Inhibition of estrogen-dependent breast cell responses with phenylacetate

International Journal of Cancer

Volumn 93, Issue 5, 2001, Pages 687-692

  Sawatsri, Sayan ^a,c   Samid, Dvorit ^b   Malkapuram, Srividya ^a   Sidell, Neil ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c PRAMONGKUTKLAO HOSPITAL   (Thailand)

Author keywords

Breast cancer; Estrogen; Phenylacetate; Receptor

Indexed keywords

4 CHLOROPHENYLACETIC ACID; ANTIESTROGEN; CYCLIN D1; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; LUCIFERASE; PHENYLACETIC ACID; PHENYLACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL DIVISION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG SCREENING ASSAYS, ANTITUMOR; ESTROGENS; GENE EXPRESSION; HUMANS; PHENYLACETATES; PROMOTER REGIONS (GENETICS); TUMOR CELLS, CULTURED;

EID: 0035452346     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1399     Document Type: Article

References (36)

1. Breast cancer
2. Parity, age at first and last birth, and risk of breast cancer: A population-based study in Sweden
3. Antiestrogen-estrogen receptor interactions
4. Editorial: When tamoxifen turns bad
5. Identification of phenylacetic acid as a natural auxin in the shoots of higher plants
6. Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis
7. Waste nitrogen excretion via amino acid acylation: Benzoate and phenylacetate in lysinuric protein intolerance
8. Treatment of urea cycle disorders
9. Maternal phenylketonuria and hyperphenylalaninemia: An international survey of outcome of untreated and treated pregnancies
10. Phenylacetate: A novel nontoxic inducer of tumor cell differentiation
11. Selective activity of phenylacetate against malignant gliomas: Resemblance to fetal brain damage in phenylketonuria
12. Phenylacetate synergizes with retinoic acid in inducing the differentiation of human neuroblastoma cells
13. Cytostatic activity of phenylacetate and derivatives against tumor: Correlation with lipophilicity and inhibition of protein prenylation
14. Phenylacetic acid halides inhibit estrogen receptor (ER)-positive MCF-7 cells, but not ER-negative human breast cancer cells or normal breast epithelial cells
15. Sodium phenylacetate induces growth inhibition and bcl-2 downregulation and apoptosis in MCF7ras cells in vitro and in nude mice
16. Downregulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol
17. Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line
18. Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor
19. Changes in estrogen receptor messenger ribonucleic acid in sheep fetal and maternal tissues during late gestation and labor
20. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb-A
21. A pure antiestrogen, ICI 182,780, stimulates the growth of tamoxifen-resistant KPL-1 human breast cancer cells in vivo but not in vitro
22. Expression and regulation of cyclin genes in breast cancer
23. Mammalian G1 cyclins
24. Transcriptional upregulation of retinoic acid receptor β (RARβ) expression by phenylacetate in human neuroblastoma cells
25. Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: Evidence for multiple inhibitory pathways
26. A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer
27. Tumor growth inhibition, apoptosis, and Bcl-2 downregulation of MCF-7ras tumors by sodium phenylacetate and tamoxifen combination
28. Interaction of human estrogen receptors alpha and beta with the same naturally occurring estrogen response elements
29. PPARγ as a novel target in cancer therapy: Binding and activation by an aromatic fatty acid with clinical antitumor activity
30. Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements
31. Peroxisome proliferator-activated receptors: Structures and function
32. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor
33. Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs
34. The D-type cyclins and their role in tumorigenesis
35. 17β-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells
36. Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells