Implication of the JNK pathway in a rat model of Huntington's disease

Experimental Neurology

Volumn 215, Issue 1, 2009, Pages 191-200

  Perrin, V ^a   Dufour, N ^b,c   Raoul, C ^a   Hassig, R ^b,c   Brouillet, E ^b,c   Aebischer, P ^a   Luthi Carter, R ^a   Deglon N ^b,c  

^a EPFL   (Switzerland)

^b SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; LENTIVIRUS VECTOR; PHOSPHOPROTEIN DARPP 32; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE MODEL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; CELL LINE, TRANSFORMED; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HUNTINGTON DISEASE; LENTIVIRUS; MAP KINASE KINASE 4; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, WISTAR; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 57449085907     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.10.008     Document Type: Article

References (41)

1. Barr R.K., Kendrick T.S., and Bogoyevitch M.A. Identification of the critical features of a small peptide inhibitor of JNK activity. J. Biol. Chem. 277 (2002) 10987-10997
2. Behrens A., Sibilia M., and Wagner E.F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21 (1999) 326-329
3. Bensadoun J.C., de Almeida L.P., Dreano M., Aebischer P., and Deglon N. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Eur. J. Neurosci. 14 (2001) 1753-1761
4. Bogoyevitch M.A., and Kobe B. Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases. Microbiol. Mol. Biol. Rev. 70 (2006) 1061-1095
5. Bonny C., Nicod P., and Waeber G. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. J. Biol. Chem. 273 (1998) 1843-1846
6. Borsello T., Clarke P.G., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., Bonny C., Oberson A., Negri S., and Sauser C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Nat. Med. 9 (2003) 1180-1186
7. Borsello T., Croquelois K., Hornung J.P., and Clarke P.G. N-methyl-d-aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway. Eur. J. Neurosci. 18 (2003) 473-485
8. Bozyczko-Coyne D., Saporito M.S., and Hudkins R.L. Targeting the JNK pathway for therapeutic benefit in CNS disease. Curr. Drug Targets CNS Neurol. Disord. 1 (2002) 31-49
9. Davis R.J. MAPKs: new JNK expands the group. Trends Biochem. Sci. 19 (1994) 470-473
10. de Almeida L.P., Ross C.A., Zala D., Aebischer P., and Deglon N. Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. J. Neurosci. 22 (2002) 3473-3483
11. Deglon N., Tseng J.L., Bensadoun J.C., Zurn A.D., Arsenijevic Y., Pereira de Almeida L., Zufferey R., Trono D., and Aebischer P. Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum. Gene. Ther. 11 (2000) 179-190
12. Dickens M., Rogers J.S., Cavanagh J., Raitano A., Xia Z., Halpern J.R., Greenberg M.E., Sawyers C.L., and Davis R.J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277 (1997) 693-696
13. Einhauer A., and Jungbauer A. The FLAG peptide, a versatile fusion tag for the purification of recombinant proteins. J. Biochem. Biophys. Methods 49 (2001) 455-465
14. Garcia M., Vanhoutte P., Pages C., Besson M.J., Brouillet E., and Caboche J. The mitochondrial toxin 3-nitropropionic acid induces striatal neurodegeneration via a c-Jun N-terminal kinase/c-Jun module. J. Neurosci. 22 (2002) 2174-2184
15. Garcia M., Charvin D., and Caboche J. Expanded huntingtin activates the c-Jun N terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture. Neuroscience 127 (2004) 859-870
16. Huntington's disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
17. Ham J., Babij C., Whitfield J., Pfarr C.M., Lallemand D., Yaniv M., and Rubin L.L. A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14 (1995) 927-939
18. Hibi M., Lin A., Smeal T., Minden A., and Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes. Dev. 7 (1993) 2135-2148
19. Hottinger A.F., Azzouz M., Deglon N., Aebischer P., and Zurn A.D. Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus. J. Neurosci. 20 (2000) 5587-5593
20. Liu Y.F. Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line. J. Biol. Chem. 273 (1998) 28873-28877
21. Liu Y.F., Dorow D., and Marshall J. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. J. Biol. Chem. 275 (2000) 19035-19040
22. Lunkes A., Lindenberg K.S., Ben-Haiem L., Weber C., Devys D., Landwehrmeyer G.B., Mandel J.L., and Trottier Y. Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions. Mol. Cell. 10 (2002) 259-269
23. Merienne K., Helmlinger D., Perkin G.R., Devys D., and Trottier Y. Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway. J. Biol. Chem. 278 (2003) 16957-16967
24. Meriin A.B., Mabuchi K., Gabai V.L., Yaglom J.A., Kazantsev A., and Sherman M.Y. Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J. Cell. Biol. 153 (2001) 851-864
25. Mooser V., Maillard A., Bonny C., Steinmann M., Shaw P., Yarnall D.P., Burns D.K., Schorderet D.F., Nicod P., and Waeber G. Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 55 (1999) 202-208
26. Ogata M., Hino S., Saito A., Morikawa K., Kondo S., Kanemoto S., Murakami T., Taniguchi M., Tanii I., Yoshinaga K., Shiosaka S., Hammarback J.A., Urano F., and Imaizumi K. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 26 (2006) 9220-9231
27. Pulverer B.J., Kyriakis J.M., Avruch J., Nikolakaki E., and Woodgett J.R. Phosphorylation of c-jun mediated by MAP kinases. Nature 353 (1991) 670-674
28. Raoul C., Estevez A.G., Nishimune H., Cleveland D.W., deLapeyriere O., Henderson C.E., Haase G., and Pettmann B. Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations. Neuron 35 (2002) 1067-1083
29. Regulier E., Pereira de Almeida L., Sommer B., Aebischer P., and Deglon N. Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease. Hum. Gene. Ther. 13 (2002) 1981-1990
30. Resnick L., and Fennell M. Targeting JNK3 for the treatment of neurodegenerative disorders. Drug Discov. Today. 9 (2004) 932-939
31. Robinson M.J., and Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell. Biol. 9 (1997) 180-186
32. Schwarzschild M.A., Cole R.L., and Hyman S.E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17 (1997) 3455-3466
33. Sherman M.Y., and Goldberg A.L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29 (2001) 15-32
34. Takeda K., Matsuzawa A., Nishitoh H., and Ichijo H. Roles of MAPKKK ASK1 in stress-induced cell death. Cell. Struct. Funct. 28 (2003) 23-29
35. Tammariello S.P., Landreth G.E., and Estus S. The role of Jun kinase in apoptosis. In: Mattson M.P., Estus S., and Rangnekar V.M. (Eds). Role in Disease, Pathogenesis and Prevention (2001), Elsevier Science 197-214
36. Vonsattel J.P., and DiFiglia M. Huntington disease. J. Neuropathol. Exp. Neurol. 57 (1998) 369-384
37. Whitfield J., Neame S.J., Paquet L., Bernard O., and Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29 (2001) 629-643
38. Whitmarsh A.J., and Davis R.J. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem. Sci. 23 (1998) 481-485
39. Whitmarsh A.J., Cavanagh J., Tournier C., Yasuda J., and Davis R.J. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281 (1998) 1671-1674
40. Xu S., Robbins D.J., Christerson L.B., English J.M., Vanderbilt C.A., and Cobb M.H. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 5291-5295
41. Yang D.D., Kuan C.Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., and Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 (1997) 865-870