Evidence for mutation showers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 20, 2007, Pages 8403-8408

  Wang, Jicheng ^a   Gonzalez, Kelly D ^a   Scaringe, William A ^a   Tsai, Kimberly ^a   Liu, Ning ^a   Gu, Dongqing ^a   Li, Wenyan ^a   Hill, Kathleen A ^a,b   Sommer, Steve S ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Big Blue mouse; lacI transgene; Multiple mutations; Mutation clusters; Transient hypermutability

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENETICS; CARCINOGENESIS; CONTROLLED STUDY; GENE MUTATION; GENE SEQUENCE; INTRON; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; TRANSGENIC MOUSE; ANIMAL; BASE PAIRING; BIOLOGICAL MODEL; C57BL MOUSE; GENE FREQUENCY; GENE VECTOR; GENETICS; MALE; MUTATION; NEOPLASM;

MUS MUSCULUS;

BACTERIAL PROTEIN; LACI PROTEIN, BACTERIA; MUTAGENIC AGENT; REPRESSOR PROTEIN; SPACER DNA; UNCLASSIFIED DRUG;

ANIMALS; BACTERIAL PROTEINS; BASE PAIRING; DNA, INTERGENIC; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENETIC VECTORS; INTRONS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, GENETIC; MUTAGENS; MUTATION; NEOPLASMS; REPRESSOR PROTEINS;

EID: 34347214120     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610902104     Document Type: Article

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