Synthesis and antimalarial activity of novel side chain modified antimalarial agents derived from 4-aminoquinoline

Medicinal Chemistry

Volumn 4, Issue 5, 2008, Pages 446-456

  Solomon, V Raja ^a   Haq, W ^a   Smilkstein, M ^b   Srivastava, Kumkum ^a   Rajakumar, S ^a   Puri, Sunil K ^a   Katti, S B ^a   Katti, Setu B ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

4 aminoquinoline; Amino acid conjugates; Antimalarial agents

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; [2 (7 CHLOROQUINOLIN 4 YLAMINO)ETHYL]LYSYLAMIDE; [2 (7 CHLOROQUINOLIN 4 YLAMINO)ETHYL]ORNITHYLAMIDE; [3 (7 CHLOROQUINOLIN 4 YLAMINO)PROPYL]LYSYLAMIDE; [3 (7 CHLOROQUINOLIN 4 YLAMINO)PROPYL]ORNITHYLAMIDE; [4 (7 CHLOROQUINOLIN 4 YLAMINO)BUTYL]LYSYLAMIDE; [4 (7 CHLOROQUINOLIN 4 YLAMINO)BUTYL]ORNITHYLAMIDE; [5 (7 CHLOROQUINOLIN 4 YLAMINO)PENTYL]LYSYLAMIDE; [5 (7 CHLOROQUINOLIN 4 YLAMINO)PENTYL]ORNITHYLAMIDE; ANTIMALARIAL AGENT; CHLOROQUINE; LYSINE; ORNITHINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; MALARIA; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; CHLOROQUINE; DRUG RESISTANCE, MULTIPLE; INHIBITORY CONCENTRATION 50; LYSINE; ORNITHINE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57349131798     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340608785700207     Document Type: Article

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