Nonviral delivery of siRNA into mesenchymal stem cells by a combination of ultrasound and microbubbles

Journal of Controlled Release

Volumn 133, Issue 2, 2009, Pages 146-153

  Otani, Kentaro ^a,b   Yamahara, Kenichi ^a   Ohnishi, Shunsuke ^a   Obata, Hiroaki ^a   Kitamura, Soichiro ^a   Nagaya, Noritoshi ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b Japan Health Sciences Foundation   (Japan)

Author keywords

Drug delivery system; Microbubbles; siRNA; Stem cell; Ultrasound

Indexed keywords

ACOUSTIC WAVES; CELLS; CODES (SYMBOLS); DRUG DELIVERY; FLOWCHARTING; NUCLEIC ACIDS; RNA; TRANSPLANTATION (SURGICAL); ULTRASONICS;

DRUG DELIVERY SYSTEM; MICROBUBBLES; SIRNA; STEM CELL; ULTRASOUND;

CELL CULTURE;

FLUORESCENT DYE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FEASIBILITY STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROBUBBLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ULTRASOUND;

ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL SURVIVAL; CELLS, CULTURED; FERRIC COMPOUNDS; GENE EXPRESSION; INSULIN; IRON; MALE; MESENCHYMAL STEM CELLS; MICROBUBBLES; OXIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION; ULTRASONICS;

EID: 57349146702     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.088     Document Type: Article

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