Perspective on the genetics of attention deficit/hyperactivity disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 8, 2008, Pages 1334-1336

  Neale, Benjamin M ^a,b,c,d   Faraone, Stephen V ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENTION DEFICIT DISORDER; CONDUCT DISORDER; EDITORIAL; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; INHERITANCE; MINIMAL RESIDUAL DISEASE; PRIORITY JOURNAL;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE (GENETICS);

EID: 57349106667     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30875     Document Type: Editorial

References (37)

1. Altshuler D, Daly M. 2007. Guilt beyond a reasonable doubt. Nat Genet 39:813-815.
2. Anney R, Kenny E, Ó'Dúshláine C, Lasky-Su J, Franke B, Morris D, Neale B, Asherson P, Faraone S, Gill M. 2008. Non-random error in genotype calling procedures: Implications for family-based and case-control genome-wide association studies. Am J Med Genet Part B (in press).
3. Biederman J, Faraone SV. 2005. Attention deficit hyperactivity disorder. Lancet 366:237-248.
4. Cheuk DK, Wong V. 2006. Meta-analysis of association between a catechol-o-methyltransferase gene polymorphism and attention deficit hyperactivity disorder. Behav Genet 36(5):651-659.
5. Colhoun HM, McKeigue PM, Davey Smith G. 2003. Problems of reporting genetic associations with complex outcomes. Lancet 361:865-872.
6. Doyle A, Ferreira M, Sklar P, Lasky-Su J, Petty C, Fusillo S, Seidman L, Willcutt E, Smoller J, Pucell S, Biederman J, Faraone S. (In Press) Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: Suggestive linkage to 3q13. Neuropsychiatric Genet.
7. Dudbridge F, Gusnanto A. 2008. Estimation of significance thresholds for genomewide association scans. Genet Epidemiol 32:227-234.
8. Faraone SV, Sergeant J, Gillberg C, Biederman J. 2003. The worldwide prevalence of ADHD: Is it an American condition? World Psychiatry 2:104-113.
9. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick J, Holmgren MA, Sklar P. 2005. Molecular genetics of attention deficit hyperactivity disorder. Biol Psychiatry 57:1313-1323.
10. Faraone SV, Biederman J, Spencer TJ, Aleardi M. 2006. Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med 8:4.
11. Faraone SV, Doyle AE, Lasky-Su J, Sklar PB, D'Angelo E, Gonzalez-Heydrich J, Kratochvil C, Mick E, Klein K, Rezac AJ, Biederman J. 2008. Linkage analysis of attention deficit hyperactivity disorder (p n/a).
12. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, et al. 2008. Collaborative genomewide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet.
13. Gjone H, Stevenson J, Sundet J. 1996. Genetic influence on parent-reported attention-related problems in a Norwegian general population twin sample. J Am Acad Child Adolesc Psychiatry 35:588-598.
14. Hirschhorn JN, Altshuler D. 2002. Once and again-issues surrounding replication in genetic association studies. J Clin Endocrinol Metab 87:4438-4441.
15. Lasky-Su J, Neale B, Franke B, Anney R, Zhou K, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Rothenberger A, Sergeant J, Songua-Barke E, Steinhausen HC, Taylor E, Daly M, Laird NM, Lange C, Faraone SV. 2008. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet Part B (in press).
16. Lasky-Su J, Anney R, Neale B, Franke B, Zhou K, Maller J, Arias-Vásquez A, et al. (In Press) Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. Neuropsychiatric Genetics.
17. Levy F, Hay D, McStephen M, Wood C, Waldman I. 1997. Attention-deficit hyperactivity disorder: A category or a continuum? Genetic analysis of a large-scale twin study. J Am Acad Child Adolesc Psychiatry 36:737-744.
18. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. 2003. Metaanalysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182.
19. Mick E, Faraone SV. 2008. Genetics of attention deficit hyperactivity disorder. Child Adolesc Psychiatr Clin N Am 17:261-284. vii-viii.
20. Mick E, Neale B, Middleton F, McGough J, Faraone SV. 2008. Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Am J Med Genet Part B (in press).
21. Munafo MR, Clark TG, Flint J. 2004. Assessing publication bias in genetic association studies: Evidence from a recent meta-analysis. Psychiatry Res 129:39-44.
22. Neale BM, Sham PC. 2004. The future of association studies: Gene-based analysis and replication. Am J Hum Genet 75:353-362.
23. Neale B, Lasky-Su J, Anney R, Franke B, Zhou K, Maller J, Arias-Vásquez A., et al. 2008. Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet Part B (in press).
24. Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, Fisher SA, Roberts RG, et al. 2007. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39:830-832.
25. Pe'er I, Yelensky R, Altshuler D, Daly MJ. 2008. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 32:381-385.
26. Redden DT, Allison DB. 2003. Nonreplication in genetic association studies of obesity and diabetes research. J Nutr 133:3323-3326.
27. Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR. 2007. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 39:596-604.
28. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, et al. 2007. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316(5829):1331-1336.
29. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, et al. 2007. A Genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants. Science 316(5829):1341-1345.
30. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P. 2007. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445:881-885.
31. Sonuga-Barke E, Lasky-Su J, Neale B, Oades RD, Chen W, Franke B, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Anney R, Miranda A, Mulas F, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Asherson P, Faraone SV. 2008. Novel genes and gene x environment interactions for attention deficit/hyperactivity disorder and comorbid conduct disorder revealed in a genome wide association scan. Am J Med Genet Part B (in press).
32. Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, et al. 2007. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39(6):770-775.
33. Vansteelandt S, Demeo DL, Lasky-Su J, Smoller JW, Murphy AJ, McQueen M, Schneiter K, Celedon JC, Weiss ST, Silverman EK, Lange C. 2008. Testing and estimating gene-environment interactions in family-based association studies. Biometrics 64:458-467.
34. Willcutt EG, Pennington BF, DeFries JC. 2000. Etiology of inattention and hyperactivity/impulsivity in a community sample of twins with learning difficulties. J Abnorm Child Psychol 28:149-159.
35. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ., et al. 2007. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341.
36. Zhou K, Dempfle A, Arcos-Burgos M, Bakker S, Banaschewski T, Biederman J, Buitelaar J, et al. (In Press) Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. Neuropsychiatric Genetics.
37. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 147B:1337-1344 (2008)