Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells

Cancer Research

Volumn 59, Issue 16, 1999, Pages 4148-4154

  Kim, Hyeong Reh Choi ^a,b   Lin, Huei Min ^a   Biliran, Hector ^a   Raz, Avraham ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALECTIN 3;

APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL ADHESION; CELL CYCLE; CELL CYCLE G1 PHASE; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOSIS INHIBITION; PRIORITY JOURNAL;

ANTIGENS, DIFFERENTIATION; APOPTOSIS; BREAST; CELL ADHESION; CELL CYCLE; CELL LINE; EPITHELIAL CELLS; FEMALE; GALECTIN 3; HUMANS;

EID: 0033566695     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Werb, Z., Ashkenas, J., MacAuley, A., and Wiesen, J. F. Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis. Braz. J. Med. Biol. Res., 29: 1087-1097, 1996.
2. Adams, J. C., and Watt, F. M. Regulation of development and differentiation by the extracellular matrix. Development (Camb.), 117: 1183-1198, 1993.
3. Lelievre, S., Weaver, V. M., and Bissell, M. J. Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation. Recent Prog. Horm. Res., 51: 417-432, 1996.
4. Hay, E. D. The cell biology of the extracellular matrix, Ed. 2. New York: Plenum Publishing Corp., 1992.
5. Tenniswood, M. P., Guenette, R. S., Lakins, J., Mooibroek, M., Wong, P., and Welsh, J. E. Active cell death in hormone-dependent tissues. Cancer Metastasis Rev., 11: 197-220, 1992.
6. Frisch, S. M., and Francis, H. Disruption of epithelial cell matrix interactions induces apoptosis. J. Cell Biol., 124: 619-626, 1994.
7. Hynes, R. O. Integrins: versatility, modulation, and signalling in cell adhesion. Cell, 69: 11-25, 1992.
8. Schwartz, M. A., Schaller, M. D., and Ginsberg, M. H. Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell. Dev. Biol., 11: 549-599, 1995.
9. Day, M. L., Foster, R. G., Day, K. C., Zhao, X., Humphrey, P., Swanson, P., Postigo, A. A., Zhang, S. H., and Dean D. C. Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway. J. Biol. Chem., 272: 8125-8128, 1997.
10. Frisch S. M., Vuori, K., Ruoslahti, E., and Chan-Hui, P. Y. Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol., 134: 793-799, 1996.
11. Zhu, X., Ohtsubo, M., Bohmer, R. M., Roberts, J. M., and Assoian, R. K. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E, cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol., 133: 391-403, 1996.
12. Raz, A., Pazerini, G., and Carmi, P. Identification of the metastasis-associated, galactoside-binding lectin as a chimeric gene product with homology to an IgE-binding protein. Cancer Res., 49: 3489-3493, 1989.
13. Lotan, R., Ito, H., Yasui, W., Yokozaki, H., Lotan, D., Tahara, E. Expression of a 31-kDa lactoside-binding in normal human gastric mucosa and in primary and metastatic gastric carcinomas. Int. J. Cancer, 56: 474-480, 1994.
14. Konstantinov, K. N., Robbins, B. A., and Liu, F-T. Galectin-3, a β-galactoside-binding animal lectin, is a marker of anaplastic larger cell lymphoma. Am. J. Pathol., 148: 25-30, 1996.
15. Nangia-Makker, P., Sarvis, R., Visscher, D. W., Bailey-Penrod, J., Raz, A., and Sarkar, F. H. Galectin-3 and L1 retrotransposons in human breast carcinomas. Breast Cancer Res. Treat., 49: 171-183, 1998.
16. Bresalier, R. S., Yan, P-S., Byrd, J. C., Lotan, R., and Raz, A. Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system. Cancer (Phila.), 80: 776-787, 1997.
17. Barondes, S. H., Castranovo, V., Cooper, D. N., Cummings, R. D., Drickamer, K., Feizi, T., Gitt, M. A., Hirabayashi, J., Hughes, C., Kasai, K., Leffler, H., Liu, F. T., Lotan, R., Mercurio, A. M., Monsigny, M., Pillai, S., Poirer, F., Raz, A., Rigby, P. W. J., Rini, J. M., and Wang, J. L., Galectins: a family of animal β-galactoside-binding lectins. Cell, 76: 597-598, 1994.
18. Yin, X-M., Oltavi, Z. N., and Korsmeyer, S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (Lond.), 369: 321-323, 1994.
19. Akahani, S., Nangia-Makker, P., Inohara, H., Kim, H-R. C., and Raz, A. Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res., 57: 5272-5276, 1997.
20. Yang, R-Y., Hsu, D. K., and Liu, F-T. Expression of galectin-3 modulates T-cell growth and apoptosis. Proc. Natl. Acad. Sci. USA, 93: 6737-6742, 1996.
21. Nangia-Makker, P., Thompson, E., Hogan, C., Ochieng, J., and Raz, A. Induction of tumorigenicity by galectin-3 in a non-tumorigenic human breast carcinoma cell line. Int. J. Oncol., 7: 1079-1087, 1995.
22. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (Lond.), 371: 346-347, 1994.
23. Deckwerth, T. L., and Johnson, E. M., Jr. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol., 123: 1207-1222, 1993.
24. Dulic, V., Lees, E., and Reed, S. I. Association of human cyclin E with a periodic G1-S phase protein kinase. Science (Washington DC), 257: 1958-1961, 1992.
25. Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70: 993-1006, 1992.
26. Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J. W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R., and Roberts, J. M. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science (Washington DC), 257: 1689-1694, 1992.
27. Girard, F., Strausfeld, U., Fernandez, A., and Lamb, N. J. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell, 67: 1169-1179, 1991.
28. Pagano, M., Pepperkok, R., Verde, F., Ansorge, W., and Draetta, G. Cyclin A is required at two points in the human cell cycle. EMBO J., 11: 961-971, 1992.
29. Zindy, F., Lamas, E., Chenivese, X., Sobczak, J., Wang, J., Fesquet, D., Henglein, B., and Brechot, C. Cyclin A is required in S phase in normal epithelial cells. Biochem. Biophys. Res Commun., 182: 1144-1154, 1992.
30. Chen, J., Jackson, P. K., Kirschner, M. W., and Dutta, A. Separate domains of p21 involved in the inhibition of cdk kinase and PCNA. Nature (Lond.), 374: 386-388, 1995.
31. Luo, Y., Hurwitz, J., and Massagué, J. Cell cycle inhibition by independent cdk and PCNA binding domains in p21cip1. Nature (Lond.), 375: 159-161, 1995.
32. Toyoshima, H., and Hunter, T. p27, a novel inhibitor of G1 cyclin and cdk protein kinase activity, is related to p21. Cell, 78: 67-74, 1994.
33. Dowdy, S. F., Hinds, P. W., Louie, K., Reed, S. I., Arnold, A., and Weinberg, R. A. Physical interaction of the retinoblastoma protein with human D cyclins. Cell, 73: 499-511, 1993.
34. 1 arrest. Cell, 76: 1013-1023, 1994.
35. Sherr, C. J., and Roberts, J. M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev., 9: 1149-1163, 1995.
36. Farquhar, M., and Palade, G. Junctional complexes in various epithelia. J. Cell. Biol., 17: 375-412, 1963.
37. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
38. Hengartner, M. O., and Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell, 76: 665-676, 1994.
39. Kroemer, G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med., 3: 614-620, 1997.
40. Baum, L. G., Pang, M., Perillo, N. L., Wu, T., Delegeane, A., Uittenbogaart, C. H., Fukuda, M., and Seilhamer, J. J. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med., 181: 877-887, 1995.
41. Perillo, N. L., Pace, K. E., Seilhamer J. J., and Baum, L. G. Apoptosis of T cells mediated by galectin-1. Nature (Lond.), 378: 736-739, 1995.
42. Perillo, N. L., Uittenbogaart, C. H., Nguyen, J. T., and Baum, L. G. Galectin-1, an endogenous lectin produced by thymic epithelial cells induces apoptosis in human thymocytes. J. Exp. Med., 185: 1851-1858, 1997.
43. Wada, J., Ota, K., Kumar, A., Wallner, E. I., and Kanwar, Y. S. Developmental regulation, expression and apoptotic potential of galectin-9, a β-galactoside binding lectin. J. Clin. Invest., 99: 2452-2461, 1997.
44. Kadrofske, M. M., Openo, K. P., and Wang, J. L. The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter. Arch. Biochem. Biophys., 349: 7-20, 1998.
45. Gray-Bablin, J., Zalvide, J., Fox, M. P., Knickerbocker, C. J., DeCaprio, J. A., and Keyomarsi, K. Cyclin E, a redundant cyclin in breast cancer. Proc. Natl. Acad. Sci. USA, 93: 15215-15220, 1996.
46. Hatakeyama, M., Brill, J. A., Fink, G. R., and Weinberg, R. A. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev., 8: 1759-1771, 1994.
47. Labaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. New functional activities for the p21 family of CDK inhibitors. Genes Dev., 11: 847-862, 1997.
48. Lammie, G. A., Fantl, V., Smith, R., Schuuring, E., Brookes, S., Michalides, R., Dickson, C., Arnold, A., and Peters, G. D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1. Oncogene, 6: 439-444, 1991.
49. Schuuring, E., Verhoeven, E., Mooi, W. J., and Michalides, J. A. M. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene, 7: 355-361, 1992.
50. Jiang, W., Kahn, S. M., Tomita, N., Zhang, Y. J., Lu, S. H., and Weinstein, I. B. Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res., 52: 2980-2983, 1992.
51. 1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA, 90: 9026-9030, 1993.
52. Berenson, J. R., Koga, H., Yang, J., Pearl, J., Holmes, E. C., and Figlin, R. Frequent amplification of the bcl-1 locus in poorly differentiated squamous cell carcinoma of the lung. The Lung Cancer Study Group. Oncogene, 5: 1343-1348, 1990.
53. 1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities. Cancer Res., 57: 5542-5549, 1997.
54. Wang, L., Inohara, H., Pienta, K. J., and Raz, A. Galectin-3 is a nuclear matrix protein which binds RNA. Biochem. Biophys. Res. Commun., 217: 292-303, 1995.
55. Dagher, S. F., Wang, J. L., and Patterson, R. J. Identification of galectin-3 as a factor in pre-mRNA splicing. Proc. Natl. Acad. Sci. USA, 92: 1213-1217, 1995.
56. Guan, J-L., and Shalloway, D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (Lond.), 358: 690-692, 1992.
57. Lipfert, L., Haimovich, B., Schaller, M. D., Cobb, B. S., Parsons, J. T., and Brugge, J. S. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J. Cell Biol., 119: 905-912, 1992.
58. Zhao, J. H., Reiske, H., and Guan, J. L. Regulation of the cell cycle by focal adhesion kinase. J. Cell Biol., 143: 1997-2008, 1998.