Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor α-1 orphan receptor

Cancer Research

Volumn 59, Issue 18, 1999, Pages 4519-4524

  Yang, Chun ^a   Chen, Shiuan ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CAMPHECLOR; CELL NUCLEUS RECEPTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; CHLORDANE; ESTROGEN RECEPTOR; HYBRID PROTEIN; ORGANOCHLORINE PESTICIDE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; ENDOCRINE FUNCTION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN INTERACTION; YEAST;

BETA-GALACTOSIDASE; BREAST NEOPLASMS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CHLORDAN; CLONING, MOLECULAR; FEMALE; HUMANS; INSECTICIDES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; TOXAPHENE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033567916     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Giguere, V., Yang, N., Segui, S., and Even, R. M. Identification of a new class of steroid hormone receptors. Nature (Lond.) 331: 91-94, 1988.
2. Yang, N., Shigeta, H., Shi, H., and Teng, C. T. Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J. Biol. Chem., 277: 5795-5804, 1996.
3. Shi, H., Shigeta, H., Yang, N., Fu, K., O'Brian, G., and Teng, C. T. Human estrogen receptor-like 1 (ESRL1) gene: genomic organization, chromosomal localization, and promoter characterization. Genomics, 44: 52-60, 1997.
4. Bonnelye, E., Vanacker, J. M., Spruyt, N., Alric, S., Fournier, B., Desbiens, X., and Laudet, V. Expression of the estrogen-rclated receptor 1 (ERR-1) orphan receptor during mouse development. Mech. Dev., 65: 71-85, 1997.
5. Sladek, R., Bader, J. A., and Giguere, V. The orphan nuclear receptor estrogen-related receptor α is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol. Cell. Biol., 17: 5400-5409, 1997.
6. Bonnelye, E., Vanacker, J. M., Dittmar, T., Begue, A., Desbiens, X., Denhardt, D. T., Aubin, J. E., Laudet, V., and Fournier, B. The ERR-1 orphan receptor is a transcriptional activator expressed during bone development. Mol. Endocrinol., 11: 905-916, 1997.
7. Yang, C., Zhou, D., and Chen, S. Modulation of aromatase expression in the breast tissue by ERRaI orphan receptor. Cancer Res., 58: 5695-5700, 1998.
8. Johnston, S., Liu, X., Zuo, F., Eisenbraun, T. L., Wiley, S. R., Kraus, R. J., and Mertz, J. E. Estrogen-related receptor α1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol. Endocrinol., 11: 342-352, 1997.
9. Zhou, D., and Chen, S. Characterization of a silencer element in the human aromatase gene. Arch. Biochem. Biophys., 353: 213-220, 1998.
10. Hong, H., Kohli, K., Trivedi, A., Johnson, D. L., and Stallcup, M. R. GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domain of steroid receptors. Proc. Natl. Acad. Sci. USA, 93: 4948-4952, 1996.
11. Rosenthal, N. Identification of regulatory element of cloned genes with functional assays. Methods Enzymol., 152: 705-720, 1987.
12. Seed, B., and Sheen, J. Y. A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene, 67: 271-277, 1998.
13. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254, 1996.
14. Zhou, D., Pompon, D., and Chen, S. Stable expression of human aromatase cDNA in mammalian cells: a useful system for aromatase inhibitor screening. Cancer Res., 50: 6949-6954, 1990.
15. Ramamoorthy, K., Wang, F., Chen, I-C., Norris, J. D., McDonnell, D. P., Leonard, L. S., Gaido, K. W., Bocchinfuso, W. P., Korach, K. S., and Safe, S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Encocrinology, 138: 1520-1527, 1997.
16. Hong, H., Kohli, K., Garabedian, M. J., and Stallcup, M. R. GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell. Biol., 17: 2735-2744, 1997.
17. Zhou, C., Zhou, D., Esteban, J., Murai, J., Sitteri, P. I., Wilczynski, S., and Chen, S. Aromatase gene expression and its exon I usage in human breast tumors. Detection of aromatase messenger RNA by reverse transcription-polymerase chain reaction (RTPCR). J. Steroid Biochem. Mol. Biol., 59: 163-171, 1996.
18. Forrman, B. M., Tzameli, I., Chois, H.-S., Chen, J., Simha, D., Seol, W., Evans, R. M., and Moore. D. D. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β. Nature (Lond.), 395: 612-615, 1998.
19. Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B. Identification of a nuclear receptor for bile acids. Science (Washington DC), 284: 1362-1365, 1999.
20. Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., and Lehmann, J. M. Bile acids: natural ligands for an orphan nuclear receptor. Science (Washington DC), 284: 1365-1368, 1999.
21. Gustafsson, J-Å. Seeking ligands for lonely orphan receptors. Science (Washington DC), 284: 1285-1286, 1999.
22. Vanacker, J-M., Bonnelye, E., Chopin-Delannoy, S., Delmarre, C., Cavailles, V., and Laudet, V. Transcriptional activities of the orphan nuclear receptor ERRα (estrogen receptor-related receptor-α). Mol. Endocrinol., 13: 764-773, 1999.
23. Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., and Greene, G. L. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell, 95: 927-937, 1998.
24. Bonefeld Jorgensen, E. C., Autrup, H., and Hansen, J. C. Effect of toxaphene on estrogen receptor functions in human breast cancer cells. Carcinogenesis (Lond.), 18: 1651-1654, 1997.
25. Fisher, B. E. Most unwanted: persistent organic pollutants. Environ. Health Perspect., 107: A18-A23, 1999.
26. Johansson, M., Nilsson, S., and Lund, B-O. Interactions between methylsulfonyl PCBs and the glucocorticoid receptor. Environ. Health Perspect., 106: 769-772, 1998.
27. Kao, Y-C., Zhou, C., Sherman, M., Laughton, C. A., and Chen, S. Molecular basis of the inhibition of human aromatase by flavone and isoflavone phytoestrogens. A site-directed mutagenesis study. Environ. Health Perspect., 106: 85-92, 1998.
28. Klinge, C. M., Silver, B. F., Driscoll, M. D., Sathya, G., Bambara, R. A., and Hilf, R. Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half sites, and inhibits estrogen-induced gene expression. J. Biol. Chem., 272: 31465-31474, 1997.