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Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRPS) gene: Are they a risk factor in osteoarthritis?
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Smith AJ, Gidley J, Sandy JR, et al.: Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRPS) gene: are they a risk factor in osteoarthritis? Osteoarthritis Cartilage 2005, 13:608-613. Since we now believe that bone tissue is a key factor in the onset of osteoarthritis, this study illustrates that bone-specific genes are altered in osteoarthritic bone tissue. Hence, the LRP5 gene may be a potential target for future research on the cause of osteoarthritis through the bone hypothesis. The paper also offers other potential key target bone genes involved in the disease.
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Osteoarthritis Cartilage
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Smith, A.J.1
Gidley, J.2
Sandy, J.R.3
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50
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Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees
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Raynauld JP, Kauffmann C, Beaudoin G, et al.: Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees. Osteoarthritis Cartilage 2003, 11:351-360.
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Raynauld, J.P.1
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Beaudoin, G.3
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Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes
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Raynauld JP, Martel-Pelletier J, Berthiaume MJ, et al.: Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes. Arthritis Rheum 2004, 50:476-487. This is the first longitudinal study in a large cohort of knee osteoarthritic patients that provides major insight into the predominant risk factors associated with disease progression.
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Arthritis Rheum
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Raynauld, J.P.1
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