Oxidative stress mediated idiosyncratic drug toxicity

Drug Metabolism Reviews

Volumn 37, Issue 2, 2005, Pages 311-325

  Tafazoli, Shahrzad ^a   Spehar, Dane D ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

ADMET; Cooxidation; Idiosyncratic drug toxicity; Oxidative stress; Prooxidant

Indexed keywords

CYTOCHROME P450; DICLOFENAC; ENTACAPONE; HYDROGEN PEROXIDE; MEFENAMIC ACID; MYELOPEROXIDASE; PEROXIDASE; PHENYLBUTAZONE; PROSTAGLANDIN SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLCAPONE; TROGLITAZONE; XENOBIOTIC AGENT;

ANIMAL CELL; BINDING AFFINITY; CARCINOGENESIS; CATALYSIS; CELL ISOLATION; CONFERENCE PAPER; COVALENT BOND; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG SCREENING; DRUG WITHDRAWAL; ENZYME ACTIVATION; GASTROINTESTINAL TOXICITY; KUPFFER CELL; LIPID OXIDATION; LIPID PEROXIDATION; LIVER CELL; LIVER TOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RAT;

ANIMALS; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; GLUTATHIONE; HEPATITIS, TOXIC; HEPATOCYTES; INFLAMMATION; LIPID PEROXIDATION; MODELS, BIOLOGICAL; NAD; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHARMACEUTICAL PREPARATIONS; RATS;

EID: 18744364709     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-200055227     Document Type: Conference Paper

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