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Volumn 4, Issue 4, 2001, Pages 419-426

Choline kinase: A novel target for antitumor drugs

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EID: 0001715433     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (78)

References (89)
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    • • The authors demonstrated that elevated levels of DAG in ras-transformed cells were generated not by the hydrolysis of Pi-containing phospholipids, but from the hydrolysis of phosphatidylcholine. The paper also provided the basis for a better understanding of the role of the lipid-derived metabolites in mitogenic signaling after transformation by Pas oncoproleins.
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    • Moscat J and Aaronson SA: Novel Source of 1,2diacylglicerol Elevated in Cells Transformed by Ha-ras Oncogene
    • Lacal, J.C.1
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    • Macara IG: Elevated phosphocholine concentration in ras-transformed NIH3T3 cells arises from increase choline kinase activity, not from phosphatidylcholine breakdown. Mol Cell Bio (1989) 9:325-328.
    • Not from Phosphatidylcholine Breakdown.
    • Macara, I.G.1
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    • (1993) 8:2959-2968. • This paper provided the first time demonstration of the mitogenic activity of PCho, establishing a link between growth factor- and oncogene-induced cell proliferation. The study also provided the basis for oncogene-driven transformation as a consequence of an unbalance of lipid metabolites
    • Cuadrado A, Camera A, Dolfi F, Jiménez B, Lacal JC. Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene (1993) 8:2959-2968. • This paper provided the first time demonstration of the mitogenic activity of PCho, establishing a link between growth factor- and oncogene-induced cell proliferation. The study also provided the basis for oncogene-driven transformation as a consequence of an unbalance of lipid metabolites:
    • Camera A, Dolfi F, Jiménez B, Lacal JC. Phosphorylcholine: A Novel Second Messenger Essential for Mitogenic Activity of Growth Factors. Oncogene
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    • • This manuscript demonstrates a dear correlation between an increase in PCho levels and transformation in human tumors. Furthermore, it demonstrates that this is independent of cell proliferation status. It establishes solid grounds for the analysis, by NMR, of the levels of PCho in human tumors as a valid diagnostic strategy to correlate with the transforming phenotype.
    • Bhakoo KK, ' Williams SR, Florian CL, Und H, Noble M: Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res (1996) 56:4630-4635. • This manuscript demonstrates a dear correlation between an increase in PCho levels and transformation in human tumors. Furthermore, it demonstrates that this is independent of cell proliferation status. It establishes solid grounds for the analysis, by NMR, of the levels of PCho in human tumors as a valid diagnostic strategy to correlate with the transforming phenotype.
    • ' Williams SR, Florian CL, und H, Noble M: Immortalization and Transformation Are Associated with Specific Alterations in Choline Metabolism. Cancer Res (1996) 56:4630-4635.
    • Bhakoo, K.K.1
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  • 85
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    • Excellent review that provides full information on the structure and properties of the choline kinase inhibitor hemicholinium-3 and its derivatives.
    • Cannon JG: Structure-activity aspects of hemicholinium-3 (HC-3) and its analogues and congeners. Med Res Rev (1994) 14(5):505531. Excellent review that provides full information on the structure and properties of the choline kinase inhibitor hemicholinium-3 and its derivatives.
    • Cannon, J.G.1    Analogues, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.