Decreased liver type I 5'-deiodinase and increased brown adipose tissue type II 5'-deiodinase activity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated Long-Evans rats

Toxicology

Volumn 114, Issue 3, 1996, Pages 199-205

  Raasmaja, Atso ^a   Viluksela, Matti ^b,c   Rozman, Karl K ^b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin (TCDD); Brown adipose tissue; Deiodinases; Liver; Thyroid hormones

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ISOENZYME; LIOTHYRONINE; THYROXINE; THYROXINE DEIODINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPOTHYROIDISM; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY WEIGHT; IODIDE PEROXIDASE; LIVER; MALE; MICROSOMES; RATS; TETRACHLORODIBENZODIOXIN; THYROXINE; TRIIODOTHYRONINE;

ANIMALIA;

EID: 0030592951     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03488-9     Document Type: Article

References (31)

1. Abrams, G.M. and Larsen, P.R. (1973) Triiodothyronine and thyroxine in the serum and thyroid glands of iodine-deficient rats. J. Clin. Invest. 52, 2522-2531.
2. Bastomsky, C.H. (1977) Enhanced thyroxine metabolism and high uptake goiters in rats after a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 101, 292-296.
3. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
4. 3 in the rat. J. Clin. Invest. 91, 2709-2713.
5. Eltom, S.A., Babish, J.G. and Ferguson, D.C. (1992) The interaction of L-triiodothyronine and 2,3,7,8,-tetrachlorodibenzo-p-dioxin on Ah-receptor-mediated hepatic phase I and phase II enzymes and iodothyronine 5-deiodinase in thyroidectomized rats. Toxicol. Lett. 61, 125-139.
6. Gorski, J.R. and Rozman, K. (1987) Dose-response and time course of hypothyroxinemia and hypoinsulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Toxicology 44, 297-307.
7. Gorski, J.R., Muzi, G., Weber, L.W.D., Pereira, D.W., Arceo, R.J., latropoulos, M.J. and Rozman, K.K. (1988a) Some endocrine and morphological aspects of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol. Pathol. 16, 313-320.
8. Gorski, J.R., Weber, L.W.D. and Rozman, K. (1988b) Tissue specific alterations of de novo fatty acid synthesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Arch. Toxicol. 62, 146-151.
9. Henry, E.C. and Gasiewicz, T.A. (1987) Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 89, 165-174.
10. Kaplan, M.M. and Utiger, R.D. (1978) Iodothyronine metabolism in liver and kidney homogenates from hyperthyroid and hypothyroid rats. Endocrinology 103, 156-161.
11. Larsen, P.R., Silva, J.E. and Larsen, P.R. (1981) Relationships between circulating intracellular thyroid hormones; physiological and clinical implications. Endocrinol. Rev. 2, 87-102.
12. Leonard, J.L., Mellen, S.A. and Larsen, P.R. (1983) Thyroxine 5-deiodinase activity in brown adipose tissue. Endocrinology 112, 1153-1155.
13. Mills, I., Raasmaja, A., Moolten, N., Lemack, G., Silva, J.E. and Larsen, P.R. (1989) Effect of thyroid status on catecholamine stimulation of thyroxine 5′-deiodinase in brown adipocytes. Am. J. Physiol. 256 (Endocrinol. Metab. 19), E74-E79.
14. Morse, D.C., Groen, D., Veerman, M., Van Amerongen, C.J. Koaeter, H.B.W.M., Van Prooije, A.E.S., Visser, T.J., Koeman, J.H. and Brewer, A. (1993) Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol. Appl. Pharmacol. 122, 27-33.
15. Pazos-Moura, C.C., Moura, E.G., Derris, M.L., Renmark, S., Melendez, L., Silva, J.E. and Taurog, A. (1991) Effect of iodine deficiency and cold exposure on thyroxine 5-deiodinase activity in various rat tissues. Am. J. Physiol. 260 (Endocrinol. Metab. 23), E175-E182.
16. Pohjanvirta, R., Unkila, M. and Tuomisto, J. (1993) Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in the most TCDD resistant rat strain. Pharmacol. Toxicol. 73, 52-56.
17. Potter, C.L., Sipes, G.L. and Haddock-Russel, D. (1983) Hypothyroxinemia and hypothermia in rats in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin administration. Toxicol. Appl. Pharmacol. 69, 89-95.
18. Potter, C.L., Moore, R.W., Inhorn, S.L., Hagen, T.C. and Peterson, R.E. (1986) Thyroid status and thermogenesis in rats treated with TCDD. Toxicol. Appl. Pharmacol. 84, 45-55.
19. Rozman, K. (1984) Hexadecane increases the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): is brown adipose tissue the primary target in TCDD-induced wasting syndrome? Biochem. Biophys. Res. Commun. 125, 996-1004.
20. Rozman, K., Rozman, T. and Greim, H. (1984) Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity. Toxicol. Appl. Pharmacol. 72, 372-376.
21. Rozman, K., Rozman, T., Scheufler, E., Pazdernik, T. and Greim, H. (1985) Thyroid hormones modulate the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J. Toxicol. Environ. Health 16, 481-491.
22. Rozman, K., Strassle, B. and Iatropoulos, M.J. (1986a) Brown adipose tissue is a target tissue in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced toxicity. Arch. Toxicol. Suppl. 9, 356-360.
23. Rozman, K., Pereira, D. and Iatropoulos, M.J. (1986b) Histopathology of interscapular brown tissue, thyroid and pancreas in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats. Toxicol. Appl. Pharmacol. 82, 551-559.
24. Silva, J.E. and Larsen, P.R. (1985) Potential of brown adipose tissue type II thyroxine 5′-deiodinase as a local and systemic source of triiodothyronine in rats. J. Clin. Invest. 76, 2296-2302.
25. Silva, J.E., Mellen, S. and Larsen, P.R. (1987) Comparison of kidney and brown adipose tissue iodothyronine 5′-deiodinases. Endocrinology 121, 650.
26. Silva, J.E., Leonard, J.L., Crantz, F.R. and Larsen, P.R. (1982) Evidence for two tissue-specific pathways for in vivo thyroxine 5′-deiodination in the rat. J. Clin. Invest. 69, 1176-1184.
27. 3 generation between euthyroid and hyothyroid rats. J. Clin. Invest. 73, 898-907.
28. Viluksela, M., Stahl, B.U. and Rozman, K.K. (1995) Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of phosphoenolpyruvate carboxykinase (PEPCK) in rats. Toxicol. Appl. Pharmacol. 135, 308-315.
29. Visser, T.J., Leonard, J.L., Kaplan, M.M. and Larsen, P.R. (1982) Kinetic evidence suggesting two mechanisms for iodothyronine 5′-deiodination in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 79, 5080-5084.
30. Visser, T.J., Kaplan, M.M., Leonard, J.L. and Larsen, P.R. (1983) Evidence for two pathways of iodothyronine 5′-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J. Clin. Invest. 71, 992.
31. Weber, L.W.D., Lebofsky, M., Stahl, B.U., Gorski, J.R., Muzi, G. and Rozman, K. (1991) Reduced activities of key enzymes of gluconeogenesis as possible cause of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Toxicology 66, 133-144.