Expression of vascular endothelial growth factor mRNA in non small-cell lung carcinomas

British Journal of Cancer

Volumn 79, Issue 2, 1999, Pages 363-369

  Fontanini, G ^a   Boldrini, L ^b   Chine S ^b   Pisaturo, F ^b   Basolo, F ^b   Calcinai, A ^b   Lucchi, M ^b   Mussi, A ^b   Angeletti, C A ^b   Bevilacqua, G ^b  

^a Division of Pathology   (Italy)

^b NONE

Author keywords

Non small cell lung cancer; Prognosis; Reverse transcription polymerase chain reaction; Vascular endothelial growth factor

Indexed keywords

DNA POLYMERASE; ISOPROTEIN; MESSENGER RNA; VASCULOTROPIN;

ADULT; AGED; ANALYTICAL EQUIPMENT; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG NON SMALL CELL CANCER; MALE; MEDIASTINUM LYMPH NODE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032944435     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690058     Document Type: Article

References (28)

1. Abu-Jawdeh GM, Faix JD, Niloff J, Tognazzi K, Manseau E, Dvorak HF and Brown LF (1996) Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab Invest 74: 1105-1115
2. American Joint Committee on Cancer (1992) Manual for a Staging of Cancer. 4th edn, Beahrs OH, Henson DE, Hutter RU, Myers MH (eds), pp. 115-122. JP Lipincott: Philadelphia PA
3. Angeletti CA, Lucchi M, Fontanini G, Mussi A, Chella A, Ribechini A, Vignati S and Bevilacqua G (1996) Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage IIIA-N2). Impact of adjuvant therapies in a subset of patients at high risk of recurrence. Cancer 78: 409-415
4. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF and Senger DR (1993) Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol 143: 1255-1262
5. Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi AJ, Dvorak HF, Senger DR, Connoly JL and Schnitt SJ (1995) Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol 26: 86-91
6. Ferrara N (1995) The role of vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Res Treatment 36: 127-137
7. Fontanini G, Bigini D, Vignati S, Basolo F, Mussi A, Lucchi M, Chinè S, Angeletti CA, Harris AL and Bevilacqua G (1995) Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 177: 57-63
8. Fontanini G, Vignati S, Boldrini L, Chinè S, Silvestri V, Lucchi M, Mussi A, Angeletti CA and Bevilacqua G (1997) Vascular endothelial growth factor (VEGF) is associated with neovascularization and influences progression of non-small cell lung carcinoma (NSCLC). Clin Cancer Res 3: 861-865
9. Harpole DH, Richards WG, Herndon JE and Sugarbaker DJ (1996) Angiogenesis and molecular biologic substaging in patients with stage I non-small cell lung cancer. Ann Thorac Surg 61: 1470-1476
10. Houck KA, Ferrara N, Winer J, Cachianes G, LI B and Leung DW (1991) The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814
11. Inoue K, Ozeki Y, Suganuma T, Sugiura Y and Tanaka S (1997) Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer 79; 206-213
12. Macchiarini P, Fontanini G, Hardin JM, Squanini F and Angeletti CA (1992) Relation of neovascularination to metastasis of non-small-cell lung cancer. Lancet 340: 45-16
13. Maeda K, Chung Y, Ogawa Y, Takatsuka S, Kang SM, Ogawa M, Sawada T and Sow M (1996) Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer 77: 858-863
14. Martiny-Baron G and Marmé D (1995) VEGF-mediated tumour angiogenesis: a new target for cancer therapy. Curr Opinion Biotechnol 6: 675-680
15. Mattern J, Koomagi R and Volm M (1995) Vascular endothelial growth factor expression and angiogenesis in non-small cell lung carcinomas. Int J Oncol 6: 1059-1062
16. Mattern J, Koomagi R and Volm M (1996) Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. Br J Cancer 73: 931-934
17. Ohta Y, Endo Y, Tanaka M, Shimizu J, Oda M, Hayashi Y, Watanabe Y and Sasaki T (1996) Significance of vascular endothelial growth factor messenger RNA expression in primary lung cancer. Clin Cancer Res 2: 1411-1416
18. Shibuya M (1995) Role of VEGF-FLT receptor system in normal and tumor angiogenesis. Adv Cancer Res 67: 281-316
19. Suzuki K. Hayashi N, Miyamoto Y, Yamamoto M, Ohkawa K, Ito Y, Sasaki Y, Yamaguchi Y, Nakase H, Noda K, Enomoto N, Arai K, Yamada Y, Yoshihara H, Tujimura T, Kawano K, Yoshikawa K and Kamada T (1996) Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res 56: 3004-3009
20. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR and Ellis LM (1995) Expression of vascular endothelial growth factor and its receptors, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55: 3964-3968
21. Takahashi Y, Cleary KR, Mai M, Kitadai Y, Bucana CD and Ellis LM (1996) Significance of vessel count and vascular endothelial growth factor and its receptors (KDR) in intestinal type gastric cancer. Clin Cancer Res 2: 1679-1684
22. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC and Abraham JA (1991) The human gene for vascular endothelial growth factor. J Biol Chem 266: 11947-11954
23. Toi M, Kondo S, Suzuki H, Yamamoto Y, Inada K, Imazawa T, Taniguchi T and Tominaga T (1996) Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77: 1101-1106
24. Volm M, Koomagi R and Mattern J (1996a) Vascular endothelial growth factor and basic fibroblast growth factor in primary lung carcinomas and the incidence of metastasis. Int J Oncol 9: 711-714
25. Volm M, Koomagi R and Mattern J (1996b) Interrelationships between microvessel density, expression of VEGF and resistance to doxorubicin of non-small lung cell carcinoma. Anticancer Res 16: 213-218
26. Wizigmann-Voos S, Breier G, Risau W and Plate KH (1995) Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res 55: 1358-1364
27. World Health Organization (1982) The World Health Organization. Histological typing of lung tumours. Am J Clin Pathol 77: 123-136
28. Yoshiji H, Gomez DE, Shibuya M and Thorgeirsson UP (1996) Expression of vascular endothelial growth factor, its receptors, and other angiogenic factors in human breast cancer. Cancer Res 56: 2013-2016