A molecular guidance system based upon target genes, nuclear receptors and ligands applied to drug discovery and prediction of toxicity

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 12, 2008, Pages 1252-1264

  Mahesh, Virendra B ^a   Sidell, Neil ^b   Ewing, Douglas E ^c   Bransome Jr , Edwin D ^c   Hendry, Lawrence B ^c  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Accelerated Pharmaceuticals Inc   (United States)

Author keywords

Computer modeling; DNA unwinding; Drug design; Hormone response elements; Intercalators; Nuclear receptors; Steroid hormones; Transcription

Indexed keywords

AFLATOXIN; ALDOSTERONE; ALITRETINOIN; ANDROGEN RECEPTOR; BENZO[A]PYRENE; CALCITRIOL; CARCINOGEN; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; ECDYSONE; ECDYSONE RECEPTOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FARNESOID X RECEPTOR; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LIOTHYRONINE; MINERALOCORTICOID RECEPTOR; NEW DRUG; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROGESTERONE; PROGESTERONE RECEPTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TESTOSTERONE; THYROID HORMONE RECEPTOR; VITAMIN D RECEPTOR;

ARTICLE; CHEMICAL STRUCTURE; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG RESEARCH; GENE TARGETING; GENOTOXICITY; HORMONE RESPONSIVE ELEMENT; HUMAN; MOLECULAR GENETICS; PREDICTION; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; X RAY CRYSTALLOGRAPHY;

CELL NUCLEUS; CHEMISTRY, PHARMACEUTICAL; DNA; DRUG DISCOVERY; ESTRADIOL; HORMONES; HUMANS; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RESPONSE ELEMENTS; SOFTWARE; STEROIDS;

EID: 57149140624     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708786140972     Document Type: Article

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