Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)

Environment International

Volumn 29, Issue 6, 2003, Pages 855-860

  Birnbaum, Linda S ^a   Staskal, Daniele F ^b   Diliberto, Janet J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Health effect; PBDD; PBDF

Indexed keywords

BROMINE COMPOUNDS; DISEASE CONTROL; DISEASES; FLAME RETARDANTS; ORGANIC COMPOUNDS; TOXICITY;

BROMINATED FLAME RETARDANTS;

ENVIRONMENTAL ENGINEERING;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BROMINE DERIVATIVE; CYTOCHROME P450 1A1; ETHOXYRESORUFIN DEETHYLASE; FLAME RETARDANT; POLYBROMINATED DIBENZODIOXIN; POLYBROMINATED DIBENZOFURAN; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; UNSPECIFIC MONOOXYGENASE;

CHEMICAL STRUCTURE; CHLORACNE; ENVIRONMENTAL EXPOSURE; ENZYME INDUCTION; HEALTH HAZARD; HUMAN; IMMUNOTOXICITY; LETHALITY; METABOLIC DISORDER; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; TERATOGENICITY; THYMUS ATROPHY; TOXICOKINETICS; WASTING SYNDROME; WILDLIFE;

ANIMALIA;

EID: 0242319565     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/S0160-4120(03)00106-5     Document Type: Article

References (31)

1. Behnisch PA, Howoe K, Sakai S. Combinatorial/bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment. Environ Int 2001a;27:495-519.
2. Behnisch PA, Hosoe K, Sakai S. Bioanalytical screening methods for dioxins and dioxin-like compounds-a review of bioassay/biomarker technology. Environ Int 2001b;27:413-39.
3. Birnbaum LS. Evidence for the role of the Ah receptor in response to dioxin. In: Spitzer HL, Slaga TJ, Greenlee WF, McClain M, editors. Receptor-mediated biological processes: implications for evaluating carcinogenesis. Progress in Clinical and Biological Research, vol. 387. New York: Witey-Liss; 1994. p. 139-54.
4. Birnbaum LS, Morrissey RM, Harris MW. Teratogenic effects of 2,3,7,8-TBDD and three PBDFs in C57BL/6N mice. Toxicol Appl Pharmacol 1991;107:141-52.
5. Brewster DW, Birnbaum LS. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol 1987;90: 243-52.
6. Brewster DW, Birnbaum LS. Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol 1988;95:490-8.
7. Decad GM, Birnbaum LS, Matthews HB. 2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pig. Toxicol Appl Pharmacol 1981;57:231-40.
8. DeJongh J, Buser HR, Poiger H. The metabolism of 2,3,7,8-tetrabromodibenzo-p-dioxin in the rat. Xenobiotica 1993;23:19-26.
9. DeVito MJ, Ross DG, Dupuy Jr AE, Ferrario J, McDaniel D, Birnbaum LS. Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice. Toxicol Sci 1998;46:223-34.
10. 3H]tetrabromo-dibenzo-p-dioxin (TBDD) in the rat. Toxicol Appl Pharmacol 1993; 120:315-26.
11. Diliberto JJ, Burgin DE, Birnbaum LS. Effects of CYP1A2 on disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2′,4,4′,5,5′-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice. Toxicol Appl Pharmacol 1999;159:52-64.
12. Golor G, Yamashita K, McLachlan M, Hutzinger O, Neubert D. Comparison of the kinetics of clorinated and brominated dioxins and furans in the rat. In: Fiedler H, Frank H, Hutzinger O, Parzefall W, Riss A, Safe S, editors. Dioxin'93: 13th International Symposium on Chlorinated Dioxins and Related Compounds, Vienna, 20-24 September 1993. Organohalogen Compounds, vol. 12. Vienna: Austrian Federal Governmental Agency; 1993. p. 203-6.
13. Hornung MW, Zabel EW, Peterson RE. Toxic equivalency factors of polybrominated dibenzo-p-dioxin, dibenzofuran, biphenyl, and polyhalogenated diphenyl ether congeners based on rainbow trout early life stage mortality. Toxicol Appl Pharmacol 1996;140:227-34.
14. Ivens I, Loser E, Rinke M, Schmidt U, Mohr U. Toxicity of 2,3,7,8-tetrabromodibenzo-p-dioxin in rats after single oral administration. Toxicology 1993;83:181-201.
15. Jackson JA, Diliberto JJ, Birnbaum LS. Estimation of octanol-water partition coefficients and correlation with dermal absorption for several polyhalogenated aromatic hydrocarbons. Fundam Appl Toxicol 1993; 21:334-44.
16. Kedderis LB, Diliberto JJ, Birnbaum LS. Disposition and excretion of intravenous 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in rats. Toxicol Appl Pharmacol 1991a;108:397-406.
17. Kedderis LB, Diliberto JJ, Linko P, Goldstein JA, Birnbaum LS. Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2. Toxicol Appl Pharmacol 1991b;11:163-72.
18. Kedderis LB, Mills JJ, Andersen ME, Birnbaum LS. A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction. Toxicol Appl Pharmacol 1993;121:87-98.
19. Kedderis LB, Jackson JA, Patterson DG, Grainger J, Diliberto JJ, Birnbaum LS. Chemical characterization and disposition studies with 1,2,7,8-tetrabromodibenzofuran in the rat. J Toxicol Environ Health 1994;41:53-69.
20. Mason G, Zacharewski T, Denomme MA, Safe L, Safe S. Polybrominated dibenzo-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships. Toxicology 1987;44:245-55.
21. Mennear JH, Lee CC. Polybrominated dibenzo-p-dioxins and dibenzofurans: literature review and health assessment. Environ Health Perspect 1994;102(Suppl 1):265-74.
22. Moore JA, McConnell EE, Dalgard DW, Harris MW. Comparative toxicity of three halogenated dibenzofurans in guinea pigs, mice, and rhesus monkeys. Ann NY Acad Sci 1979;320:151-63.
23. Sakai S, Watanabe J, Honda Y, Takatsuki H, Aoki I, Futamatsu M, et al. Combustion of brominated flame retardants and behavior of its byproducts. Chemosphere 2001;42:519-31.
24. Santostefano MJ, Wang X, Richardson VM, Ross DG, DeVito MJ, Birnbaum LS. A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose- and time-dependent effects. Toxicol Appl Pharmacol 1998;151:294-310.
25. Schecter A, Ryan JJ. Persistent brominated and chlorinated dioxin blood levels in a chemist. 35 years after dioxin exposure. J Occup Med 1992; 34:702-7.
26. US EPA. Dioxin Reassassment. Online: http://cfpub.epa.gov/ncea/cfm/dioxreass.cfm?ActType=default; 2003.
27. Van den Berg M, Birnbaum L, Bosveld AT, Brunstrom B, Cook P, Feeley M, et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs for humans and wildlife. Environ Health Perspect 1998;106:775-9.
28. Weber LWD, Greim H. The toxicology of brominated and mixed-halogenated dibenzo-p-dioxins and dibenzofurans: an overview. J Toxicol Environ Health 1997;50:195-215.
29. World Health Organization (WHO). Polybrominated dibenzo-p-dioxins and dibenzofurans. Environ Health Criteria 1998;205 [Geneva].
30. Zhou T, Ross DG, DeVito MJ, Crofton KM. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci 2001;61:76-82.
31. Zober MA, Ott MG, Papke O, Senft K, Germann C. Morbidity study of extruder personnel with potential exposure to brominated dioxins and furans. I Results of blood monitoring and immunological tests. Br J Ind Med 1992;49:532-44.