An in vitro study on methotrexate hydroxylation in rat and human liver

Physiological Research

Volumn 46, Issue 5, 1997, Pages 371-379

  Chladek J ^a   Martinkova J ^a   Sispera L ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

7 hydroxymethotrexate; Allopurinol; Cytochrome P450; In vitro inhibition; Menadion; Methotrexate; Rat and human liver

Indexed keywords

7 HYDROXYMETHOTREXATE; ALDEHYDE OXIDASE; ALLOPURINOL; BETA NAPHTHOFLAVONE; CYTOCHROME P450; DEXAMETHASONE; ETHOXYCOUMARIN; ETHOXYRESORUFIN; MENADIONE; METHOTREXATE; PENTOXYRESORUFIN; PHENOBARBITAL; XANTHINE OXIDASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; FOLIC ACID ANTAGONISTS; HUMANS; HYDROXYLATION; MALE; METHOTREXATE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

EID: 0030817853     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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