-
1
-
-
1542315585
-
Structure and function of choline kinase isoforms in mammalian cells
-
Aoyama, C.; Liao, H.; Ishidate, K. Structure and function of choline kinase isoforms in mammalian cells. Prog. Lipid Res. 2004, 43, 266-281.
-
(2004)
Prog. Lipid Res
, vol.43
, pp. 266-281
-
-
Aoyama, C.1
Liao, H.2
Ishidate, K.3
-
2
-
-
0027383940
-
Phosphorylcholine: A novel second messenger essential for mitogenic activity of growth factors
-
Cuadrado, A.; Carnero, A.; Dolfi, F.; Jimenez, B.; Lacal, J. C. Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene 1993, 8, 2959-2968.
-
(1993)
Oncogene
, vol.8
, pp. 2959-2968
-
-
Cuadrado, A.1
Carnero, A.2
Dolfi, F.3
Jimenez, B.4
Lacal, J.C.5
-
3
-
-
4644284916
-
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression
-
Ramirez de Molina, A.; Banez-Coronel, M.; Gutierrez, R.; Rodriguez-Gonzalez, A.; Olmeda, D.; Megias, D.; Lacal, J. C. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res. 2004, 64, 6732-6739.
-
(2004)
Cancer Res
, vol.64
, pp. 6732-6739
-
-
Ramirez de Molina, A.1
Banez-Coronel, M.2
Gutierrez, R.3
Rodriguez-Gonzalez, A.4
Olmeda, D.5
Megias, D.6
Lacal, J.C.7
-
4
-
-
0028918256
-
Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation
-
Jimenez, B.; del Peso, L.; Montaner, S.; Esteve, P.; Lacal, J. C. Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. J. Cell. Biochem. 1995, 57, 141-149.
-
(1995)
J. Cell. Biochem
, vol.57
, pp. 141-149
-
-
Jimenez, B.1
del Peso, L.2
Montaner, S.3
Esteve, P.4
Lacal, J.C.5
-
5
-
-
4644270297
-
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
-
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Fernandez, F.; Lacal, J. C. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene 2004, 23, 8247-8259.
-
(2004)
Oncogene
, vol.23
, pp. 8247-8259
-
-
Rodriguez-Gonzalez, A.1
Ramirez de Molina, A.2
Fernandez, F.3
Lacal, J.C.4
-
6
-
-
0030681263
-
Choline kinase inhibitors as a novel approach for antiproliferative drug design
-
Hernandez-Alcoceba, R.; Saniger, L.; Campos, J.; Nunez, M. C.; Khaless, F.; Gallo, M. A.; Espinosa, A.; Lacal, J. C. Choline kinase inhibitors as a novel approach for antiproliferative drug design. Oncogene 1997, 15, 2289-2301.
-
(1997)
Oncogene
, vol.15
, pp. 2289-2301
-
-
Hernandez-Alcoceba, R.1
Saniger, L.2
Campos, J.3
Nunez, M.C.4
Khaless, F.5
Gallo, M.A.6
Espinosa, A.7
Lacal, J.C.8
-
7
-
-
0036385709
-
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
-
Ramirez de Molina, A.; Rodriguez-Gonzalez, A.; Gutierrez, R.; Martinez-Pineiro, L.; Sanchez, J.; Bonilla, F.; Rosell, R.; Lacal, J. C. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem. Biophys. Res. Commun. 2002, 296, 580-583.
-
(2002)
Biochem. Biophys. Res. Commun
, vol.296
, pp. 580-583
-
-
Ramirez de Molina, A.1
Rodriguez-Gonzalez, A.2
Gutierrez, R.3
Martinez-Pineiro, L.4
Sanchez, J.5
Bonilla, F.6
Rosell, R.7
Lacal, J.C.8
-
8
-
-
33947127063
-
Phosphocholine as a biomarker of breast cancer: Molecular and biochemical studies
-
Eliyahu, G.; Kreizman, T.; Degani, H. Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies. Int. J. Cancer 2007, 120, 1721-1730.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1721-1730
-
-
Eliyahu, G.1
Kreizman, T.2
Degani, H.3
-
9
-
-
0032951381
-
Increased choline kinase activity and elevated phosphocholine levels in human colon cancer
-
Nakagami, K.; Uchida, T.; Ohwada, S.; Koibuchi, Y.; Suda, Y.; Sekine, T.; Morishita, Y. Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. Jpn. J. Cancer Res. 1999, 90, 419-424.
-
(1999)
Jpn. J. Cancer Res
, vol.90
, pp. 419-424
-
-
Nakagami, K.1
Uchida, T.2
Ohwada, S.3
Koibuchi, Y.4
Suda, Y.5
Sekine, T.6
Morishita, Y.7
-
10
-
-
0037142610
-
Increased choline kinase activity in human breast carcinomas: Clinical evidence for a potential novel antitumor strategy
-
Ramirez de Molina, A.; Gutierrez, R.; Ramos, M. A.; Silva, J. M.; Silva, J.; Bonilla, F.; Sanchez, J. J.; Lacal, J. C. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 2002, 21, 4317-4322.
-
(2002)
Oncogene
, vol.21
, pp. 4317-4322
-
-
Ramirez de Molina, A.1
Gutierrez, R.2
Ramos, M.A.3
Silva, J.M.4
Silva, J.5
Bonilla, F.6
Sanchez, J.J.7
Lacal, J.C.8
-
11
-
-
34748827371
-
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: A retrospective study
-
Ramirez de Molina, A.; Sarmentero-Estrada, J.; Belda-Iniesta, C.; Taron, M.; Ramirez de Molina, V.; Cejas, P.; Skrzypski, M.; Gallego-Ortega, D.; de Castro, J.; Casado, E.; Garcia-Cabezas, M. A.; Sanchez, J. J.; Nistal, M.; Rosell, R.; Gonzalez-Baron, M.; Lacal, J. C. Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol. 2007, 8, 889-897.
-
(2007)
Lancet Oncol
, vol.8
, pp. 889-897
-
-
Ramirez de Molina, A.1
Sarmentero-Estrada, J.2
Belda-Iniesta, C.3
Taron, M.4
Ramirez de Molina, V.5
Cejas, P.6
Skrzypski, M.7
Gallego-Ortega, D.8
de Castro, J.9
Casado, E.10
Garcia-Cabezas, M.A.11
Sanchez, J.J.12
Nistal, M.13
Rosell, R.14
Gonzalez-Baron, M.15
Lacal, J.C.16
-
12
-
-
34247103325
-
Methyl-3H]-choline incorporation into MCF-7 cells: Correlation with proliferation, choline kinase and phospholipase D assay
-
Al-Saeedi, F.; Smith, T.; Welch, A. [Methyl-3H]-choline incorporation into MCF-7 cells: correlation with proliferation, choline kinase and phospholipase D assay. Anticancer Res. 2007, 27, 901-906.
-
(2007)
Anticancer Res
, vol.27
, pp. 901-906
-
-
Al-Saeedi, F.1
Smith, T.2
Welch, A.3
-
13
-
-
21344469461
-
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis
-
Ramirez de Molina, A.; Gallego-Ortega, D.; Sarmentero, J.; Banez-Coronel, M.; Martin-Cantalejo, Y.; Lacal, J. C. Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis. Cancer Res. 2005, 65, 5647-5653.
-
(2005)
Cancer Res
, vol.65
, pp. 5647-5653
-
-
Ramirez de Molina, A.1
Gallego-Ortega, D.2
Sarmentero, J.3
Banez-Coronel, M.4
Martin-Cantalejo, Y.5
Lacal, J.C.6
-
14
-
-
37049027725
-
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells
-
Mori, N.; Glunde, K.; Takagi, T.; Raman, V.; Bhujwalla, Z. M. Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells. Cancer Res. 2007, 67, 11284-11290.
-
(2007)
Cancer Res
, vol.67
, pp. 11284-11290
-
-
Mori, N.1
Glunde, K.2
Takagi, T.3
Raman, V.4
Bhujwalla, Z.M.5
-
15
-
-
0038089964
-
In vivo anti-tumor activity of choline kinase inhibitors: A novel target for anti-cancer drug discovery
-
Hernandez-Alcoceba, R.; Fernandez, F.; Lacal, J. C. In vivo anti-tumor activity of choline kinase inhibitors: a novel target for anti-cancer drug discovery. Cancer Res. 1999, 59, 3112-3118.
-
(1999)
Cancer Res
, vol.59
, pp. 3112-3118
-
-
Hernandez-Alcoceba, R.1
Fernandez, F.2
Lacal, J.C.3
-
16
-
-
21344448680
-
Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism
-
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Banez-Coronel, M.; Megias, D.; Lacal, J. C. Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism. Int. J. Oncol. 2005, 26, 999-1008.
-
(2005)
Int. J. Oncol
, vol.26
, pp. 999-1008
-
-
Rodriguez-Gonzalez, A.1
Ramirez de Molina, A.2
Banez-Coronel, M.3
Megias, D.4
Lacal, J.C.5
-
17
-
-
0038121109
-
Specificity of short interfering RNA determined through gene expression signatures
-
Semizarov, D.; Frost, L.; Sarthy, A.; Kroeger, P.; Halbert, D. N.; Fesik, S. W. Specificity of short interfering RNA determined through gene expression signatures. Proc. Natl. Acad. Sci. USA 2003, 100, 6347-6352.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6347-6352
-
-
Semizarov, D.1
Frost, L.2
Sarthy, A.3
Kroeger, P.4
Halbert, D.N.5
Fesik, S.W.6
-
18
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson, A. L.; Bartz, S. R.; Schelter, J.; Kobayashi, S. V.; Burchard, J.; Mao, M.; Li, B.; Cavet, G.; Linsley, P. S. Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. 2003, 21, 635-637.
-
(2003)
Nat. Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
19
-
-
0038798081
-
Genomewide view of gene silencing by small interfering RNAs
-
Chi, J. T.; Chang, H. Y.; Wang, N. N.; Chang, D. S.; Dunphy, N.; Brown, P. O. Genomewide view of gene silencing by small interfering RNAs. Proc. Natl. Acad. Sci. USA 2003, 100, 6343-6346.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 6343-6346
-
-
Chi, J.T.1
Chang, H.Y.2
Wang, N.N.3
Chang, D.S.4
Dunphy, N.5
Brown, P.O.6
-
20
-
-
34748865104
-
Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer
-
Gallego-Ortega, D.; Ramirez De Molina, A.; Gutierrez, R.; Ramos, M. A.; Sarmentero, J.; Cejas, P.; Nistal, M.; Gonzalez Baron, M.; Lacal, J. C. Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. Int. J. Oncol. 2006, 29, 335-340.
-
(2006)
Int. J. Oncol
, vol.29
, pp. 335-340
-
-
Gallego-Ortega, D.1
Ramirez De Molina, A.2
Gutierrez, R.3
Ramos, M.A.4
Sarmentero, J.5
Cejas, P.6
Nistal, M.7
Gonzalez Baron, M.8
Lacal, J.C.9
-
21
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, T. R.; Bernards, R.; Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002, 296, 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
22
-
-
0028168593
-
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
-
Wang, L.; Miura, M.; Bergeron, L.; Zhu, H.; Yuan, J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 1994, 78, 739-750.
-
(1994)
Cell
, vol.78
, pp. 739-750
-
-
Wang, L.1
Miura, M.2
Bergeron, L.3
Zhu, H.4
Yuan, J.5
-
23
-
-
0028102478
-
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
-
Lazebnik, Y. A.; Kaufmann, S. H.; Desnoyers, S.; Poirier, G. G.; Earnshaw, W. C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371, 346-347.
-
(1994)
Nature
, vol.371
, pp. 346-347
-
-
Lazebnik, Y.A.1
Kaufmann, S.H.2
Desnoyers, S.3
Poirier, G.G.4
Earnshaw, W.C.5
-
24
-
-
0027255417
-
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
-
Kaufmann, S. H.; Desnoyers, S.; Ottaviano, Y.; Davidson, N. E.; Poirier, G. G. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993, 53, 3976-3985.
-
(1993)
Cancer Res
, vol.53
, pp. 3976-3985
-
-
Kaufmann, S.H.1
Desnoyers, S.2
Ottaviano, Y.3
Davidson, N.E.4
Poirier, G.G.5
-
25
-
-
0035667397
-
The ons and offs of inducible transgenic technology: A review
-
Yamamoto, A.; Hen, R.;Dauer, W. T. The ons and offs of inducible transgenic technology: a review. Neurobiol. Dis. 2001, 8, 923-932.
-
(2001)
Neurobiol. Dis
, vol.8
, pp. 923-932
-
-
Yamamoto, A.1
Hen, R.2
Dauer, W.T.3
-
26
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen, M.; Freundlieb, S.; Bender, G.; Muller, G.; Hillen, W.; Bujard, H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995, 268, 1766-1769.
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
27
-
-
0036810923
-
Latest developments and in vivo use of the Tet system: Ex vivo and in vivo delivery of tetracycline-regulated genes
-
Corbel, S. Y.; Rossi, F. M. Latest developments and in vivo use of the Tet system: ex vivo and in vivo delivery of tetracycline-regulated genes. Curr. Opin. Biotechnol. 2002, 13, 448-452.
-
(2002)
Curr. Opin. Biotechnol
, vol.13
, pp. 448-452
-
-
Corbel, S.Y.1
Rossi, F.M.2
-
28
-
-
0033514443
-
Tet B or not tet B: Advances in tetracycline-inducible gene expression
-
Blau, H. M.; Rossi, F. M. Tet B or not tet B: advances in tetracycline-inducible gene expression. Proc. Natl. Acad. Sci. USA 1999, 96, 797-799.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 797-799
-
-
Blau, H.M.1
Rossi, F.M.2
-
29
-
-
0042268512
-
Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes
-
Berens, C.; Hillen, W. Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes. Eur. J. Biochem. 2003, 270, 3109-3121.
-
(2003)
Eur. J. Biochem
, vol.270
, pp. 3109-3121
-
-
Berens, C.1
Hillen, W.2
-
30
-
-
17944389830
-
-
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Fernandez, F.; Ramos, M. A.; Nunez M del, C.; Campos, J.; Lacal, J. C. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene 2003, 22, 8803-8812.
-
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Fernandez, F.; Ramos, M. A.; Nunez M del, C.; Campos, J.; Lacal, J. C. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene 2003, 22, 8803-8812.
-
-
-
-
31
-
-
0001715433
-
Choline kinase: A novel target for antitumor drugs
-
Lacal, J. C. Choline kinase: a novel target for antitumor drugs. IDrugs 2001, 4, 419-426.
-
(2001)
IDrugs
, vol.4
, pp. 419-426
-
-
Lacal, J.C.1
-
32
-
-
28244464886
-
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
-
Glunde, K.; Raman, V.; Mori, N.; Bhujwalla, Z. M. RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res. 2005, 65, 11034-11043.
-
(2005)
Cancer Res
, vol.65
, pp. 11034-11043
-
-
Glunde, K.1
Raman, V.2
Mori, N.3
Bhujwalla, Z.M.4
-
33
-
-
0030707480
-
Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family
-
Akahani, S.; Nangia-Makker, P.; Inohara, H.; Kim, H. R.; Raz, A. Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res. 1997, 57, 5272-5276.
-
(1997)
Cancer Res
, vol.57
, pp. 5272-5276
-
-
Akahani, S.1
Nangia-Makker, P.2
Inohara, H.3
Kim, H.R.4
Raz, A.5
-
34
-
-
0037300960
-
Galectins in cell growth and apoptosis
-
Yang, R. Y.; Liu, F. T. Galectins in cell growth and apoptosis. Cell. Mol. Life Sci. 2003, 60, 267-276.
-
(2003)
Cell. Mol. Life Sci
, vol.60
, pp. 267-276
-
-
Yang, R.Y.1
Liu, F.T.2
-
35
-
-
0036118467
-
Role of galectin-3 in breast cancer metastasis: Involvement of nitric oxide
-
Song, Y. K.; Billiar, T. R.; Lee, Y. J. Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide. Am. J. Pathol. 2002, 160, 1069-1075.
-
(2002)
Am. J. Pathol
, vol.160
, pp. 1069-1075
-
-
Song, Y.K.1
Billiar, T.R.2
Lee, Y.J.3
-
36
-
-
0033566695
-
Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells
-
Kim, H. R.; Lin, H. M.; Biliran, H.; Raz, A. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res. 1999, 59, 4148-4154.
-
(1999)
Cancer Res
, vol.59
, pp. 4148-4154
-
-
Kim, H.R.1
Lin, H.M.2
Biliran, H.3
Raz, A.4
-
37
-
-
11144237933
-
Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3
-
Choi, J. H.; Chun, K. H.; Raz, A.; Lotan, R. Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3. Cancer Biol. Ther. 2004, 3, 447-452.
-
(2004)
Cancer Biol. Ther
, vol.3
, pp. 447-452
-
-
Choi, J.H.1
Chun, K.H.2
Raz, A.3
Lotan, R.4
-
38
-
-
0028138771
-
Differentiation state and invasiveness of human breast cancer cell lines
-
Sommers, C. L.; Byers, S. W.; Thompson, E. W.; Torri, J. A.; Gelmann, E. P. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res. Treat. 1994, 31, 325-335.
-
(1994)
Breast Cancer Res. Treat
, vol.31
, pp. 325-335
-
-
Sommers, C.L.1
Byers, S.W.2
Thompson, E.W.3
Torri, J.A.4
Gelmann, E.P.5
-
39
-
-
0029809006
-
Vimentin expression is not associated with poor prognosis in breast cancer
-
Seshadri, R.; Raymond, W. A.; Leong, A. S.; Horsfall, D. J.; McCaul, K. Vimentin expression is not associated with poor prognosis in breast cancer. Int. J. Cancer 1996, 67, 353-356.
-
(1996)
Int. J. Cancer
, vol.67
, pp. 353-356
-
-
Seshadri, R.1
Raymond, W.A.2
Leong, A.S.3
Horsfall, D.J.4
McCaul, K.5
|