CNTO 95, a fully human anti αv integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells

Clinical and Experimental Metastasis

Volumn 25, Issue 2, 2008, Pages 139-148

  Chen, Qiming ^a   Manning, Carol D ^a   Millar, Hillary ^a   McCabe, Francis L ^a   Ferrante, Catherine ^a   Sharp, Celia ^a   Shahied Arruda, Lillian ^a   Doshi, Parul ^a   Nakada, Marian T ^a   Anderson, G Mark ^a  

^a CENTOCOR INC   (United States)

Author keywords

v integrin; Breast cancer; Cell invasion; Cell migration; CNTO 95; Focal adhesion kinase; Lung metastasis; MCF 7; MDA MB 231; MDA MB 468; MX 1; Paxillin

Indexed keywords

CD51 ANTIGEN; FOCAL ADHESION KINASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2077Z; MONOCLONAL ANTIBODY CNTO 95; MONOCLONAL ANTIBODY F105; MONOCLONAL ANTIBODY LM609; MONOCLONAL ANTIBODY P1F6; PAXILLIN; TYROSINE; UNCLASSIFIED DRUG; VITRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER INVASION; CANCER MODEL; CANCER TRANSPLANTATION; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG DOSE COMPARISON; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; FOCAL ADHESION KINASE 1; HUMANS; INTEGRIN ALPHAV; LUNG NEOPLASMS; MICE; MICE, SCID; NEOPLASM INVASIVENESS; PAXILLIN; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; VITRONECTIN;

EID: 41149113577     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10585-007-9132-4     Document Type: Article

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