Viral gene delivery of superoxide dismutase attenuates experimental cholestasis-induced liver fibrosis in the rat

Gene Therapy

Volumn 9, Issue 3, 2002, Pages 183-191

  Zhong, Z ^a   Froh, M ^a   Wheeler, M D ^a   Smutney, O ^a   Lehmann, T G ^a   Thurman, R G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Bile duct ligation; Fibrosis; Lipid peroxidation; TGF ; TNF

Indexed keywords

4 HYDROXYNONENAL; ALANINE AMINOTRANSFERASE; BETA GALACTOSIDASE; BILE ACID; COLLAGEN TYPE 1; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; OXYGEN RADICAL; PENTOBARBITAL; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; CHOLESTASIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; ENZYME ACTIVITY; GENE TARGETING; HYDROPHOBICITY; LIPID PEROXIDATION; LIVER FIBROSIS; LIVER INJURY; LIVER NECROSIS; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALIA; BACTERIA (MICROORGANISMS);

ANIMALS; CHOLESTASIS, INTRAHEPATIC; COLLAGEN TYPE I; FIBROSIS; GENE THERAPY; GENETIC VECTORS; LIPID PEROXIDATION; LIVER; MALE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036190844     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301638     Document Type: Article

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