CD8+ regulatory T cells in persistent human viral infections

Human Immunology

Volumn 69, Issue 11, 2008, Pages 771-775

  Billerbeck, Eva ^a   Thimme, Robert ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

CD8+ regulatory T cells; HCV; HIV; Immune suppression; Viral infection

Indexed keywords

CYTOKINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL HETEROGENEITY; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; HEPATITIS C; HEPATITIS C VIRUS; HERPES; HERPES VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; NONHUMAN; PERSISTENT VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; IMMUNE TOLERANCE; T-LYMPHOCYTE SUBSETS; VIRUS DISEASES; VIRUSES;

EID: 57649102577     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.07.016     Document Type: Article

References (60)

1. Shoukry N.H., Cawthon A.G., and Walker C.M. Cell-mediated immunity and the outcome of hepatitis C virus infection. Annu Rev Microbiol 58 (2004) 391-424
2. Klenerman P., and Hill A. T cells and viral persistence: Lessons from diverse infections. Nat Immunol 6 (2005) 873-879
3. McMichael A.J., and Rowland-Jones S.L. Cellular immune responses to HIV. Nature 410 (2001) 980-987
4. Shoukry N.H., Grakoui A., Houghton M., Chien D.Y., Ghrayeb J., Reimann K.A., et al. Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection. J Exp Med 197 (2003) 1645-1655
5. Thimme R., Oldach D., Chang K.M., Steiger C., Ray S.C., and Chisari F.V. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194 (2001) 1395-1406
6. Schmitz J.E., Kuroda M.J., Santra S., Sasseville V.G., Simon M.A., Lifton M.A., et al. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283 (1999) 857-860
7. Trautmann L., Janbazian L., Chomont N., Said E.A., Gimmig S., Bessette B., et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 12 (2006) 1198-1202
8. Barber D.L., Wherry E.J., Masopust D., Zhu B., Allison J.P., Sharpe A.H., et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439 (2006) 682-687
9. Day C.L., Kaufmann D.E., Kiepiela P., Brown J.A., Moodley E.S., Reddy S., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443 (2006) 350-354
10. Brooks D.G., Trifilo M.J., Edelmann K.H., Teyton L., McGavern D.B., and Oldstone M.B. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12 (2006) 1301-1309
11. Ejrnaes M., Filippi C.M., Martinic M.M., Ling E.M., Togher L.M., Crotty S., et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med 203 (2006) 2461-2472
12. Li S., Gowans E.J., Chougnet C., Plebanski M., and Dittmer U. Natural regulatory T cells and persistent viral infection. J Virol 82 (2008) 21-30
13. Belkaid Y. Regulatory T cells and infection: A dangerous necessity. Nat Rev Immunol 7 (2007) 875-888
14. Belkaid Y., and Rouse B.T. Natural regulatory T cells in infectious disease. Nat Immunol 6 (2005) 353-360
15. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6 (2005) 345-352
16. Tang Q., and Bluestone J.A. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation. Nat Immunol 9 (2008) 239-244
17. Shevach E.M. From vanilla to 28 flavors: Multiple varieties of T regulatory cells. Immunity 25 (2006) 195-201
18. Bluestone J.A., and Abbas A.K. Natural versus adaptive regulatory T cells. Nat Rev Immunol 3 (2003) 253-257
19. Campbell D.J., and Ziegler S.F. FOXP3 modifies the phenotypic and functional properties of regulatory T cells. Nat Rev Immunol 7 (2007) 305-310
20. Ziegler S.F. FOXP3: Not just for regulatory T cells anymore. Eur J Immunol 37 (2007) 21-23
21. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol 6 (2005) 338-344
22. Sojka D.K., Huang Y.H., and Fowell D.J. Mechanisms of regulatory T-cell suppression-a diverse arsenal for a moving target. Immunology 124 (2008) 13-22
23. Green D.R., Flood P.M., and Gershon R.K. Immunoregulatory T-cell pathways. Annu Rev Immunol 1 (1983) 439-463
24. Reinherz E.L., and Schlossman S.F. The differentiation and function of human T lymphocytes. Cell 19 (1980) 821-827
25. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., and Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155 (1995) 1151-1164
26. Jiang H., and Chess L. An integrated view of suppressor T cell subsets in immunoregulation. J Clin Invest 114 (2004) 1198-1208
27. Cosmi L., Liotta F., Lazzeri E., Francalanci M., Angeli R., Mazzinghi B., et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 102 (2003) 4107-4114
28. Jiang H., and Chess L. The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1. Annu Rev Immunol 18 (2000) 185-216
29. Sarantopoulos S., Lu L., and Cantor H. Qa-1 restriction of CD8+ suppressor T cells. J Clin Invest 114 (2004) 1218-1221
30. Hu D., Ikizawa K., Lu L., Sanchirico M.E., Shinohara M.L., and Cantor H. Analysis of regulatory CD8 T cells in Qa-1-deficient mice. Nat Immunol 5 (2004) 516-523
31. Li J., Goldstein I., Glickman-Nir E., Jiang H., and Chess L. Induction of TCR Vbeta-specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E. J Immunol 167 (2001) 3800-3808
32. Tennakoon D.K., Mehta R.S., Ortega S.B., Bhoj V., Racke M.K., and Karandikar N.J. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. J Immunol 176 (2006) 7119-7129
33. James E.A., and Kwok W.W. CD8+ suppressor-mediated regulation of human CD4+ T cell responses to glutamic acid decarboxylase 65. Eur J Immunol 37 (2007) 78-86
34. Bisikirska B., Colgan J., Luban J., Bluestone J.A., and Herold K.C. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest 115 (2005) 2904-2913
35. Jarvis L.B., Matyszak M.K., Duggleby R.C., Goodall J.C., Hall F.C., and Gaston J.S. Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function. Eur J Immunol 35 (2005) 2896-2908
36. Mahic M., Henjum K., Yaqub S., Bjornbeth B.A., Torgersen K.M., Tasken K., et al. Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation. Eur J Immunol 38 (2008) 640-646
37. Joosten S.A., van Meijgaarden K.E., Savage N.D., de Boer T., Triebel F., van der Wal A., et al. Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci U S A 104 (2007) 8029-8034
38. Letvin N.L., and Walker B.D. HIV versus the immune system: Another apparent victory for the virus. J Clin Invest 107 (2001) 273-275
39. Walker B.D., and Burton D.R. Toward an AIDS vaccine. Science 320 (2008) 760-764
40. Garba M.L., Pilcher C.D., Bingham A.L., Eron J., and Frelinger J.A. HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells. J Immunol 168 (2002) 2247-2254
41. Elrefaei M., Barugahare B., Ssali F., Mugyenyi P., and Cao H. HIV-specific IL-10-positive CD8+ T cells are increased in advanced disease and are associated with decreased HIV-specific cytolysis. J Immunol 176 (2006) 1274-1280
42. Elrefaei M., Ventura F.L., Baker C.A., Clark R., Bangsberg D.R., and Cao H. HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells. J Immunol 178 (2007) 3265-3271
43. Elrefaei M., Baker C.A., Jones N.G., Bangsberg D.R., and Cao H. Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells. J Immunol 180 (2008) 7757-7763
44. Freeman G.J., Wherry E.J., Ahmed R., and Sharpe A.H. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med 203 (2006) 2223-2227
45. Kornfeld C., Ploquin M.J., Pandrea I., Faye A., Onanga R., Apetrei C., et al. Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 115 (2005) 1082-1091
46. Karlsson I., Malleret B., Brochard P., Delache B., Calvo J., Le Grand R., et al. FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. J Virol 81 (2007) 13444-13455
47. Lauer G.M., and Walker B.D. Hepatitis C virus infection. N Engl J Med 345 (2001) 41-52
48. Dustin L.B., and Rice C.M. Flying under the radar: The immunobiology of hepatitis C. Annu Rev Immunol 25 (2007) 71-99
49. Bowen D.G., and Walker C.M. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 436 (2005) 946-952
50. Dolganiuc A., and Szabo G. T cells with regulatory activity in hepatitis C virus infection: What we know and what we don't. J Leukoc Biol (2008) May 21, [E-pub ahead of print]
51. Alatrakchi N., Graham C.S., Van der Vliet J., Sherman K.E., Exley M.A., and Koziel M.J. Hepatitis C virus (HCV) specific CD8+ cells produce TGF-beta that can suppress HCV-specific T cell responses. J Virol 81 (2007) 5882-5892
52. Billerbeck E., Blum H.E., and Thimme R. Parallel expansion of human virus-specific FoxP3- effector memory and de novo-generated FoxP3+ regulatory CD8+ T cells upon antigen recognition in vitro. J Immunol 179 (2007) 1039-1048
53. Accapezzato D., Francavilla V., Paroli M., Casciaro M., Chircu L.V., Cividini A., et al. Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection. J Clin Invest 113 (2004) 963-972
54. Abel M., Sene D., Pol S., Bourliere M., Poynard T., Charlotte F., et al. Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology 44 (2006) 1607-1616
55. Koelle D.M., and Corey L. Herpes simplex: Insights on pathogenesis and possible vaccines. Annu Rev Med 59 (2008) 381-395
56. Hislop A.D., Taylor G.S., Sauce D., and Rickinson A.B. Cellular responses to viral infection in humans: Lessons from Epstein-Barr virus. Annu Rev Immunol 25 (2007) 587-617
57. Suvas S., Kumaraguru U., Pack C.D., Lee S., and Rouse B.T. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 198 (2003) 889-901
58. Suvas S., Azkur A.K., Kim B.S., Kumaraguru U., and Rouse B.T. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 172 (2004) 4123-4132
59. Nordstrom I., Nurkkala M., Collins L.V., and Eriksson K. CD8+ T-cells suppress antigen-specific and allogeneic CD4+ T-cell responses to herpes simplex virus type 2-infected human dendritic cells. Viral Immunol 18 (2005) 616-626
60. Popescu I., Macedo C., Abu-Elmagd K., Shapiro R., Hua Y., Thomson A.W., et al. EBV-specific CD8+ T cell reactivation in transplant patients results in expansion of CD8+ type-1 regulatory T cells. Am J Transplant 7 (2007) 1215-1223