Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 6 57-6, 2005, Pages

  Belcher, John D ^a,b   Mahaseth, Hemchandra ^a   Welch, Thomas E ^a   Vilback, Asa E ^a   Sonbol, Khalid M ^a   Kalambur, Venkatasubramaniam S ^c   Bowlin, Paul R ^a   Bischof, John C ^c   Hebbel, Robert P ^a,b   Vercellotti, Gregory M ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c University of Minnesota   (United States)

Author keywords

Dexamethasone; Intercellular adhesion molecule; Nuclear factor B; Sickle cell anemia; Vascular cell adhesion molecule

Indexed keywords

ALPHA GLOBIN; BETA GLOBULIN; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MONOCLONAL ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL OCCLUSION; CELL ACTIVATION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ERYTHROCYTE; FEMALE; HYPOXIA; LEUKOCYTE; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REOXYGENATION; SICKLE CELL; SKIN; VENULE;

ANEMIA, SICKLE CELL; ANIMALS; ANOXIA; BLOOD FLOW VELOCITY; DEXAMETHASONE; ENDOTHELIUM, VASCULAR; HEART RATE; HEMOGLOBIN, SICKLE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MICE; MICE, TRANSGENIC; NF-KAPPA B; SKIN; VASCULAR CELL ADHESION MOLECULE-1; VENULES;

EID: 21144440415     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00986.2004     Document Type: Article

References (59)

1. Adamides S, Konstantopoulos K, Toumbis M, Douratsos D, Travlou A, and Kasfiki A. A study of β-thromboglobulin and platelet factor-4 plasma levels in steady state sickle cell patients. Blut 61: 245-247, 1990.
2. Aslan M, Ryan TM, Adler B, Townes TM, Parks DA, Thompson JA, Tousson A, Gladwin MT, Patel RP, Tarpey MM, Batinic-Haberle I, White CR, and Freeman BA. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci USA 98: 15215-15220, 2001.
3. Awogu AU. Leucocyte counts in children with sickle cell anaemia usefulness of stable state values during infections. West Afr J Med 19: 55-58, 2000.
4. Aziz KE and Wakefield D. Modulation of endothelial cell expression of ICAM-1, E-selectin, and VCAM-1 by β-estradiol, progesterone, and dexamethasone. Cell Immunol 167: 79-85, 1996.
5. Baatz H, Steinbauer M, Harris AG, and Krombach F. Kinetics of white blood cell staining by intravascular administration of rhodamine 6G. Int J Microcirc Clin Exp 15: 85-91, 1995.
6. Belcher JD, Bryant CJ, Nguyen J, Bowlin PR, Kielbik MC, Bischof JC, Hebbel RP, and Vercellotti GM. Transgenic sickle mice have vascular inflammation. Blood 101: 3953-3959, 2003.
7. Belcher JD, Marker PH, Weber JP, Hebbel RP, and Vercellotti GM. Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion. Blood 96: 2451-2459, 2000.
8. Bernini JC, Rogers ZR, Sandler ES, Reisch JS, Quinn CT, and Buchanan GR. Beneficial effect of intravenous dexamethasone in children with mild to moderately severe acute chest syndrome complicating sickle cell disease. Blood 92: 3082-3089, 1998.
9. Borders JL and Granger HJ. An optical Doppler intravital velocimeter. Microvasc Res 27: 117-127, 1984.
10. Brown MD, Wick TM, and Eckman JR. Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells. Pediatr Pathol Mol Med 20: 47-72, 2001.
11. Bunn HF. Pathogenesis and treatment of sickle cell disease. N Engl J Med 337: 762-769, 1997.
12. 4. J Appl Physiol 94: 2313-2322, 2003.
13. Conran N, Fattori A, Saad ST, and Costa FF. Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea. Am J Hematol 76: 343-347, 2004.
14. Croizat H. Circulating cytokines in sickle cell patients during steady state. Br J Haematol 87: 592-597, 1994.
15. Davis MJ. Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter. Microvasc Res 34: 223-230, 1987.
16. De Bosscher K, Vanden Berghe W, and Haegeman G. The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: molecular mechanisms for gene repression. Endocr Rev 24: 488-522, 2003.
17. Deryckere F and Gannon F. A one-hour minipreparation technique for extraction of DNA-binding proteins from animal tissues. Biotechniques 16: 405, 1994.
18. Embury S, Hebbel R, Steinberg M, and Mohandas N. Pathogenesis of Vasoocclusion. In: Sickle Cell Disease: Basic Principles and Clinical Practice, edited by Embury S, Hebbel R, Mohandas N, and Steinberg M. New York: Raven, 1994, p. 311-326.
19. Embury SH, Matsui NM, Ramanujam S, Mayadas TN, Noguchi CT, Diwan BA, Mohandas N, and Cheung AT. The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood 104: 3378-3385, 2004.
20. Fabry ME, Sengupta A, Suzuka SM, Costantini F, Rubin EM, Hofrichter J, Christoph G, Manci E, Culberson D, and Factor SM. A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity. Blood 86: 2419-2428, 1995.
21. Fadlon E, Vordermeier S, Pearson TC, Mire-Sluis AR, Dumonde DC, Phillips J, Fishlock K, and Brown KA. Blood polymorphonuclear leukocytes from the majority of sickle cell patients in the crisis phase of the disease show enhanced adhesion to vascular endothelium and increased expression of CD64. Blood 91: 266-274, 1998.
22. Faller D. Vascular modulation. In: Sickle Cell Disease: Basic Principles and Clinical Practice, edited by Embury S, Hebbel R, Mohandas N, and Steinberg M. New York: Raven, 1994, p. 235-246.
23. Francis RB Jr and Haywood LJ. Elevated immunoreactive tumor necrosis factor and interleukin-1 in sickle cell disease. J Natl Med Assoc 84: 611-615, 1992.
24. Griffin TC, McIntire D, and Buchanan GR. High-dose intravenous methylprednisolone therapy for pain in children and adolescents with sickle cell disease. N Engl J Med 330: 733-737, 1994.
25. Hofstra TC, Kalra VK, Meiselman HJ, and Coates TD. Sickle erythrocytes adhere to polymorphonuclear neutrophils and activate the neutrophil respiratory burst. Blood 87: 4440-4447, 1996.
26. Hogan RD, Morris RF, and McMurray SK. A digital video image splitting device for microvascular measurements. Microvasc Res 27: 128-132, 1984.
27. Hong JH, Chiang CS, Tsao CY, Lin PY, Wu CJ, and McBride WH. Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses? Int J Radiat Oncol Biol Phys 51: 296-303, 2001.
28. Ito A, Miyake M, Morishita M, Ito K, Torii S, and Sakamoto T. Dexamethasone reduces lung eosinophilia, and VCAM-1 and ICAM-1 expression induced by Sephadex beads in rats. Eur J Pharmacol 468: 59-66, 2003.
29. Kalambur VS, Mahaseth H, Bischof JC, Kielbik MC, Welch TE, Vilback A, Swanlund DJ, Hebbel RP, Belcher JD, and Vercellotti GM. Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy. Am J Hematol 77: 117-125, 2004.
30. Karin M and Chang L. AP-1-glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol 169: 447-451, 2001.
31. Kaul DK and Hebbel RP. Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice. J Clin Invest 106: 411-420, 2000.
32. Kaul DK, Liu XD, Choong S, Belcher JD, Vercellotti GM, and Hebbel RP. Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice. Am J Physiol Heart Circ Physiol 287: H293-H301, 2004.
33. Lard LR, Mul FP, de Haas M, Roos D, and Duits AJ. Neutrophil activation in sickle cell disease. J Leukoc Biol 66: 411-415, 1999.
34. Malave I, Perdomo Y, Escalona E, Rodriguez E, Anchustegui M, Malave H, and Arends T. Levels of tumor necrosis factor α/cachectin (TNFα) in sera from patients with sickle cell disease. Acta Haematol 90: 172-176, 1993.
35. Matsui NM, Borsig L, Rosen SD, Yaghmai M, Varki A, and Embury SH. P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood 98: 1955-1962, 2001.
36. McKay LI and Cidlowski JA. Cross-talk between nuclear factor-κB and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol 12: 45-56, 1998.
37. Mori N, Horie Y, Gerritsen ME, Anderson DC, and Granger DN. Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds. Gut 44: 186-195, 1999.
38. Osarogiagbon UR, Choong S, Belcher JD, Vercellotti GM, Paller MS, and Hebbel RP. Reperfusion injury pathophysiology in sickle transgenic mice. Blood 96: 314-320, 2000.
39. Papadimitriou CA, Travlou A, Kalos A, Douratsos D, and Lali P. Study of platelet function in patients with sickle cell anemia during steady state and vaso-occlusive crisis. Acta Haematol 89: 180-183, 1993.
40. Pauling L, Itano HA, and Singer SJ. Sickle cell anemia, a molecular disease. Science 100: 543-548, 1949.
41. Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, and Stern DM. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest 97: 493-500, 1996.
42. Pritchard KA Jr, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, and Hillery CA. Hypoxia-induced acute lung injury in murine models of sickle cell disease. Am J Physiol Lung Cell Mol Physiol 286: L705-L714, 2004.
43. Setty BN and Stuart MJ. Vascular cell adhesion molecule-1 is involved in mediating hypoxia-induced sickle red blood cell adherence to endothelium: potential role in sickle cell disease. Blood 88: 2311-2320, 1996.
44. Smolinski PA, Offermann MK, Eckman JR, and Wick TM. Double-stranded RNA induces sickle erythrocyte adherence to endothelium: a potential role for viral infection in vaso-occlusive pain episodes in sickle cell anemia. Blood 85: 2945-2950, 1995.
45. Solovey A, Lin Y, Browne P, Choong S, Wayner E, and Hebbel RP. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med 337: 1584-1590, 1997.
46. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314, 1994.
47. Sultana C, Shen Y, Rattan V, Johnson C, and Kalra VK. Interaction of sickle erythrocytes with endothelial cells in the presence of endothelial cell conditioned medium induces oxidant stress leading to transendothelial migration of monocytes. Blood 92: 3924-3935, 1998.
48. Takano M, Meneshian A, Sheikh E, Yamakawa Y, Wilkins KB, Hopkins EA, and Bulkley GB. Rapid upregulation of endothelial P-selectin expression via reactive oxygen species generation. Am J Physiol Heart Circ Physiol 283: H2054-H2061, 2002.
49. Terada LS. Oxidative stress and endothelial activation. Crit Care Med 30: S186-S191, 2002.
50. Turhan A, Jenab P, Bruhns P, Ravetch JV, Coller BS, and Frenette PS. Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes. Blood 103: 2397-2400, 2004.
51. Turhan A, Weiss LA, Mohandas N, Coller BS, and Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci USA 99: 3047-3051, 2002.
52. Van Oosten M, van de Bilt E, de Vries HE, van Berkel TJ, and Kuiper J. Vascular adhesion molecule-1 and intercellular adhesion molecule-1 expression on rat liver cells after lipopolysaccharide administration in vivo. Hepatology 22: 1538-1546, 1995.
53. Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, and Nickerson B. Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease. Blood 89: 1787-1792, 1997.
54. Watanabe M. [Expression of adhesion molecules in transplanted lung allografts - immunohistochemical study using the rat lung transplantation model.] Hokkaido Igaku Zasshi 69: 718-729, 1994.
55. West MS, Wethers D, Smith J, and Steinberg M. Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease. J Clin Epidemiol 45: 893-909, 1992.
56. Westwick J, Watson-Williams EJ, Krishnamurthi S, Marks G, Ellis V, Scully MF, White JM, and Kakkar VV. Platelet activation during steady state sickle cell disease. J Med 14: 17-36, 1983.
57. Wood JG, Johnson JS, Mattioli LF, and Gonzalez NC. Systemic hypoxia increases leukocyte emigration and vascular permeability in conscious rats. J Appl Physiol 89: 1561-1568, 2000.
58. Wood JG, Mattioli LF, and Gonzalez NC. Hypoxia causes leukocyte adherence to mesenteric venules in nonacclimatized, but not in acclimatized, rats. J Appl Physiol 87: 873-881, 1999.
59. Wun T, Cordoba M, Rangaswami A, Cheung AW, and Paglieroni T. Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease. Clin Lab Haematol 24: 81-88, 2002.