Peptides based on αV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation

American Journal of Physiology - Cell Physiology

Volumn 291, Issue 5, 2006, Pages

  Kaul, Dhananjay K ^a   Liu, Xiao Du ^a   Zhang, Xiaoqin ^a   Mankelow, Tosti ^b   Parsons, Stephen ^b   Spring, Frances ^b   An, Xiuli ^c   Mohandas, Narla ^c   Anstee, David ^b   Chasis, Joel Anne ^d  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c NEW YORK BLOOD CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

V 3 integrin; Endothelium; Erythrocytes; Intercellular adhesion molecule 4; Peripheral resistance unit; Sickle cell disease

Indexed keywords

CD51 ANTIGEN; MEMBRANE PROTEIN; PEPTIDE DERIVATIVE; PROTEIN ATSR; PROTEIN ICAM 4; PROTEIN INHIBITOR; PROTEIN SERINE THREONINE KINASE; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG; CELL ADHESION MOLECULE; PEPTIDE;

ARTICLE; CELL ADHESION; CELL INTERACTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; ERYTHROCYTE; EX VIVO STUDY; FLUORESCENCE MICROSCOPY; HEMODYNAMICS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROCIRCULATION; PRIORITY JOURNAL; PROTEIN BINDING; SHEAR FLOW; SICKLE CELL ANEMIA; VASCULAR DISEASE; VASCULARIZATION; VENULE; ANIMAL; CHEMISTRY; CYTOLOGY; ERYTHROCYTE DISORDER; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; RAT; REGRESSION ANALYSIS;

ANEMIA, SICKLE CELL; ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; ENDOTHELIAL CELLS; ERYTHROCYTES, ABNORMAL; HUMANS; INTEGRIN ALPHAV; MICROCIRCULATION; PEPTIDES; PLATELET ACTIVATING FACTOR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; REGRESSION ANALYSIS;

EID: 33751092291     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00639.2005     Document Type: Article

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