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Volumn 300, Issue 22, 2008, Pages 2638-2646

Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy

Author keywords

[No Author keywords available]

Indexed keywords

AMBRISENTAN; APOLIPOPROTEIN; APOLIPOPROTEIN A1; ARGINASE; ARGININE; BOSENTAN; CARBON MONOXIDE; CYCLIC GMP; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; HEME OXYGENASE 1; HEMOGLOBIN; LACTATE DEHYDROGENASE; N(G),N(G) DIMETHYLARGININE; NICOTINIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; SITAXSENTAN; SODIUM NITRITE;

EID: 57449112518     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2008.598     Document Type: Review
Times cited : (80)

References (82)
  • 1
    • 10744233940 scopus 로고    scopus 로고
    • Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    • Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med. 2004;350(9):886-895.
    • (2004) N Engl J Med , vol.350 , Issue.9 , pp. 886-895
    • Gladwin, M.T.1    Sachdev, V.2    Jison, M.L.3
  • 2
    • 33746040474 scopus 로고    scopus 로고
    • N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease
    • Machado RF, Anthi A, Steinberg MH, et al. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA. 2006;296(3):310-318.
    • (2006) JAMA , vol.296 , Issue.3 , pp. 310-318
    • Machado, R.F.1    Anthi, A.2    Steinberg, M.H.3
  • 3
    • 0025797297 scopus 로고
    • Stroke in sickle cell disease: Demographic, clinical, and therapeutic considerations
    • Ohene-Frempong K. Stroke in sickle cell disease: demographic, clinical, and therapeutic considerations. Semin Hematol. 1991;28(3):213-219.
    • (1991) Semin Hematol , vol.28 , Issue.3 , pp. 213-219
    • Ohene-Frempong, K.1
  • 4
    • 33846279380 scopus 로고    scopus 로고
    • Deconstructing sickle cell disease: Reappraisal of the role of hemolysis in the development of clinical subphenotypes
    • Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev. 2007;21(1):37-47.
    • (2007) Blood Rev , vol.21 , Issue.1 , pp. 37-47
    • Kato, G.J.1    Gladwin, M.T.2    Steinberg, M.H.3
  • 5
    • 33947153000 scopus 로고    scopus 로고
    • Sickle cell trait and sudden death-bringing it home
    • Mitchell BL. Sickle cell trait and sudden death-bringing it home. J Natl Med Assoc. 2007;99(3):300-305.
    • (2007) J Natl Med Assoc , vol.99 , Issue.3 , pp. 300-305
    • Mitchell, B.L.1
  • 6
    • 57449083015 scopus 로고    scopus 로고
    • Mechanisms and clinical complications of hemolysis in sickle cell disease and thalassemia
    • Steinberg MH, Forget BG, Higgs DR, Nagel RL, eds, 2nd ed. New York, NY: Cambridge University Press; In press
    • Kato GJ, Gladwin MT. Mechanisms and clinical complications of hemolysis in sickle cell disease and thalassemia. In: Steinberg MH, Forget BG, Higgs DR, Nagel RL, eds. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. 2nd ed. New York, NY: Cambridge University Press; In press.
    • Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management
    • Kato, G.J.1    Gladwin, M.T.2
  • 7
    • 0036908599 scopus 로고    scopus 로고
    • Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
    • Reiter CD, Wang X, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med. 2002;8(12):1383-1389.
    • (2002) Nat Med , vol.8 , Issue.12 , pp. 1383-1389
    • Reiter, C.D.1    Wang, X.2    Tanus-Santos, J.E.3
  • 8
    • 14244257951 scopus 로고    scopus 로고
    • Pulmonary hypertension in sickle cell disease
    • Ataga KI, Sood N, De GG, et al. Pulmonary hypertension in sickle cell disease. Am J Med. 2004;117(9):665-669.
    • (2004) Am J Med , vol.117 , Issue.9 , pp. 665-669
    • Ataga, K.I.1    Sood, N.2    De, G.G.3
  • 9
    • 38349071895 scopus 로고    scopus 로고
    • Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes
    • DeCastro LM, Jonassaint JC, Graham FL, Ashley-Koch A, Telen MJ. Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes. Am J Hematol. 2008;83(1):19-25.
    • (2008) Am J Hematol , vol.83 , Issue.1 , pp. 19-25
    • DeCastro, L.M.1    Jonassaint, J.C.2    Graham, F.L.3    Ashley-Koch, A.4    Telen, M.J.5
  • 10
    • 20044386727 scopus 로고    scopus 로고
    • Chronic sickle cell lung disease: New insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension
    • Machado RF, Gladwin MT. Chronic sickle cell lung disease: new insights into the diagnosis, pathogenesis and treatment of pulmonary hypertension. Br J Haematol. 2005;129(4):449-464.
    • (2005) Br J Haematol , vol.129 , Issue.4 , pp. 449-464
    • Machado, R.F.1    Gladwin, M.T.2
  • 11
    • 33744810662 scopus 로고    scopus 로고
    • Pulmonary hypertension in patients with sickle cell disease: A longitudinal study
    • Ataga KI, Moore CG, Jones S, et al. Pulmonary hypertension in patients with sickle cell disease: a longitudinal study. Br J Haematol. 2006;134(1):109-115.
    • (2006) Br J Haematol , vol.134 , Issue.1 , pp. 109-115
    • Ataga, K.I.1    Moore, C.G.2    Jones, S.3
  • 12
    • 33846338501 scopus 로고    scopus 로고
    • Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease
    • Sachdev V, Machado RF, Shizukuda Y, et al. Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. J Am Coll Cardiol. 2007;49(4):472-479.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.4 , pp. 472-479
    • Sachdev, V.1    Machado, R.F.2    Shizukuda, Y.3
  • 13
    • 40949129196 scopus 로고    scopus 로고
    • Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease
    • Mekontso Dessap A, Leon R, Habibi A, et al. Pulmonary hypertension and cor pulmonale during severe acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med. 2008;177(6):646-653.
    • (2008) Am J Respir Crit Care Med , vol.177 , Issue.6 , pp. 646-653
    • Mekontso Dessap, A.1    Leon, R.2    Habibi, A.3
  • 14
    • 33845910404 scopus 로고    scopus 로고
    • Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease
    • Machado RF, Mack AK, Martyr S, et al. Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease. Br J Haematol. 2007;136(2):319-325.
    • (2007) Br J Haematol , vol.136 , Issue.2 , pp. 319-325
    • Machado, R.F.1    Mack, A.K.2    Martyr, S.3
  • 15
    • 21444441271 scopus 로고    scopus 로고
    • Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease
    • Morris CR, Kato GJ, Poljakovic M, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. JAMA. 2005;294(1):81-90.
    • (2005) JAMA , vol.294 , Issue.1 , pp. 81-90
    • Morris, C.R.1    Kato, G.J.2    Poljakovic, M.3
  • 16
    • 2542490292 scopus 로고    scopus 로고
    • Evidence for a metabolic shift of arginine metabolism in sickle cell disease
    • Schnog JJ, Jager EH, van der Dijs FP, et al. Evidence for a metabolic shift of arginine metabolism in sickle cell disease. Ann Hematol. 2004;83(6):371-375.
    • (2004) Ann Hematol , vol.83 , Issue.6 , pp. 371-375
    • Schnog, J.J.1    Jager, E.H.2    van der Dijs, F.P.3
  • 17
    • 33644775612 scopus 로고    scopus 로고
    • Lactate dehydrogenase as a biomarker of hemolysisassociated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease
    • Kato GJ, McGowan VR, Machado RF, et al. Lactate dehydrogenase as a biomarker of hemolysisassociated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease. Blood. 2006;107(6):2279-2285.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2279-2285
    • Kato, G.J.1    McGowan, V.R.2    Machado, R.F.3
  • 18
    • 23244453721 scopus 로고    scopus 로고
    • Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease
    • Schnog JB, Teerlink T, van der Dijs FP, Duits AJ, Muskiet FA. Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease. Ann Hematol. 2005;84(5):282-286.
    • (2005) Ann Hematol , vol.84 , Issue.5 , pp. 282-286
    • Schnog, J.B.1    Teerlink, T.2    van der Dijs, F.P.3    Duits, A.J.4    Muskiet, F.A.5
  • 19
    • 45749100959 scopus 로고    scopus 로고
    • CURAMA Study Group. Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis
    • Landburg PP, Teerlink T, Muskiet FA, Duits AJ, Schnog JJ; CURAMA Study Group. Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis. Am J Hematol. 2008;83(7):577-579.
    • (2008) Am J Hematol , vol.83 , Issue.7 , pp. 577-579
    • Landburg, P.P.1    Teerlink, T.2    Muskiet, F.A.3    Duits, A.J.4    Schnog, J.J.5
  • 20
    • 0022595156 scopus 로고
    • Decreased apolipoprotein A-I and B content in plasma of individuals with sickle cell anemia
    • Sasaki J, Waterman MR, Cottam GL. Decreased apolipoprotein A-I and B content in plasma of individuals with sickle cell anemia. Clin Chem. 1986;32(1 pt 1):226-227.
    • (1986) Clin Chem , vol.32 , Issue.1 PART 1 , pp. 226-227
    • Sasaki, J.1    Waterman, M.R.2    Cottam, G.L.3
  • 22
    • 60849135703 scopus 로고    scopus 로고
    • Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease
    • In press
    • Yuditskaya S, Tumblin A, Hoehn GT, et al. Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease. Blood. In press.
    • Blood
    • Yuditskaya, S.1    Tumblin, A.2    Hoehn, G.T.3
  • 23
    • 0037986617 scopus 로고    scopus 로고
    • L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease
    • Ou J, Ou Z, Jones DW, et al. L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. Circulation. 2003;107(18):2337-2341.
    • (2003) Circulation , vol.107 , Issue.18 , pp. 2337-2341
    • Ou, J.1    Ou, Z.2    Jones, D.W.3
  • 24
    • 0031877983 scopus 로고    scopus 로고
    • Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy
    • Saleh AW, Duits AJ, Gerbers A, de Vries C, Hillen HF. Cytokines and soluble adhesion molecules in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol. 1998;100(1):26-31.
    • (1998) Acta Haematol , vol.100 , Issue.1 , pp. 26-31
    • Saleh, A.W.1    Duits, A.J.2    Gerbers, A.3    de Vries, C.4    Hillen, H.F.5
  • 26
    • 0038690566 scopus 로고    scopus 로고
    • Erythropoiesis and serum sVCAM-1 levels in adults with sickle cell disease
    • Duits AJ, Rojer RA, van Endt T, et al. Erythropoiesis and serum sVCAM-1 levels in adults with sickle cell disease. Ann Hematol. 2003;82(3):171-174.
    • (2003) Ann Hematol , vol.82 , Issue.3 , pp. 171-174
    • Duits, A.J.1    Rojer, R.A.2    van Endt, T.3
  • 27
    • 3342982985 scopus 로고    scopus 로고
    • Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea
    • Conran N, Fattori A, Saad ST, Costa FF. Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea.AmJ Hematol. 2004;76(4):343-347.
    • (2004) AmJ Hematol , vol.76 , Issue.4 , pp. 343-347
    • Conran, N.1    Fattori, A.2    Saad, S.T.3    Costa, F.F.4
  • 28
    • 0005991370 scopus 로고    scopus 로고
    • Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis
    • Duits AJ, Pieters RC, Saleh AW, et al. Enhanced levels of soluble VCAM-1 in sickle cell patients and their specific increment during vasoocclusive crisis. Clin Immunol Immunopathol. 1996;81(1):96-98.
    • (1996) Clin Immunol Immunopathol , vol.81 , Issue.1 , pp. 96-98
    • Duits, A.J.1    Pieters, R.C.2    Saleh, A.W.3
  • 29
    • 17444409954 scopus 로고    scopus 로고
    • Plasma levels of tissue factor and soluble Eselectin in sickle cell disease: Relationship to genotype and to inflammation
    • Mohan JS, Lip GY, Wright J, Bareford D, Blann AD. Plasma levels of tissue factor and soluble Eselectin in sickle cell disease: relationship to genotype and to inflammation. Blood Coagul Fibrinolysis. 2005;16(3):209-214.
    • (2005) Blood Coagul Fibrinolysis , vol.16 , Issue.3 , pp. 209-214
    • Mohan, J.S.1    Lip, G.Y.2    Wright, J.3    Bareford, D.4    Blann, A.D.5
  • 30
    • 0242266583 scopus 로고    scopus 로고
    • Hypoxaemia in sickle cell disease: Biomarker modulation and relevance to pathophysiology
    • Setty BN, Stuart MJ, Dampier C, Brodecki D, Allen JL. Hypoxaemia in sickle cell disease: biomarker modulation and relevance to pathophysiology. Lancet. 2003;362(9394):1450-1455.
    • (2003) Lancet , vol.362 , Issue.9394 , pp. 1450-1455
    • Setty, B.N.1    Stuart, M.J.2    Dampier, C.3    Brodecki, D.4    Allen, J.L.5
  • 31
    • 27244435213 scopus 로고    scopus 로고
    • Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality
    • Kato GJ, Martyr S, Blackwelder WC, et al. Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. Br J Haematol. 2005;130(6):943-953.
    • (2005) Br J Haematol , vol.130 , Issue.6 , pp. 943-953
    • Kato, G.J.1    Martyr, S.2    Blackwelder, W.C.3
  • 32
    • 45749141769 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: Clinical characteristics and association with soluble adhesion molecule expression
    • Klings ES, Anton Bland D, Rosenman D, et al. Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression. Am J Hematol. 2008;83(7):547-553.
    • (2008) Am J Hematol , vol.83 , Issue.7 , pp. 547-553
    • Klings, E.S.1    Anton Bland, D.2    Rosenman, D.3
  • 33
    • 8644256005 scopus 로고    scopus 로고
    • The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo
    • Embury SH, Matsui NM, Ramanujam S, et al. The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood. 2004;104(10):3378-3385.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3378-3385
    • Embury, S.H.1    Matsui, N.M.2    Ramanujam, S.3
  • 34
    • 0033624253 scopus 로고    scopus 로고
    • Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice
    • Kaul DK, Hebbel RP. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J Clin Invest. 2000;106(3):411-420.
    • (2000) J Clin Invest , vol.106 , Issue.3 , pp. 411-420
    • Kaul, D.K.1    Hebbel, R.P.2
  • 35
    • 0037588990 scopus 로고    scopus 로고
    • Transgenic sickle mice have vascular inflammation
    • Belcher JD, Bryant CJ, Nguyen J, et al. Transgenic sickle mice have vascular inflammation. Blood. 2003;101(10):3953-3959.
    • (2003) Blood , vol.101 , Issue.10 , pp. 3953-3959
    • Belcher, J.D.1    Bryant, C.J.2    Nguyen, J.3
  • 36
    • 0029817660 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: Potential role in sickle cell disease
    • Setty BN, Stuart MJ. Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood. 1996;88(6):2311-2320.
    • (1996) Blood , vol.88 , Issue.6 , pp. 2311-2320
    • Setty, B.N.1    Stuart, M.J.2
  • 37
    • 0036280031 scopus 로고    scopus 로고
    • Neutrophils and leucocyte adhesion molecules in sickle cell retinopathy
    • Kunz Mathews M, McLeod DS, Merges C, Cao J, Lutty GA. Neutrophils and leucocyte adhesion molecules in sickle cell retinopathy. Br J Ophthalmol. 2002;86(6):684-690.
    • (2002) Br J Ophthalmol , vol.86 , Issue.6 , pp. 684-690
    • Kunz Mathews, M.1    McLeod, D.S.2    Merges, C.3    Cao, J.4    Lutty, G.A.5
  • 38
    • 33751092291 scopus 로고    scopus 로고
    • Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vasoocclusion in the microcirculation
    • Kaul DK, Liu XD, Zhang X, et al. Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vasoocclusion in the microcirculation. Am J Physiol Cell Physiol. 2006;291(5):C922-C930.
    • (2006) Am J Physiol Cell Physiol , vol.291 , Issue.5
    • Kaul, D.K.1    Liu, X.D.2    Zhang, X.3
  • 39
    • 0041308074 scopus 로고    scopus 로고
    • Inflammatory mediators promote strong sickle cell adherence to endothelium under venular flow conditions
    • Walmet PS, Eckman JR, Wick TM. Inflammatory mediators promote strong sickle cell adherence to endothelium under venular flow conditions. Am J Hematol. 2003;73(4):215-224.
    • (2003) Am J Hematol , vol.73 , Issue.4 , pp. 215-224
    • Walmet, P.S.1    Eckman, J.R.2    Wick, T.M.3
  • 40
    • 38349151904 scopus 로고    scopus 로고
    • Microvascular endothelial cells express a phosphatidylserine receptor: A functionally active receptor for phosphatidylserine-positive erythrocytes
    • Setty BN, Betal SG. Microvascular endothelial cells express a phosphatidylserine receptor: a functionally active receptor for phosphatidylserine-positive erythrocytes. Blood. 2008;111(2):905-914.
    • (2008) Blood , vol.111 , Issue.2 , pp. 905-914
    • Setty, B.N.1    Betal, S.G.2
  • 41
    • 21144440415 scopus 로고    scopus 로고
    • Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice
    • Belcher JD, Mahaseth H, Welch TE, et al. Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice. Am J Physiol Heart Circ Physiol. 2005;288(6):H2715-H2725.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , Issue.6
    • Belcher, J.D.1    Mahaseth, H.2    Welch, T.E.3
  • 43
    • 0035885941 scopus 로고    scopus 로고
    • P-selectin mediates the adhesion of sickle erythrocytes to the endothelium
    • Matsui NM, Borsig L, Rosen SD, Yaghmai M, Varki A, Embury SH. P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood. 2001;98(6):1955-1962.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1955-1962
    • Matsui, N.M.1    Borsig, L.2    Rosen, S.D.3    Yaghmai, M.4    Varki, A.5    Embury, S.H.6
  • 44
    • 0030001831 scopus 로고    scopus 로고
    • Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
    • Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol. 1996;156(7):2558-2565.
    • (1996) J Immunol , vol.156 , Issue.7 , pp. 2558-2565
    • Haraldsen, G.1    Kvale, D.2    Lien, B.3    Farstad, I.N.4    Brandtzaeg, P.5
  • 45
    • 0031748618 scopus 로고    scopus 로고
    • Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants
    • Spiecker M, Darius H, Kaboth K, Hubner F, Liao JK. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol. 1998;63(6):732-739.
    • (1998) J Leukoc Biol , vol.63 , Issue.6 , pp. 732-739
    • Spiecker, M.1    Darius, H.2    Kaboth, K.3    Hubner, F.4    Liao, J.K.5
  • 46
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R, Libby P, Peng HB, et al. Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest. 1995;96(1):60-68.
    • (1995) J Clin Invest , vol.96 , Issue.1 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3
  • 47
    • 0030295229 scopus 로고    scopus 로고
    • Nitric oxide attenuates adhesion molecule expression in human endothelial cells
    • Takahashi M, Ikeda U, Masuyama J, Funayama H, Kano S, Shimada K. Nitric oxide attenuates adhesion molecule expression in human endothelial cells. Cytokine. 1996;8(11):817-821.
    • (1996) Cytokine , vol.8 , Issue.11 , pp. 817-821
    • Takahashi, M.1    Ikeda, U.2    Masuyama, J.3    Funayama, H.4    Kano, S.5    Shimada, K.6
  • 48
    • 0031572303 scopus 로고    scopus 로고
    • Endothelial cell adhesion molecule expression and lymphocyte adhesion to endothelial cells: Effect of nitric oxide
    • Cartwright JE, Whitley GS, Johnstone AP. Endothelial cell adhesion molecule expression and lymphocyte adhesion to endothelial cells: effect of nitric oxide. Exp Cell Res. 1997;235(2):431-434.
    • (1997) Exp Cell Res , vol.235 , Issue.2 , pp. 431-434
    • Cartwright, J.E.1    Whitley, G.S.2    Johnstone, A.P.3
  • 49
    • 0034102968 scopus 로고    scopus 로고
    • Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium
    • Space SL, Lane PA, Pickett CK, Weil JV. Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium.AmJ Hematol. 2000;63(4):200-204.
    • (2000) AmJ Hematol , vol.63 , Issue.4 , pp. 200-204
    • Space, S.L.1    Lane, P.A.2    Pickett, C.K.3    Weil, J.V.4
  • 50
    • 0036225924 scopus 로고    scopus 로고
    • Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells: Role of cyclic GMP and NF-kappaB
    • Lee SK, Kim JH, Yang WS, Kim SB, Park SK, Park JS. Exogenous nitric oxide inhibits VCAM-1 expression in human peritoneal mesothelial cells: role of cyclic GMP and NF-kappaB. Nephron. 2002;90(4):447-454.
    • (2002) Nephron , vol.90 , Issue.4 , pp. 447-454
    • Lee, S.K.1    Kim, J.H.2    Yang, W.S.3    Kim, S.B.4    Park, S.K.5    Park, J.S.6
  • 51
    • 0020503046 scopus 로고
    • Platelet activation during steady state sickle cell disease
    • Westwick J, Watson-Williams EJ, Krishnamurthi S, et al. Platelet activation during steady state sickle cell disease. J Med. 1983;14(1):17-36.
    • (1983) J Med , vol.14 , Issue.1 , pp. 17-36
    • Westwick, J.1    Watson-Williams, E.J.2    Krishnamurthi, S.3
  • 52
    • 0031930422 scopus 로고    scopus 로고
    • Platelet activation in patients with sickle cell disease
    • Wun T, Paglieroni T, Rangaswami A, et al. Platelet activation in patients with sickle cell disease. Br J Haematol. 1998;100(4):741-749.
    • (1998) Br J Haematol , vol.100 , Issue.4 , pp. 741-749
    • Wun, T.1    Paglieroni, T.2    Rangaswami, A.3
  • 53
    • 34548821573 scopus 로고    scopus 로고
    • Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension and nitric oxide scavenging by cell-free hemoglobin
    • Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ. Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension and nitric oxide scavenging by cell-free hemoglobin. Blood. 2007;110(6):2166-2172.
    • (2007) Blood , vol.110 , Issue.6 , pp. 2166-2172
    • Villagra, J.1    Shiva, S.2    Hunter, L.A.3    Machado, R.F.4    Gladwin, M.T.5    Kato, G.J.6
  • 54
    • 38549131853 scopus 로고    scopus 로고
    • Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension
    • Ataga KI, Moore CG, Hillery CA, et al. Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension. Haematologica. 2008;93(1):20-26.
    • (2008) Haematologica , vol.93 , Issue.1 , pp. 20-26
    • Ataga, K.I.1    Moore, C.G.2    Hillery, C.A.3
  • 55
    • 43449096658 scopus 로고    scopus 로고
    • No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension
    • van Beers EJ, Spronk HM, Ten Cate H, et al. No association of the hypercoagulable state with sickle cell disease related pulmonary hypertension. Haematologica. 2008;93(5):e42-e44.
    • (2008) Haematologica , vol.93 , Issue.5
    • van Beers, E.J.1    Spronk, H.M.2    Ten Cate, H.3
  • 56
    • 0035101534 scopus 로고    scopus 로고
    • Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease
    • Nath KA, Grande JP, Haggard JJ, et al. Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Am J Pathol. 2001;158(3):893-903.
    • (2001) Am J Pathol , vol.158 , Issue.3 , pp. 893-903
    • Nath, K.A.1    Grande, J.P.2    Haggard, J.J.3
  • 57
    • 3042799335 scopus 로고    scopus 로고
    • Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease
    • Jison ML, Munson PJ, Barb JJ, et al. Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease. Blood. 2004;104(1):270-280.
    • (2004) Blood , vol.104 , Issue.1 , pp. 270-280
    • Jison, M.L.1    Munson, P.J.2    Barb, J.J.3
  • 60
    • 3242792093 scopus 로고    scopus 로고
    • The endothelial biology of sickle cell disease: Inflammation and a chronic vasculopathy
    • Hebbel RP, Osarogiagbon R, Kaul D. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation. 2004;11(2):129-151.
    • (2004) Microcirculation , vol.11 , Issue.2 , pp. 129-151
    • Hebbel, R.P.1    Osarogiagbon, R.2    Kaul, D.3
  • 61
    • 31044445795 scopus 로고    scopus 로고
    • Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin
    • Minneci PC, Deans KJ, Zhi H, et al. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005;115(12):3409-3417.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3409-3417
    • Minneci, P.C.1    Deans, K.J.2    Zhi, H.3
  • 62
    • 0037420269 scopus 로고    scopus 로고
    • Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease
    • Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, Brugnara C. Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA. 2003;289(9):1136-1142.
    • (2003) JAMA , vol.289 , Issue.9 , pp. 1136-1142
    • Weiner, D.L.1    Hibberd, P.L.2    Betit, P.3    Cooper, A.B.4    Botelho, C.A.5    Brugnara, C.6
  • 63
    • 10744220361 scopus 로고    scopus 로고
    • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    • Cosby K, Partovi KS, Crawford JH, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003;9(12):1498-1505.
    • (2003) Nat Med , vol.9 , Issue.12 , pp. 1498-1505
    • Cosby, K.1    Partovi, K.S.2    Crawford, J.H.3
  • 64
    • 33947728687 scopus 로고    scopus 로고
    • Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    • Shiva S, Huang Z, Grubina R, et al. Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res. 2007;100(5):654-661.
    • (2007) Circ Res , vol.100 , Issue.5 , pp. 654-661
    • Shiva, S.1    Huang, Z.2    Grubina, R.3
  • 65
    • 38849162730 scopus 로고    scopus 로고
    • The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7(2):156-167.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.2 , pp. 156-167
    • Lundberg, J.O.1    Weitzberg, E.2    Gladwin, M.T.3
  • 66
    • 46649108907 scopus 로고    scopus 로고
    • Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthasedeficient mice
    • Bryan NS, Calvert JW, Gundewar S, Lefer DJ. Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthasedeficient mice. Free Radic Biol Med. 2008;45(4):468-474.
    • (2008) Free Radic Biol Med , vol.45 , Issue.4 , pp. 468-474
    • Bryan, N.S.1    Calvert, J.W.2    Gundewar, S.3    Lefer, D.J.4
  • 67
    • 46249130703 scopus 로고    scopus 로고
    • Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    • Gonzalez FM, Shiva S, Vincent PS, et al. Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation. 2008;117(23):2986-2994.
    • (2008) Circulation , vol.117 , Issue.23 , pp. 2986-2994
    • Gonzalez, F.M.1    Shiva, S.2    Vincent, P.S.3
  • 68
    • 20944446791 scopus 로고    scopus 로고
    • Cytoprotective effects of nitrite during in vivo ischemiareperfusion of the heart and liver
    • Duranski MR, Greer JJ, Dejam A, et al. Cytoprotective effects of nitrite during in vivo ischemiareperfusion of the heart and liver. J Clin Invest. 2005;115(5):1232-1240.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1232-1240
    • Duranski, M.R.1    Greer, J.J.2    Dejam, A.3
  • 69
    • 15044344420 scopus 로고    scopus 로고
    • Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage
    • Pluta RM, Dejam A, Grimes G, Gladwin MT, Oldfield EH. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA. 2005;293(12):1477-1484.
    • (2005) JAMA , vol.293 , Issue.12 , pp. 1477-1484
    • Pluta, R.M.1    Dejam, A.2    Grimes, G.3    Gladwin, M.T.4    Oldfield, E.H.5
  • 71
    • 50049113011 scopus 로고    scopus 로고
    • Sodium Nitrite Promotes Regional Blood Flow in Patients with Sickle Cell Disease: A Phase I/II Study
    • Mack AK, McGowan VR, Tremonti CK, et al. Sodium Nitrite Promotes Regional Blood Flow in Patients with Sickle Cell Disease: A Phase I/II Study. Br J Haematol. 2008;142(6):971-978.
    • (2008) Br J Haematol , vol.142 , Issue.6 , pp. 971-978
    • Mack, A.K.1    McGowan, V.R.2    Tremonti, C.K.3
  • 72
    • 23644460670 scopus 로고    scopus 로고
    • Enzymatic function of hemoglobin as a nitrite reductase that producesNOunder allosteric control
    • Huang Z, Shiva S, Kim-Shapiro DB, et al. Enzymatic function of hemoglobin as a nitrite reductase that producesNOunder allosteric control. J Clin Invest. 2005;115(8):2099-2107.
    • (2005) J Clin Invest , vol.115 , Issue.8 , pp. 2099-2107
    • Huang, Z.1    Shiva, S.2    Kim-Shapiro, D.B.3
  • 73
    • 52449103584 scopus 로고    scopus 로고
    • Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis
    • Minneci PC, Deans KJ, Shiva S, et al. Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. Am J Physiol Heart Circ Physiol. 2008;295(2):H743-H754.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295 , Issue.2
    • Minneci, P.C.1    Deans, K.J.2    Shiva, S.3
  • 74
    • 33751530487 scopus 로고    scopus 로고
    • Protective effect of arginine on oxidative stress in transgenic sickle mouse models
    • Dasgupta T, Hebbel RP, Kaul DK. Protective effect of arginine on oxidative stress in transgenic sickle mouse models. Free Radic Biol Med. 2006;41(12):1771-1780.
    • (2006) Free Radic Biol Med , vol.41 , Issue.12 , pp. 1771-1780
    • Dasgupta, T.1    Hebbel, R.P.2    Kaul, D.K.3
  • 75
    • 0037082452 scopus 로고    scopus 로고
    • Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity
    • Romero JR, Suzuka SM, Nagel RL, Fabry ME. Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity. Blood. 2002;99(4):1103-1108.
    • (2002) Blood , vol.99 , Issue.4 , pp. 1103-1108
    • Romero, J.R.1    Suzuka, S.M.2    Nagel, R.L.3    Fabry, M.E.4
  • 77
    • 0043204998 scopus 로고    scopus 로고
    • Arginine therapy: A new treatment for pulmonary hypertension in sickle cell disease?
    • Morris CR, Morris SM Jr, Hagar W, et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med. 2003;168(1):63-69.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.1 , pp. 63-69
    • Morris, C.R.1    Morris Jr, S.M.2    Hagar, W.3
  • 78
    • 17844409340 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathies
    • Derchi G, Forni GL, Formisano F, et al. Efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathies. Haematologica. 2005;90(4):452-458.
    • (2005) Haematologica , vol.90 , Issue.4 , pp. 452-458
    • Derchi, G.1    Forni, G.L.2    Formisano, F.3
  • 79
    • 33750473708 scopus 로고    scopus 로고
    • Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism
    • Burnett AL, Bivalacqua TJ, Champion HC, Musicki B. Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. J Sex Med. 2006;3(6):1077-1084.
    • (2006) J Sex Med , vol.3 , Issue.6 , pp. 1077-1084
    • Burnett, A.L.1    Bivalacqua, T.J.2    Champion, H.C.3    Musicki, B.4
  • 80
    • 0037101989 scopus 로고    scopus 로고
    • Sildenafil relieves priapism in patients with sickle cell disease
    • Bialecki ES, Bridges KR. Sildenafil relieves priapism in patients with sickle cell disease. Am J Med. 2002;113(3):252.
    • (2002) Am J Med , vol.113 , Issue.3 , pp. 252
    • Bialecki, E.S.1    Bridges, K.R.2
  • 82
    • 43049145818 scopus 로고    scopus 로고
    • Endothelin receptor antagonism prevents hypoxiainduced mortality and morbidity in a mouse model of sickle-cell disease
    • Sabaa N, de Franceschi L, Bonnin P, et al. Endothelin receptor antagonism prevents hypoxiainduced mortality and morbidity in a mouse model of sickle-cell disease. J Clin Invest. 2008;118(5):1924-1933.
    • (2008) J Clin Invest , vol.118 , Issue.5 , pp. 1924-1933
    • Sabaa, N.1    de Franceschi, L.2    Bonnin, P.3


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