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Volumn 86, Issue 14, 2008, Pages 3170-3183

Distinct pattern of microglial response, cyclooxygenase-2, and inducible nitric oxide synthase expression in the aged rat brain after excitotoxic damage

Author keywords

Aging; Inflammation; Macrophage; Neutrophil; Striatum

Indexed keywords

CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE;

EID: 57049102293     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21751     Document Type: Article
Times cited : (27)

References (83)
  • 1
    • 0028364108 scopus 로고
    • Demonstration of poly-N-acetyl lactosamine residues in amoeboid and ramified microglial cells in rat brain by tomato lectin binding
    • Acarin L, Vela JM, Gonzalez B, Castellano B. 1994. Demonstration of poly-N-acetyl lactosamine residues in amoeboid and ramified microglial cells in rat brain by tomato lectin binding. J Histochem Cytochem 42:1033-1041.
    • (1994) J Histochem Cytochem , vol.42 , pp. 1033-1041
    • Acarin, L.1    Vela, J.M.2    Gonzalez, B.3    Castellano, B.4
  • 2
    • 0036790816 scopus 로고    scopus 로고
    • Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage
    • Acarin L, Gonzalez B, Castellano B. 2002a. Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage. Stroke 33:2499-2505.
    • (2002) Stroke , vol.33 , pp. 2499-2505
    • Acarin, L.1    Gonzalez, B.2    Castellano, B.3
  • 3
    • 0037097249 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and cyclooxygenase-2 after excitotoxic damage to the immature rat brain
    • Acarin L, Peluffo H, Gonzalez B, Castellano B. 2002b. Expression of inducible nitric oxide synthase and cyclooxygenase-2 after excitotoxic damage to the immature rat brain. J Neurosci Res 68:745-754.
    • (2002) J Neurosci Res , vol.68 , pp. 745-754
    • Acarin, L.1    Peluffo, H.2    Gonzalez, B.3    Castellano, B.4
  • 4
    • 0030031692 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induction in cerebral cortex: An intracellular response to synaptic excitation
    • Adams J, Collaco-Moraes Y, de Belleroche J. 1996. Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation. J Neurochem 66:6-13.
    • (1996) J Neurochem , vol.66 , pp. 6-13
    • Adams, J.1    Collaco-Moraes, Y.2    de Belleroche, J.3
  • 5
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F. 2001. Immune function of microglia. Glia 36:165-179.
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 8
    • 0033664686 scopus 로고    scopus 로고
    • Unilateral upregulation of cyclooxygenase-2 following cerebral, cortical photothrombosis in the rat: Suppression by MK-801 and codistribution with enzymes involved in the oxidative stress cascade
    • Bidmon HJ, Oermann E, Schiene K, Schmitt M, Kato K, Asayama K, Witte OW, Zilles K. 2000. Unilateral upregulation of cyclooxygenase-2 following cerebral, cortical photothrombosis in the rat: suppression by MK-801 and codistribution with enzymes involved in the oxidative stress cascade. J Chem Neuroanat 20:163-176.
    • (2000) J Chem Neuroanat , vol.20 , pp. 163-176
    • Bidmon, H.J.1    Oermann, E.2    Schiene, K.3    Schmitt, M.4    Kato, K.5    Asayama, K.6    Witte, O.W.7    Zilles, K.8
  • 9
    • 0037411508 scopus 로고    scopus 로고
    • Age effect on motor recovery in a post-acute animal stroke model
    • Brown AW, Marlowe KJ, Bjelke B. 2003. Age effect on motor recovery in a post-acute animal stroke model. Neurobiol Aging 24:607-614.
    • (2003) Neurobiol Aging , vol.24 , pp. 607-614
    • Brown, A.W.1    Marlowe, K.J.2    Bjelke, B.3
  • 10
    • 0036569812 scopus 로고    scopus 로고
    • Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat
    • Casolini P, Catalani A, Zuena AR, Angelucci L. 2002. Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. J Neurosci Res 68:337-343.
    • (2002) J Neurosci Res , vol.68 , pp. 337-343
    • Casolini, P.1    Catalani, A.2    Zuena, A.R.3    Angelucci, L.4
  • 11
    • 33847753069 scopus 로고    scopus 로고
    • Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain
    • Castillo-Ruiz MM, Campuzano O, Acarin L, Castellano B, Gonzalez B. 2007. Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain. Exp Gerontol 42:343-354.
    • (2007) Exp Gerontol , vol.42 , pp. 343-354
    • Castillo-Ruiz, M.M.1    Campuzano, O.2    Acarin, L.3    Castellano, B.4    Gonzalez, B.5
  • 12
    • 29244445803 scopus 로고    scopus 로고
    • Differential regulation of cyclooxygenase-2 in the rat hippocampus after cerebral ischemia and ischemic tolerance
    • Choi JS, Kim HY, Chun MH, Chung JW, Lee MY. 2006. Differential regulation of cyclooxygenase-2 in the rat hippocampus after cerebral ischemia and ischemic tolerance. Neurosci Lett 393:231-236.
    • (2006) Neurosci Lett , vol.393 , pp. 231-236
    • Choi, J.S.1    Kim, H.Y.2    Chun, M.H.3    Chung, J.W.4    Lee, M.Y.5
  • 13
    • 3843082003 scopus 로고    scopus 로고
    • Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death
    • Chu K, Jeong SW, Jung KH, Han SY, Lee ST, Kim M, Roh JK. 2004. Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. J Cereb Blood Flow Metab 24:926-933.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 926-933
    • Chu, K.1    Jeong, S.W.2    Jung, K.H.3    Han, S.Y.4    Lee, S.T.5    Kim, M.6    Roh, J.K.7
  • 16
    • 1642483509 scopus 로고    scopus 로고
    • Neurodegenerative diseases and oxidative stress
    • Emerit J, Edeas M, Bricaire F. 2004. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 58:39-46.
    • (2004) Biomed Pharmacother , vol.58 , pp. 39-46
    • Emerit, J.1    Edeas, M.2    Bricaire, F.3
  • 17
    • 0028240615 scopus 로고
    • Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia
    • Endoh M, Maiese K, Wagner J. 1994. Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res 651:92-100.
    • (1994) Brain Res , vol.651 , pp. 92-100
    • Endoh, M.1    Maiese, K.2    Wagner, J.3
  • 20
    • 0026077959 scopus 로고
    • Glutamate, nitric oxide and cell-cell signalling in the nervous system
    • Garthwaite J. 1991. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 14:60-67.
    • (1991) Trends Neurosci , vol.14 , pp. 60-67
    • Garthwaite, J.1
  • 21
    • 0028917372 scopus 로고
    • Nitric oxide signaling in the central nervous system
    • Garthwaite J, Boulton CL. 1995. Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706.
    • (1995) Annu Rev Physiol , vol.57 , pp. 683-706
    • Garthwaite, J.1    Boulton, C.L.2
  • 22
    • 33750480549 scopus 로고    scopus 로고
    • The age-related attenuation in long-term potentiation is associated with microglial activation
    • Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA. 2006. The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 99:1263-1272.
    • (2006) J Neurochem , vol.99 , pp. 1263-1272
    • Griffin, R.1    Nally, R.2    Nolan, Y.3    McCartney, Y.4    Linden, J.5    Lynch, M.A.6
  • 23
    • 0032494270 scopus 로고    scopus 로고
    • Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid
    • Hashimoto K, Watanabe K, Nishimura T, Iyo M, Shirayama Y, Minabe Y. 1998. Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid. Brain Res 804:212-223.
    • (1998) Brain Res , vol.804 , pp. 212-223
    • Hashimoto, K.1    Watanabe, K.2    Nishimura, T.3    Iyo, M.4    Shirayama, Y.5    Minabe, Y.6
  • 24
    • 0020074668 scopus 로고
    • Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response
    • Hoff SF, Scheff SW, Cotman CW. 1982. Lesion-induced synaptogenesis in the dentate gyrus of aged rats: II. Demonstration of an impaired degeneration clearing response. J Comp Neurol 205:253-259.
    • (1982) J Comp Neurol , vol.205 , pp. 253-259
    • Hoff, S.F.1    Scheff, S.W.2    Cotman, C.W.3
  • 25
    • 0035143182 scopus 로고    scopus 로고
    • Cerebral ischemia and inflammation
    • Iadecola C, Alexander M. 2001. Cerebral ischemia and inflammation. Curr Opin Neurol 14:89-94.
    • (2001) Curr Opin Neurol , vol.14 , pp. 89-94
    • Iadecola, C.1    Alexander, M.2
  • 26
    • 0029294575 scopus 로고
    • Inducible nitric oxide synthase gene expression in brain following cerebral ischemia
    • Iadecola C, Zhang F, Xu S, Casey R, Ross ME. 1995a. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 378-384
    • Iadecola, C.1    Zhang, F.2    Xu, S.3    Casey, R.4    Ross, M.E.5
  • 27
    • 0028891572 scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
    • Iadecola C, Zhang F, Xu X. 1995b. Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268: R286-R292.
    • (1995) Am J Physiol , vol.268
    • Iadecola, C.1    Zhang, F.2    Xu, X.3
  • 28
    • 0035970036 scopus 로고    scopus 로고
    • Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
    • Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S, Ross ME. 2001. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci U S A 98:1294-1299.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1294-1299
    • Iadecola, C.1    Niwa, K.2    Nogawa, S.3    Zhao, X.4    Nagayama, M.5    Araki, E.6    Morham, S.7    Ross, M.E.8
  • 29
    • 7744232267 scopus 로고    scopus 로고
    • Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration
    • Iravani MM, Liu L, Rose S, Jenner P. 2004. Role of inducible nitric oxide synthase in N-methyl-d-aspartic acid-induced strio-nigral degeneration. Brain Res 1029:103-113.
    • (2004) Brain Res , vol.1029 , pp. 103-113
    • Iravani, M.M.1    Liu, L.2    Rose, S.3    Jenner, P.4
  • 30
    • 0033105503 scopus 로고    scopus 로고
    • The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats
    • Jacob JM, Dorheim MA, Grammas P. 1999. The effect of age and injury on the expression of inducible nitric oxide synthase in facial motor neurons in F344 rats. Mech Ageing Dev 107:205-218.
    • (1999) Mech Ageing Dev , vol.107 , pp. 205-218
    • Jacob, J.M.1    Dorheim, M.A.2    Grammas, P.3
  • 31
    • 0029995029 scopus 로고    scopus 로고
    • COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex
    • Kaufmann WE, Worley PF, Pegg J, Bremer M, Isakson P. 1996. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc Natl Acad Sci U S A 93:2317-2321.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 2317-2321
    • Kaufmann, W.E.1    Worley, P.F.2    Pegg, J.3    Bremer, M.4    Isakson, P.5
  • 33
    • 0035479019 scopus 로고    scopus 로고
    • Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged vs. young rats following cortical stab injury
    • Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA. 2001. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged vs. young rats following cortical stab injury. J Neuroimmunol 119:269-277.
    • (2001) J Neuroimmunol , vol.119 , pp. 269-277
    • Kyrkanides, S.1    O'Banion, M.K.2    Whiteley, P.E.3    Daeschner, J.C.4    Olschowka, J.A.5
  • 35
    • 0031709875 scopus 로고    scopus 로고
    • iNOS contribution to the NMDA-induced excitotoxic lesion in the rat striatum
    • Lecanu L, Verrecchia C, Margaill I, Boulu RG, Plotkine M. 1998b. iNOS contribution to the NMDA-induced excitotoxic lesion in the rat striatum. Br J Pharmacol 125:584-590.
    • (1998) Br J Pharmacol , vol.125 , pp. 584-590
    • Lecanu, L.1    Verrecchia, C.2    Margaill, I.3    Boulu, R.G.4    Plotkine, M.5
  • 36
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen A, Matz P, Chan PH. 2000. Free radical pathways in CNS injury. J Neurotrauma 17:871-890.
    • (2000) J Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 40
    • 12244257527 scopus 로고    scopus 로고
    • Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death
    • Mander P, Borutaite V, Moncada S, Brown GC. 2005. Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. J Neurosci Res 79:208-215.
    • (2005) J Neurosci Res , vol.79 , pp. 208-215
    • Mander, P.1    Borutaite, V.2    Moncada, S.3    Brown, G.C.4
  • 42
    • 0033503988 scopus 로고    scopus 로고
    • Phosphorylation of c-Jun and its localization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia
    • Matsuoka Y, Okazaki M, Zhao H, Asai S, Ishikawa K, Kitamura Y. 1999. Phosphorylation of c-Jun and its localization with heme oxygenase-1 and cyclooxygenase-2 in CA1 pyramidal neurons after transient forebrain ischemia. J Cereb Blood Flow Metab 19:1247-1255.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1247-1255
    • Matsuoka, Y.1    Okazaki, M.2    Zhao, H.3    Asai, S.4    Ishikawa, K.5    Kitamura, Y.6
  • 43
    • 0043180531 scopus 로고    scopus 로고
    • Excitotoxic and excitoprotective mechanisms: Abundant targets for the prevention and treatment of neurodegenerative disorders
    • Mattson MP. 2003. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromol Med 3:65-94.
    • (2003) Neuromol Med , vol.3 , pp. 65-94
    • Mattson, M.P.1
  • 46
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti L. 2004. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 63:901-910.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 901-910
    • Minghetti, L.1
  • 47
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
    • Minghetti L, Levi G. 1998. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54:99-125.
    • (1998) Prog Neurobiol , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 48
    • 22944434894 scopus 로고    scopus 로고
    • Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors
    • Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D. 2005. Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 57:217-252.
    • (2005) Pharmacol Rev , vol.57 , pp. 217-252
    • Mollace, V.1    Muscoli, C.2    Masini, E.3    Cuzzocrea, S.4    Salvemini, D.5
  • 49
    • 0031714239 scopus 로고    scopus 로고
    • Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats
    • Nagayama M, Zhang F, Iadecola C. 1998. Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats. J Cereb Blood Flow Metab 18:1107-1113.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 1107-1113
    • Nagayama, M.1    Zhang, F.2    Iadecola, C.3
  • 50
    • 0028273120 scopus 로고
    • The influence of age on stroke outcome. The Copenhagen Stroke Study
    • Nakayama H, Jorgensen HS, Raaschou HO, Olsen TS. 1994. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 25:808-813.
    • (1994) Stroke , vol.25 , pp. 808-813
    • Nakayama, H.1    Jorgensen, H.S.2    Raaschou, H.O.3    Olsen, T.S.4
  • 51
    • 0030909616 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • Nogawa S, Zhang F, Ross ME, Iadecola C. 1997. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755.
    • (1997) J Neurosci , vol.17 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Ross, M.E.3    Iadecola, C.4
  • 52
    • 0032167857 scopus 로고    scopus 로고
    • Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia
    • Nogawa S, Forster C, Zhang F, Nagayama M, Ross ME, Iadecola C. 1998. Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. Proc Natl Acad Sci U S A 95:10966-10971.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 10966-10971
    • Nogawa, S.1    Forster, C.2    Zhang, F.3    Nagayama, M.4    Ross, M.E.5    Iadecola, C.6
  • 53
    • 0032846525 scopus 로고    scopus 로고
    • COX-2 and Alzheimer's disease: Potential roles in inflammation and neurodegeneration
    • O'Banion MK. 1999. COX-2 and Alzheimer's disease: potential roles in inflammation and neurodegeneration. Expert Opin Invest Drugs 8:1521-1536.
    • (1999) Expert Opin Invest Drugs , vol.8 , pp. 1521-1536
    • O'Banion, M.K.1
  • 57
    • 0035000952 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase-2 expression by nitric oxide in cells
    • Perez-Sala D, Lamas S. 2001. Regulation of cyclooxygenase-2 expression by nitric oxide in cells. Antiox Redox Signal 3:231-248.
    • (2001) Antiox Redox Signal , vol.3 , pp. 231-248
    • Perez-Sala, D.1    Lamas, S.2
  • 58
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • Perry VH, Matyszak MK, Fearn S. 1993. Altered antigen expression of microglia in the aged rodent CNS. Glia 7:60-67.
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 59
    • 0036454716 scopus 로고    scopus 로고
    • Structural changes in the normally aging cerebral cortex of primates
    • Peters A. 2002. Structural changes in the normally aging cerebral cortex of primates. Prog Brain Res 136:455-465.
    • (2002) Prog Brain Res , vol.136 , pp. 455-465
    • Peters, A.1
  • 60
    • 0028884128 scopus 로고
    • Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain
    • Planas AM, Soriano MA, Rodriguez-Farre E, Ferrer I. 1995. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci Lett 200:187-190.
    • (1995) Neurosci Lett , vol.200 , pp. 187-190
    • Planas, A.M.1    Soriano, M.A.2    Rodriguez-Farre, E.3    Ferrer, I.4
  • 61
    • 0032692668 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage
    • Planas AM, Soriano MA, Justicia C, Rodriguez-Farre E. 1999. Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage. Neurosci Lett 275:141-144.
    • (1999) Neurosci Lett , vol.275 , pp. 141-144
    • Planas, A.M.1    Soriano, M.A.2    Justicia, C.3    Rodriguez-Farre, E.4
  • 62
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • Saha RN, Pahan K. 2006. Regulation of inducible nitric oxide synthase gene in glial cells. Antiox Redox Signal 8:929-947.
    • (2006) Antiox Redox Signal , vol.8 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 63
    • 5644241071 scopus 로고    scopus 로고
    • Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice
    • Sandhir R, Puri V, Klein RM, Berman NE. 2004. Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice. Neurosci Lett 369:28-32.
    • (2004) Neurosci Lett , vol.369 , pp. 28-32
    • Sandhir, R.1    Puri, V.2    Klein, R.M.3    Berman, N.E.4
  • 64
    • 0030748881 scopus 로고    scopus 로고
    • Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid
    • Sanz O, Estrada A, Ferrer I, Planas AM. 1997. Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience 80:221-232.
    • (1997) Neuroscience , vol.80 , pp. 221-232
    • Sanz, O.1    Estrada, A.2    Ferrer, I.3    Planas, A.M.4
  • 65
    • 0034089991 scopus 로고    scopus 로고
    • Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: Implication in Alzheimer's disease
    • Scali C, Prosperi C, Vannucchi MG, Pepeu G, Casamenti F. 2000. Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. Eur J Neurosci 12:1900-1912.
    • (2000) Eur J Neurosci , vol.12 , pp. 1900-1912
    • Scali, C.1    Prosperi, C.2    Vannucchi, M.G.3    Pepeu, G.4    Casamenti, F.5
  • 66
    • 0037430760 scopus 로고    scopus 로고
    • The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo
    • Scali C, Giovannini MG, Prosperi C, Bellucci A, Pepeu G, Casamenti F. 2003. The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. Neuroscience 117:909-919.
    • (2003) Neuroscience , vol.117 , pp. 909-919
    • Scali, C.1    Giovannini, M.G.2    Prosperi, C.3    Bellucci, A.4    Pepeu, G.5    Casamenti, F.6
  • 67
    • 0028997095 scopus 로고
    • Evidence for bidirectional changes in nitric oxide synthase activity in the rat striatum after excitotoxically (quinolinic acid) induced degeneration
    • Schmidt W, Wolf G, Calka J, Schmidt HH. 1995. Evidence for bidirectional changes in nitric oxide synthase activity in the rat striatum after excitotoxically (quinolinic acid) induced degeneration. Neuroscience 67:345-356.
    • (1995) Neuroscience , vol.67 , pp. 345-356
    • Schmidt, W.1    Wolf, G.2    Calka, J.3    Schmidt, H.H.4
  • 68
    • 0035054493 scopus 로고    scopus 로고
    • Glutamatergic neuro-transmission in aging: A critical perspective
    • Segovia G, Porras A, Del Arco A, Mora F. 2001. Glutamatergic neuro-transmission in aging: a critical perspective. Mech Ageing Dev 122:1-29.
    • (2001) Mech Ageing Dev , vol.122 , pp. 1-29
    • Segovia, G.1    Porras, A.2    Del Arco, A.3    Mora, F.4
  • 69
    • 0033852223 scopus 로고    scopus 로고
    • Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat
    • Strauss KI, Barbe MF, Marshall RM, Raghupathi R, Mehta S, Narayan RK. 2000. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma 17:695-711.
    • (2000) J Neurotrauma , vol.17 , pp. 695-711
    • Strauss, K.I.1    Barbe, M.F.2    Marshall, R.M.3    Raghupathi, R.4    Mehta, S.5    Narayan, R.K.6
  • 70
    • 0023213595 scopus 로고
    • Lectin binding by resting and reactive microglia
    • Streit WJ, Kreutzberg GW. 1987. Lectin binding by resting and reactive microglia. J Neurocytol 16:249-260.
    • (1987) J Neurocytol , vol.16 , pp. 249-260
    • Streit, W.J.1    Kreutzberg, G.W.2
  • 71
    • 0033952635 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans
    • Tomimoto H, Akiguchi I, Wakita H, Lin JX, Budka H. 2000. Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. Acta Neuropathol 99:26-30.
    • (2000) Acta Neuropathol , vol.99 , pp. 26-30
    • Tomimoto, H.1    Akiguchi, I.2    Wakita, H.3    Lin, J.X.4    Budka, H.5
  • 73
    • 21044442392 scopus 로고    scopus 로고
    • Prostaglandins and cyclooxygenases in glial cells during brain inflammation
    • Tzeng SF, Hsiao HY, Mak OT. 2005. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allerg 4:335-340.
    • (2005) Curr Drug Targets Inflamm Allerg , vol.4 , pp. 335-340
    • Tzeng, S.F.1    Hsiao, H.Y.2    Mak, O.T.3
  • 76
    • 0020957177 scopus 로고
    • Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats
    • Vijayan VK, Cotman CW. 1983. Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats. Neurobiol Aging 4:13-23.
    • (1983) Neurobiol Aging , vol.4 , pp. 13-23
    • Vijayan, V.K.1    Cotman, C.W.2
  • 77
  • 79
    • 0026732936 scopus 로고
    • Factors in.uencing long-term survival and disability among three-month stroke survivors
    • Woo J, Kay R, Yuen YK, Nicholls MG. 1992. Factors in.uencing long-term survival and disability among three-month stroke survivors. Neuroepidemiology 11:143-150.
    • (1992) Neuroepidemiology , vol.11 , pp. 143-150
    • Woo, J.1    Kay, R.2    Yuen, Y.K.3    Nicholls, M.G.4
  • 80
    • 4344595492 scopus 로고    scopus 로고
    • Mechanism of age-associated up-regulation in macrophage PGE2 synthesis
    • Wu D, Meydani SN. 2004. Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. Brain Behav Immun 18:487-494.
    • (2004) Brain Behav Immun , vol.18 , pp. 487-494
    • Wu, D.1    Meydani, S.N.2
  • 81
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
    • Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. 1993. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11:371-386.
    • (1993) Neuron , vol.11 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 83
    • 34247385436 scopus 로고    scopus 로고
    • Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression
    • Zhao X, Zhang Y, Strong R, Zhang J, Grotta JC, Aronowski J. 2007. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. J Neurochem 101:652-663.
    • (2007) J Neurochem , vol.101 , pp. 652-663
    • Zhao, X.1    Zhang, Y.2    Strong, R.3    Zhang, J.4    Grotta, J.C.5    Aronowski, J.6


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