메뉴 건너뛰기




Volumn 69, Issue 6, 2008, Pages 329-339

Integrin αvβ3-targeted cancer therapy

Author keywords

Angiogenesis; Anti angiogenic therapy; Integrin v 3; Metastasis

Indexed keywords

ABCIXIMAB; ABEGRIN; ANGIOGENESIS INHIBITOR; ARGINYLGLYCYLASPARTIC ACID; BEVACIZUMAB; CILENGITIDE; CNTO 95; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DISINTEGRIN; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; MACROGOL; MEDI 523; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY LM 609; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; OSTEOPROTEGERIN; POLYETHYLENEIMINE; S 247; SC 68448; SCH 221153; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULAR TARGETING AGENT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VITAXIN I; VITRONECTIN RECEPTOR; VITRONECTIN RECEPTOR BLOCKING AGENT;

EID: 57749090308     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20265     Document Type: Review
Times cited : (279)

References (89)
  • 2
    • 33746797624 scopus 로고    scopus 로고
    • Vascular integrins in tumor angiogenesis: Mediators and therapeutic targets
    • Alghisi GC, Raegg C. 2006. Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 13:113-135.
    • (2006) Endothelium , vol.13 , pp. 113-135
    • Alghisi, G.C.1    Raegg, C.2
  • 6
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks PC, Clark RA, Cheresh DA. 1994. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264:569-571.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 10
    • 33748616254 scopus 로고    scopus 로고
    • Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents
    • Cai W, Chen X. 2006. Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism. Anticancer Agents Med Chem 6:407-428.
    • (2006) Med Chem , vol.6 , pp. 407-428
    • Cai, W.1    Chen, X.2
  • 11
    • 0037591683 scopus 로고    scopus 로고
    • Snake venom disintegrins: Novel dimeric disintegrins and structural diversification by disulphide bond engineering
    • Calvete JJ, Moreno-Murciano MP, Theakston RDG, Kisiel DG, Marcinkiewicz C. 2003. Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem J 372:725-734.
    • (2003) Biochem J , vol.372 , pp. 725-734
    • Calvete, J.J.1    Moreno-Murciano, M.P.2    Theakston, R.D.G.3    Kisiel, D.G.4    Marcinkiewicz, C.5
  • 12
    • 42249089349 scopus 로고    scopus 로고
    • Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature
    • Cao L, Du P, Jiang S-H, Jin G-H, Huang Q-L, Hua Z-C. 2008. Enhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature. Mol Cancer Ther 7:851-858.
    • (2008) Mol Cancer Ther , vol.7 , pp. 851-858
    • Cao, L.1    Du, P.2    Jiang, S.-H.3    Jin, G.-H.4    Huang, Q.-L.5    Hua, Z.-C.6
  • 13
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. 2000. Angiogenesis in cancer and other diseases. Nature 407:249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 14
    • 0033625260 scopus 로고    scopus 로고
    • Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone
    • Carron CP, Meyer DM, Engleman VW, Rico JG, Ruminski PG, Ornberg RL, Westlin WF, Nickols GA. 2000. Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone. J Endocrinol 165:587-598.
    • (2000) J Endocrinol , vol.165 , pp. 587-598
    • Carron, C.P.1    Meyer, D.M.2    Engleman, V.W.3    Rico, J.G.4    Ruminski, P.G.5    Ornberg, R.L.6    Westlin, W.F.7    Nickols, G.A.8
  • 17
    • 0005306564 scopus 로고
    • Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
    • Cheresh DA. 1987. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc Natl Acad Sci USA 84:6471-6475.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6471-6475
    • Cheresh, D.A.1
  • 19
    • 0033646764 scopus 로고    scopus 로고
    • Potential future clinical applications for the GPIIb/IIIa antagonist, abciximab in thrombosis, vascular and oncological indications
    • Cohen SA, Trikha M, Mascelli MA. 2000. Potential future clinical applications for the GPIIb/IIIa antagonist, abciximab in thrombosis, vascular and oncological indications. Pathol Oncol Res 6:163-174.
    • (2000) Pathol Oncol Res , vol.6 , pp. 163-174
    • Cohen, S.A.1    Trikha, M.2    Mascelli, M.A.3
  • 20
    • 16244380817 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials of cilengitide, an alphav antagonist in clinical development as an anticancer agent
    • Colevas AD, Scharf O, Schoenfeldt M. 2004. Clinical trials referral resource. Current clinical trials of cilengitide, an alphav antagonist in clinical development as an anticancer agent. Oncology 18:1778-1781.
    • (2004) Oncology , vol.18 , pp. 1778-1781
    • Colevas, A.D.1    Scharf, O.2    Schoenfeldt, M.3
  • 21
    • 15544361947 scopus 로고    scopus 로고
    • Gemcitabine and paclitaxel in metastatic breast cancer: A review
    • Colomer R. 2004. Gemcitabine and paclitaxel in metastatic breast cancer: a review. Oncology 18(Suppl 12):8-12.
    • (2004) Oncology , vol.18 , Issue.SUPPL. 12 , pp. 8-12
    • Colomer, R.1
  • 22
    • 14944353793 scopus 로고    scopus 로고
    • Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs
    • Corti A, Ponzoni M. 2004. Tumor vascular targeting with tumor necrosis factor alpha and chemotherapeutic drugs. Ann NY Acad Sci 1028:104-112.
    • (2004) Ann NY Acad Sci , vol.1028 , pp. 104-112
    • Corti, A.1    Ponzoni, M.2
  • 23
    • 38149098569 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors
    • Delbaldo C, Raymond E, Vera K, Hammershaimb L, Kaucic K, Lozahic S, Marty M, Faivre S. 2008. Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs 26:35-43.
    • (2008) Invest New Drugs , vol.26 , pp. 35-43
    • Delbaldo, C.1    Raymond, E.2    Vera, K.3    Hammershaimb, L.4    Kaucic, K.5    Lozahic, S.6    Marty, M.7    Faivre, S.8
  • 25
    • 42249084453 scopus 로고    scopus 로고
    • Pharmacology of the novel antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a u-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth
    • Donate F, Parry GC, Shaked Y, Hensley H, Guan X, Beck I, Tel-Tsur Z, Plunkett ML, Manuia M, Shaw DE, Kerbel RS, Mazar AP. 2008. Pharmacology of the novel antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): observation of a u-shaped dose-response curve in several preclinical models of angiogenesis and tumor growth. Clin Cancer Res 14:2137-2144.
    • (2008) Clin Cancer Res , vol.14 , pp. 2137-2144
    • Donate, F.1    Parry, G.C.2    Shaked, Y.3    Hensley, H.4    Guan, X.5    Beck, I.6    Tel-Tsur, Z.7    Plunkett, M.L.8    Manuia, M.9    Shaw, D.E.10    Kerbel, R.S.11    Mazar, A.P.12
  • 27
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. 1971. Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 28
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. 1995a. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med 1:27-31.
    • (1995) Nature Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 29
    • 84975525035 scopus 로고
    • Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • Folkman J. 1995b. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med 333:1757-1763.
    • (1995) N Engl J Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 30
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. 2002. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29(Suppl 16):15-18.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 16 , pp. 15-18
    • Folkman, J.1
  • 32
    • 33845197894 scopus 로고    scopus 로고
    • The application of siRNA technology to cancer biology discovery
    • Fuchs U, Borkhardt A. 2007. The application of siRNA technology to cancer biology discovery. Adv Cancer Res 96:75-102.
    • (2007) Adv Cancer Res , vol.96 , pp. 75-102
    • Fuchs, U.1    Borkhardt, A.2
  • 33
    • 0024206252 scopus 로고
    • Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus
    • Gan ZR, Gould RJ, Jacobs JW, Friedman PA, Polokoff MA. 1988. Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus. J Biol Chem 263:19827-19832.
    • (1988) J Biol Chem , vol.263 , pp. 19827-19832
    • Gan, Z.R.1    Gould, R.J.2    Jacobs, J.W.3    Friedman, P.A.4    Polokoff, M.A.5
  • 34
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W, Giancotti FG. 2004. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5:816-826.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 40
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • Hood JD, Cheresh DA. 2002. Role of integrins in cell invasion and migration. Nat Rev Cancer 2:91-100.
    • (2002) Nat Rev Cancer , vol.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 42
    • 0031814234 scopus 로고    scopus 로고
    • What have snakes taught us about integrins?
    • Huang TF. 1998. What have snakes taught us about integrins? Cell Mol Life Sci 54:527-540.
    • (1998) Cell Mol Life Sci , vol.54 , pp. 527-540
    • Huang, T.F.1
  • 43
    • 0023639428 scopus 로고
    • Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex
    • Huang TF, Holt JC, Lukasiewicz H, Niewiarowski S. 1987. Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. J Biol Chem 262:16157-16163.
    • (1987) J Biol Chem , vol.262 , pp. 16157-16163
    • Huang, T.F.1    Holt, J.C.2    Lukasiewicz, H.3    Niewiarowski, S.4
  • 44
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673-687.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 45
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. 2001. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 46
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. 2005. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 48
    • 1542269303 scopus 로고    scopus 로고
    • Integrins: Roles in cancer development and as treatment targets
    • Jin H, Varner J. 2004. Integrins: roles in cancer development and as treatment targets. Br J Cancer 90:561-565.
    • (2004) Br J Cancer , vol.90 , pp. 561-565
    • Jin, H.1    Varner, J.2
  • 49
    • 0037318003 scopus 로고    scopus 로고
    • Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis
    • Kumar CC. 2003. Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr Drug Targets 4:123-131.
    • (2003) Curr Drug Targets , vol.4 , pp. 123-131
    • Kumar, C.C.1
  • 51
    • 0142061975 scopus 로고    scopus 로고
    • Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells
    • Lipscomb EA, Dugan AS, Rabinovitz I, Mercurio AM. 2003. Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis 20:569-576.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 569-576
    • Lipscomb, E.A.1    Dugan, A.S.2    Rabinovitz, I.3    Mercurio, A.M.4
  • 52
    • 84934439937 scopus 로고    scopus 로고
    • Delivering small interfering RNA for novel therapeutics
    • Lu PY, Woodle MC. 2008. Delivering small interfering RNA for novel therapeutics. Methods Mol Biol 437:93-107.
    • (2008) Methods Mol Biol , vol.437 , pp. 93-107
    • Lu, P.Y.1    Woodle, M.C.2
  • 57
    • 33646794420 scopus 로고    scopus 로고
    • Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent
    • Minea R, Swenson S, Costa F, Chen TC, Markland FS. 2005. Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent. Pathophysiol Haemost Thromb 34:177-183.
    • (2005) Pathophysiol Haemost Thromb , vol.34 , pp. 177-183
    • Minea, R.1    Swenson, S.2    Costa, F.3    Chen, T.C.4    Markland, F.S.5
  • 62
    • 0842333243 scopus 로고    scopus 로고
    • alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
    • Nisato RE, Tille J-C, Jonczyk A, Goodman SL, Pepper MS. 2003. alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 6:105-119.
    • (2003) Angiogenesis , vol.6 , pp. 105-119
    • Nisato, R.E.1    Tille, J.-C.2    Jonczyk, A.3    Goodman, S.L.4    Pepper, M.S.5
  • 64
    • 0035706407 scopus 로고    scopus 로고
    • A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer
    • Posey JA, Khazaeli MB, DelGrosso A, Saleh MN, Lin CY, Huse W, LoBuglio AF. 2001. A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer. Cancer Biother Radiopharm 16:125-132.
    • (2001) Cancer Biother Radiopharm , vol.16 , pp. 125-132
    • Posey, J.A.1    Khazaeli, M.B.2    DelGrosso, A.3    Saleh, M.N.4    Lin, C.Y.5    Huse, W.6    LoBuglio, A.F.7
  • 65
    • 0036884547 scopus 로고    scopus 로고
    • vbeta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody
    • vbeta3 targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody. FASEB J 16:2000-2002.
    • (2002) FASEB J , vol.16 , pp. 2000-2002
    • Rader, C.1    Popkov, M.2    Neves, J.A.3    Barbas, C.F.4
  • 66
    • 0346158521 scopus 로고    scopus 로고
    • Cilengitide (EMD 12, 1974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour
    • Raguse J-D, Gath HJ, Bier J, Riess H, Oettle H. 2004. Cilengitide (EMD 12, 1974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour. Oral Oncol 40:228-230.
    • (2004) Oral Oncol , vol.40 , pp. 228-230
    • Raguse, J.-D.1    Gath, H.J.2    Bier, J.3    Riess, H.4    Oettle, H.5
  • 67
    • 0023058313 scopus 로고
    • Arg-Gly-Asp: A versatile cell recognition signal
    • Ruoslahti E, Pierschbacher MD. 1986. Arg-Gly-Asp: a versatile cell recognition signal. Cell 44:517-518.
    • (1986) Cell , vol.44 , pp. 517-518
    • Ruoslahti, E.1    Pierschbacher, M.D.2
  • 68
    • 4944230230 scopus 로고    scopus 로고
    • Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor alpha (NGR-TNF) and doxorubicin
    • Sacchi A, Gasparri A, Curnis F, Bellone M, Corti A. 2004. Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor alpha (NGR-TNF) and doxorubicin. Cancer Res 64:7150-7155.
    • (2004) Cancer Res , vol.64 , pp. 7150-7155
    • Sacchi, A.1    Gasparri, A.2    Curnis, F.3    Bellone, M.4    Corti, A.5
  • 71
    • 0035575458 scopus 로고    scopus 로고
    • Integrin signaling revisited
    • Schwartz MA. 2001. Integrin signaling revisited. Trends Cell Biol 11:466-470.
    • (2001) Trends Cell Biol , vol.11 , pp. 466-470
    • Schwartz, M.A.1
  • 73
    • 0024852988 scopus 로고
    • Characterization and platelet inhibitory activity of bitistatin, a potent arginine-glycine- aspartic acid-containing peptide from the venom of the viper Bitis arietans
    • Shebuski RJ, Ramjit DR, Bencen GH, Polokoff MA. 1989. Characterization and platelet inhibitory activity of bitistatin, a potent arginine-glycine- aspartic acid-containing peptide from the venom of the viper Bitis arietans. J Biol Chem 264:21550-21556.
    • (1989) J Biol Chem , vol.264 , pp. 21550-21556
    • Shebuski, R.J.1    Ramjit, D.R.2    Bencen, G.H.3    Polokoff, M.A.4
  • 75
    • 33745198717 scopus 로고    scopus 로고
    • Antiangiogenic combination tumor therapy blocking alphav-integrins and VEGF-receptor-2 increases therapeutic effects in vivo
    • Strieth S, Eichhorn ME, Sutter A, Jonczyk A, Berghaus A, Dellian M. 2006. Antiangiogenic combination tumor therapy blocking alphav-integrins and VEGF-receptor-2 increases therapeutic effects in vivo. Int J Cancer 119:423-431.
    • (2006) Int J Cancer , vol.119 , pp. 423-431
    • Strieth, S.1    Eichhorn, M.E.2    Sutter, A.3    Jonczyk, A.4    Berghaus, A.5    Dellian, M.6
  • 76
  • 79
    • 2442488748 scopus 로고    scopus 로고
    • CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo
    • Trikha M, Zhou Z, Nemeth JA, Chen Q, Sharp C, Emmell E, Giles-Komar J, Nakada MT. 2004. CNTO 95, a fully human monoclonal antibody that inhibits alphav integrins, has antitumor and antiangiogenic activity in vivo. Int J Cancer 110:326-335.
    • (2004) Int J Cancer , vol.110 , pp. 326-335
    • Trikha, M.1    Zhou, Z.2    Nemeth, J.A.3    Chen, Q.4    Sharp, C.5    Emmell, E.6    Giles-Komar, J.7    Nakada, M.T.8
  • 80
    • 0037092984 scopus 로고    scopus 로고
    • Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis
    • Trikha M, Zhou Z, Timar J, Raso E, Kennel M, Emmell E, Nakada MT. 2002. Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis. Cancer Res 62:2824-2833.
    • (2002) Cancer Res , vol.62 , pp. 2824-2833
    • Trikha, M.1    Zhou, Z.2    Timar, J.3    Raso, E.4    Kennel, M.5    Emmell, E.6    Nakada, M.T.7
  • 81
    • 0035724579 scopus 로고    scopus 로고
    • Function and interactions of integrins
    • Van der Flier A, Sonnenberg A. 2001. Function and interactions of integrins. Cell Tissue Res 305:285-298.
    • (2001) Cell Tissue Res , vol.305 , pp. 285-298
    • Van der Flier, A.1    Sonnenberg, A.2
  • 83
    • 0002588527 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro)
    • Varner JA, Nakada MT, Jordan RE, Coller BS. 1999. Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro). Angiogenesis 3:53-60.
    • (1999) Angiogenesis , vol.3 , pp. 53-60
    • Varner, J.A.1    Nakada, M.T.2    Jordan, R.E.3    Coller, B.S.4
  • 85
    • 49849103664 scopus 로고    scopus 로고
    • Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein
    • Wang H, Chen K, Cai W, Li Z, He L, Kashefi A, Chen X. 2008. Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein. Mol Cancer Ther 7:1044-1053.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1044-1053
    • Wang, H.1    Chen, K.2    Cai, W.3    Li, Z.4    He, L.5    Kashefi, A.6    Chen, X.7
  • 86
    • 0036839554 scopus 로고    scopus 로고
    • Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases
    • Wilder RL. 2002. Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis 61(Suppl 2):96-99.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2 , pp. 96-99
    • Wilder, R.L.1
  • 88
    • 1842787584 scopus 로고    scopus 로고
    • Inhibition of tumor growth by intramuscular injection of cDNA encoding tumor necrosis factor alpha coupled to NGR and RGD tumor-homing peptides
    • Zarovni N, Monaco L, Corti A. 2004. Inhibition of tumor growth by intramuscular injection of cDNA encoding tumor necrosis factor alpha coupled to NGR and RGD tumor-homing peptides. Hum Gene Ther 15:373-382.
    • (2004) Hum Gene Ther , vol.15 , pp. 373-382
    • Zarovni, N.1    Monaco, L.2    Corti, A.3
  • 89
    • 1242292339 scopus 로고    scopus 로고
    • Purification, cloning and biological characterization of a novel disintegrin from Trimeresurus jerdonii venom
    • Zhou X-D, Jin Y, Chen R-Q, Lu Q-M, Wu J-B, Wang W-Y, Xiong Y-L. 2004. Purification, cloning and biological characterization of a novel disintegrin from Trimeresurus jerdonii venom. Toxicon 43:69-75.
    • (2004) Toxicon , vol.43 , pp. 69-75
    • Zhou, X.-D.1    Jin, Y.2    Chen, R.-Q.3    Lu, Q.-M.4    Wu, J.-B.5    Wang, W.-Y.6    Xiong, Y.-L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.