-405, 2001
    • (2001) J Clin Invest , vol.108 , pp. 399-405
    • Llevadot, J.1    Murasawa, S.2    Kureish, Y.3
  • 64
    • 34249100236 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity
    • Loupakis F, Falcone A, Masi G, et al. Vascular endothelial growth factor levels in immunodepleted plasma of cancer patients as a possible pharmacodynamic marker for bevacizumab activity. J Clin Oncol 25:1816-1818, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1816-1818
    • Loupakis, F.1    Falcone, A.2    Masi, G.3
  • 65
    • 34247096543 scopus 로고    scopus 로고
    • Peripheral lung cancer: Relationship between multi-slice spiral ct perfusion imaging and tumor angiogenesis and cyclin d1 expression
    • Ma SH, Xu K, Xiao ZW, et al. Peripheral lung cancer: relationship between multi-slice spiral CT perfusion imaging and tumor angiogenesis and cyclin D1 expression. Clin Imaging 31:165-177, 2007
    • (2007) Clin Imaging , vol.31 , pp. 165-177
    • Ma, S.H.1    Xu, K.2    Xiao, Z.W.3
  • 66
    • 35548962413 scopus 로고    scopus 로고
    • Randomised, doubleblind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704
    • Manegold C, von Pawel J, Zatloukal P, et al. Randomised, doubleblind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): BO17704. J Clin Oncol 25(18S):7514, 2007
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 7514
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 67
    • 0035885932 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (vegf) is an autocrine growth factor for vegf receptor-positive human tumors
    • Masood R, Cai J, Zheng T, et al. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 98:1904-1913, 2001
    • (2001) Blood , vol.98 , pp. 1904-1913
    • Masood, R.1    Cai, J.2    Zheng, T.3
  • 68
    • 24944563475 scopus 로고    scopus 로고
    • Circulating cd34+, cd133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia
    • Massa M, Rosti V, Ramajoli I, et al. Circulating CD34+, CD133+, and vascular endothelial growth factor receptor 2-positive endothelial progenitor cells in myelofibrosis with myeloid metaplasia. J Clin Oncol 23:5688-5695, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5688-5695
    • Massa, M.1    Rosti, V.2    Ramajoli, I.3
  • 69
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumour therapy
    • Mauceri HJ, Hanna NN, Beckett MA, et al. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature 394:287-291, 1998
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.N.2    Beckett, M.A.3
  • 70
    • 34247266033 scopus 로고    scopus 로고
    • Phase ib/ii study of dmxaa combined with carboplatin and paclitaxel in non-small cell lung cancer (nsclc
    • McKeage MJ. Phase Ib/II study of DMXAA combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC). J Clin Oncol 24(18S):7102, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 7102
    • McKeage, M.J.1
  • 71
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: Chemotherapeutics as antiangiogenics
    • Miller KD, Sweeney CJ, Sledge GW Jr. Redefining the target: chemotherapeutics as antiangiogenics. J Clin Oncol 19:1195-1206, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, C.J.2    Sledge Jr., G.W.3
  • 72
    • 20244375370 scopus 로고    scopus 로고
    • Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of sdf-1, vegf, and angiopoietin-1
    • Moore MA, Hattori K, Heissig B, et al. Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1. Ann NY Acad Sci 938:36-47, 2001
    • (2001) Ann NY Acad Sci , vol.938 , pp. 36-47
    • Moore, M.A.1    Hattori, K.2    Heissig, B.3
  • 73
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-Acetic acid
    • Murata R, Siemann DW, Overgaard J, Horsman MR. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4- Acetic acid. Radiat Res 156:503-509, 2001
    • (2001) Radiat Res , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 74
    • 33750087886 scopus 로고    scopus 로고
    • Zd6474 versus gefitinib in patients with advanced nsclc: Final results from a two-part double-blind randomized phase ii trial
    • Natale RB, Bodkin D, Govindan R, et al. ZD6474 versus gefitinib in patients with advanced NSCLC: Final results from a two-part double-blind randomized phase II trial. J Clin Oncol 24(18S):7000, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 7000
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 75
    • 0038204144 scopus 로고    scopus 로고
    • Su11248 is a novel flt3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 101:3597-3605, 2003
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 76
    • 8044219670 scopus 로고    scopus 로고
    • Overexpression and activation of hepatocyte growth factor/scatter factor in human nonsmall-cell lung carcinomas
    • Olivero M, Rizzo M, Madeddu R, et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human nonsmall-cell lung carcinomas. Br J Cancer 74:1862-1868, 1996
    • (1996) Br J Cancer , vol.74 , pp. 1862-1868
    • Olivero, M.1    Rizzo, M.2    Madeddu, R.3
  • 77
    • 0034773165 scopus 로고    scopus 로고
    • E7070, a novel sulfonamide agent with potent antitumor activity in vitro and in vivo
    • Ozawa Y, Sugi NH, Nagasu T, et al. E7070, a novel sulfonamide agent with potent antitumor activity in vitro and in vivo. Eur J Cancer 37:2275-2282, 2001
    • (2001) Eur J Cancer , vol.37 , pp. 2275-2282
    • Ozawa, Y.1    Sugi, N.H.2    Nagasu, T.3
  • 79
    • 18244378841 scopus 로고    scopus 로고
    • Vascular phenotype in angiogenic and non-Angiogenic lung non-small cell carcinomas
    • Passalidou E, Trivella M, Singh N, et al. Vascular phenotype in angiogenic and non-Angiogenic lung non-small cell carcinomas. Br J Cancer 86:244-249, 2002
    • (2002) Br J Cancer , vol.86 , pp. 244-249
    • Passalidou, E.1    Trivella, M.2    Singh, N.3
  • 81
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and erbb-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523-1530, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 82
    • 0030722076 scopus 로고    scopus 로고
    • Non-small-cell lung carcinoma tumor growth without morphological evidence of neoangiogenesis
    • Pezzella F, Pastorino U, Tagliabue E, et al. Non-small-cell lung carcinoma tumor growth without morphological evidence of neoangiogenesis. Am J Pathol 151:1417-1423, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1417-1423
    • Pezzella, F.1    Pastorino, U.2    Tagliabue, E.3
  • 83
    • 1342268525 scopus 로고    scopus 로고
    • Pfister DG, Johnson DH, Azzoli CG, et al
    • Pfister DG, Johnson DH, Azzoli CG, et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol 22:330-353, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 330-353
  • 84
    • 38749083341 scopus 로고    scopus 로고
    • Increased numbers of endothelial progenitor cells in peripheral blood and tumor specimens in non-small cell lung cancer: A methodological challenge and an ongoing debate on the clinical relevance
    • Pircher A, Kähler CM, Skvortsov S, et al. Increased numbers of endothelial progenitor cells in peripheral blood and tumor specimens in non-small cell lung cancer: a methodological challenge and an ongoing debate on the clinical relevance. Oncol Rep 19:345-352, 2008
    • (2008) Oncol Rep , vol.19 , pp. 345-352
    • Pircher, A.1    Kähler, C.M.2    Skvortsov, S.3
  • 85
    • 33845771272 scopus 로고    scopus 로고
    • Imaging of angiogenesis: Clinical techniques and novel imaging methods
    • Provenzale JM. Imaging of angiogenesis: clinical techniques and novel imaging methods. AJR Am J Roentgenol 188:11-23, 2007
    • (2007) AJR Am J Roentgenol , vol.188 , pp. 11-23
    • Provenzale, J.M.1
  • 86
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 57:963-969, 1997
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    LeJeune, S.2    Scott, P.A.3
  • 87
    • 34547657584 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap in non small cell lung cancer
    • Riely GJ, Miller VA. Vascular endothelial growth factor trap in non small cell lung cancer. Clin Cancer Res 13:4623-4627, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 4623-4627
    • Riely, G.J.1    Miller, V.A.2
  • 88
    • 0037113959 scopus 로고    scopus 로고
    • Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    • Sánchez-Elsner T, Botella LM, Velasco B, et al. Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways. J Biol Chem 277:43799-43808, 2002
    • (2002) J Biol Chem , vol.277 , pp. 43799-43808
    • Sánchez-Elsner, T.1    Botella, L.M.2    Velasco, B.3
  • 89
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355:2542-2550, 2006
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 90
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ed-b domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • Santimaria M, Moscatelli G, Viale GL, et al. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin Cancer Res 9:571-579, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 571-579
    • Santimaria, M.1    Moscatelli, G.2    Viale, G.L.3
  • 91
    • 0036295515 scopus 로고    scopus 로고
    • Molecular mechanisms of ret activation in human cancer
    • Santoro M, Melillo RM, Carlomagno F, et al. Molecular mechanisms of RET activation in human cancer. Ann NY Acad Sci 963:116-121, 2002
    • (2002) Ann NY Acad Sci , vol.963 , pp. 116-121
    • Santoro, M.1    Melillo, R.M.2    Carlomagno, F.3
  • 92
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346:92-98, 2002
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 93
    • 36349033172 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib (ag-013736; ag) in patients with advanced non-small cell lung cancer (nsclc): A phase ii trial
    • Schiller JH, Larson T, Ou SI, et al. Efficacy and safety of axitinib (AG-013736; AG) in patients with advanced non-small cell lung cancer (NSCLC): A phase II trial. J Clin Oncol 25(18S):7507, 2007
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 7507
    • Schiller, J.H.1    Larson, T.2    Ou, S.I.3
  • 94
    • 20144371342 scopus 로고    scopus 로고
    • P38 mitogen-Activated protein kinase downregulates endothelial progenitor cells
    • Seeger FH, Haendeler J, Walter DH, et al. p38 mitogen-Activated protein kinase downregulates endothelial progenitor cells. Circulation 111:1184-1191, 2005
    • (2005) Circulation , vol.111 , pp. 1184-1191
    • Seeger, F.H.1    Haendeler, J.2    Walter, D.H.3
  • 95
    • 33344461837 scopus 로고    scopus 로고
    • Integrins and angiogenesis: A sticky business
    • Serini G, Valdembri D, Bussolino F. Integrins and angiogenesis: a sticky business. Exp Cell Res 312:651-658, 2006
    • (2006) Exp Cell Res , vol.312 , pp. 651-658
    • Serini, G.1    Valdembri, D.2    Bussolino, F.3
  • 96
    • 33744812156 scopus 로고    scopus 로고
    • Prognostic value of expression of vascular endothelial growth factor and its flt-1 and kdr receptors in stage i non-small-cell lung cancer
    • Seto T, Higashiyama M, Funai H, et al. Prognostic value of expression of vascular endothelial growth factor and its flt-1 and KDR receptors in stage I non-small-cell lung cancer. Lung Cancer 53:91-96, 2006
    • (2006) Lung Cancer , vol.53 , pp. 91-96
    • Seto, T.1    Higashiyama, M.2    Funai, H.3
  • 97
    • 33749005405 scopus 로고    scopus 로고
    • Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors
    • Shaked Y, Ciarrocchi A, Franco M, et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 313:1785-1787, 2006
    • (2006) Science , vol.313 , pp. 1785-1787
    • Shaked, Y.1    Ciarrocchi, A.2    Franco, M.3
  • 98
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132, 2005
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 99
    • 0037108864 scopus 로고    scopus 로고
    • Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines
    • Shiraga M, Yano S, Yamamoto A, et al. Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines. Cancer Res 62:5967-5973, 2002
    • (2002) Cancer Res , vol.62 , pp. 5967-5973
    • Shiraga, M.1    Yano, S.2    Yamamoto, A.3
  • 100
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and defi-nition of vascular-Targeted therapies
    • Siemann DW, Bibby MC, Dark GG, et al. Differentiation and defi-nition of vascular-Targeted therapies. Clin Cancer Res 11:416-420, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 101
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann DW, Mercer E, Lepler S, Rojiani AM. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int J Cancer 99:1-6, 2002
    • (2002) Int J Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 102
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-Acetic acid (dmxaa
    • Siim BG, Lee AE, Shalal-Zwain S, et al. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-Acetic acid (DMXAA). Cancer Chemother Pharmacol 51:43-52, 2003
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 43-52
    • Siim, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3
  • 103
    • 33845297206 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in previously treated, advanced non-small cell lung cancer (nsclc): Preliminary results of a multicenter phase ii trial
    • Socinski MA, Novello S, Sanchez JM, et al. Efficacy and safety of sunitinib in previously treated, advanced non-small cell lung cancer (NSCLC): Preliminary results of a multicenter phase II trial. J Clin Oncol 24(18S):7001, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 7001
    • Socinski, M.A.1    Novello, S.2    Sanchez, J.M.3
  • 104
    • 0038000632 scopus 로고    scopus 로고
    • Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation
    • Strehlow K, Werner N, Berweiler J, et al. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 107:3059-3065, 2003
    • (2003) Circulation , vol.107 , pp. 3059-3065
    • Strehlow, K.1    Werner, N.2    Berweiler, J.3
  • 105
    • 0035870297 scopus 로고    scopus 로고
    • The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
    • Sweeney CJ, Miller KD, Sissons SE, et al. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res 61:3369-3372, 2001
    • (2001) Cancer Res , vol.61 , pp. 3369-3372
    • Sweeney, C.J.1    Miller, K.D.2    Sissons, S.E.3
  • 106
    • 33846844387 scopus 로고    scopus 로고
    • A phase i dose-escalation study of zd6474 in japanese patients with solid, malignant tumors
    • Tamura T, Minami H, Yamada Y, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thoracic Oncol 1:1002-1009, 2006
    • (2006) J Thoracic Oncol , vol.1 , pp. 1002-1009
    • Tamura, T.1    Minami, H.2    Yamada, Y.3
  • 107
    • 0036896832 scopus 로고    scopus 로고
    • Expression of angiopoietins and its clinical significance in non-small cell lung cancer
    • Tanaka F, Ishikawa S, Yanagihara K, et al. Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res 62:7124-7129, 2002
    • (2002) Cancer Res , vol.62 , pp. 7124-7129
    • Tanaka, F.1    Ishikawa, S.2    Yanagihara, K.3
  • 108
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebocontrolled, multicentre study (iressa survival evaluation in lung cancer
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebocontrolled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366:1527-1537, 2005
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 110
    • 2442422177 scopus 로고    scopus 로고
    • C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: Further evidence of a mechanistic link between c-reactive protein and cardiovascular disease
    • Verma S, Kuliszewski MA, Li SH, et al. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109:2058-2067, 2004
    • (2004) Circulation , vol.109 , pp. 2058-2067
    • Verma, S.1    Kuliszewski, M.A.2    Li, S.H.3
  • 111
    • 0028046042 scopus 로고
    • The role of platelet-derived growth factor production by tumor-Associated macrophages in tumor stroma formation in lung cancer
    • Vignaud JM, Marie B, Klein N, et al. The role of platelet-derived growth factor production by tumor-Associated macrophages in tumor stroma formation in lung cancer. Cancer Res 54:5455-5463, 1994
    • (1994) Cancer Res , vol.54 , pp. 5455-5463
    • Vignaud, J.M.1    Marie, B.2    Klein, N.3
  • 112
    • 0037102369 scopus 로고    scopus 로고
    • Zd6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration. Cancer Res 62:4645-4655, 2002
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 113
    • 28144443779 scopus 로고    scopus 로고
    • Circulating endothelial cells in patients with acute myeloid leukemia
    • Wierzbowska A, Robak T, Krawczynska A, et al. Circulating endothelial cells in patients with acute myeloid leukemia. Eur J Haematol 75:492-497, 2005
    • (2005) Eur J Haematol , vol.75 , pp. 492-497
    • Wierzbowska, A.1    Robak, T.2    Krawczynska, A.3
  • 114
    • 4944249117 scopus 로고    scopus 로고
    • Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the raf/mek/erk pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter M, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64:7099-7109, 2004
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, M.2    Tang, L.3
  • 115
    • 11144354392 scopus 로고    scopus 로고
    • Direct evidence that the vegf-specific antibody bevacizumab has antivascular effects in human rectal cancer
    • Willett CG, Boucher Y, di Tomaso E, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145-147, 2004
    • (2004) Nat Med , vol.10 , pp. 145-147
    • Willett, C.G.1    Boucher, Y.2    Di Tomaso, E.3
  • 116
    • 30944452436 scopus 로고    scopus 로고
    • Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: Continued experience of a phase i trial in rectal cancer patients
    • Willett CG, Boucher Y, Duda DG, et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol 23:8136-8139, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 8136-8139
    • Willett, C.G.1    Boucher, Y.2    Duda, D.G.3
  • 117
    • 84875137516 scopus 로고    scopus 로고
    • www.oxigene.com/vascular/vascular.asp#ZYBRESTAT
  • 118
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349:427-434, 2003
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 119
    • 25144483821 scopus 로고    scopus 로고
    • Phase 1 study of abt-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies
    • Yee KW, Hagey A, Verstovsek S, et al. Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 11:6615-6624, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 6615-6624
    • Yee, K.W.1    Hagey, A.2    Verstovsek, S.3
  • 120
    • 0034655135 scopus 로고    scopus 로고
    • Synergy between angiostatin and endostatin: Inhibition of ovarian cancer growth
    • Yokoyama Y, Dhanabal M, Griffioen AW, et al. Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth. Cancer Res 60:2190-2196, 2000
    • (2000) Cancer Res , vol.60 , pp. 2190-2196
    • Yokoyama, Y.1    Dhanabal, M.2    Griffioen, A.W.3
  • 121
    • 20144388765 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells in multiple myeloma: Implications and signifi-cance
    • Zhang H, Vakil V, Braunstein M, et al. Circulating endothelial progenitor cells in multiple myeloma: implications and signifi-cance. Blood 105:3286-3294, 2005
    • (2005) Blood , vol.105 , pp. 3286-3294
    • Zhang, H.1    Vakil, V.2    Braunstein, M.3
  • 122
    • 27644440431 scopus 로고    scopus 로고
    • Expression of placenta growth factor (plgf) in non-small cell lung cancer (nsclc) and the clinical and prognostic significance
    • Zhang L, Chen J, Ke Y, et al. Expression of Placenta growth factor (PlGF) in non-small cell lung cancer (NSCLC) and the clinical and prognostic significance. World J Surg Oncol 3:68, 2005
    • (2005) World J Surg Oncol , vol.3 , pp. 68
    • Zhang, L.1    Chen, J.2    Ke, Y.3
  • 123
    • 34547817054 scopus 로고    scopus 로고
    • Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas
    • Zheng PP, Hop WC, Luider TM, et al. Increased levels of circulating endothelial progenitor cells and circulating endothelial nitric oxide synthase in patients with gliomas. Ann Neurol 62:40-48, 2007
    • (2007) Ann Neurol , vol.62 , pp. 40-48
    • Zheng, P.P.1    Hop, W.C.2    Luider, T.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.