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Volumn 42, Issue 4, 2007, Pages 343-354

Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain

Author keywords

Aging; Astrogliosis; Brain; Edema; Excitotoxicity; Experimental stroke; Fluoro Jade B; Neurodegeneration; Striatum

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; N METHYL DEXTRO ASPARTIC ACID; TOLONIUM CHLORIDE;

EID: 33847753069     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.10.008     Document Type: Article
Times cited : (27)

References (81)
  • 1
    • 0035783912 scopus 로고    scopus 로고
    • Glial activation in the immature rat brain: implication of inflammatory transcription factors and cytokine expression
    • Acarin L., Gonzalez B., and Castellano B. Glial activation in the immature rat brain: implication of inflammatory transcription factors and cytokine expression. Prog. Brain Res. 132 (2001) 375-389
    • (2001) Prog. Brain Res. , vol.132 , pp. 375-389
    • Acarin, L.1    Gonzalez, B.2    Castellano, B.3
  • 2
    • 0345086470 scopus 로고    scopus 로고
    • Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression
    • Acarin L., Gonzalez B., Hidalgo J., Castro A.J., and Castellano B. Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression. Neuroscience 92 (1999) 827-839
    • (1999) Neuroscience , vol.92 , pp. 827-839
    • Acarin, L.1    Gonzalez, B.2    Hidalgo, J.3    Castro, A.J.4    Castellano, B.5
  • 3
    • 0032191725 scopus 로고    scopus 로고
    • Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study
    • Amenta F., Bronzetti E., Sabbatini M., and Vega J.A. Astrocyte changes in aging cerebral cortex and hippocampus: a quantitative immunohistochemical study. Microsc. Res. Tech. 43 (1998) 29-33
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 29-33
    • Amenta, F.1    Bronzetti, E.2    Sabbatini, M.3    Vega, J.A.4
  • 5
    • 0344394955 scopus 로고    scopus 로고
    • Temporal dynamics of degenerative and regenerative events associated with cerebral ischemia in aged rats
    • Badan I., Platt D., Kessler C., and Popa-Wagner A. Temporal dynamics of degenerative and regenerative events associated with cerebral ischemia in aged rats. Gerontology 49 (2003) 356-365
    • (2003) Gerontology , vol.49 , pp. 356-365
    • Badan, I.1    Platt, D.2    Kessler, C.3    Popa-Wagner, A.4
  • 6
    • 4544340146 scopus 로고    scopus 로고
    • Cytokines and the aging brain - what we don't know might help us
    • Bodles A.M., and Barger S.W. Cytokines and the aging brain - what we don't know might help us. Trends Neurosci. 27 (2004) 621-626
    • (2004) Trends Neurosci. , vol.27 , pp. 621-626
    • Bodles, A.M.1    Barger, S.W.2
  • 7
    • 0030704727 scopus 로고    scopus 로고
    • Prevalence of stroke and stroke-related disability. Estimates from the Auckland stroke studies
    • Bonita R., Solomon N., and Broad J.B. Prevalence of stroke and stroke-related disability. Estimates from the Auckland stroke studies. Stroke 28 (1997) 1898-1902
    • (1997) Stroke , vol.28 , pp. 1898-1902
    • Bonita, R.1    Solomon, N.2    Broad, J.B.3
  • 8
    • 0027740208 scopus 로고
    • Neurite outgrowth inhibitors associated with glial cells and glial cell lines
    • Bovolenta P., Wandosell F., and Nieto-Sampedro M. Neurite outgrowth inhibitors associated with glial cells and glial cell lines. Neuroreport 5 (1993) 345-348
    • (1993) Neuroreport , vol.5 , pp. 345-348
    • Bovolenta, P.1    Wandosell, F.2    Nieto-Sampedro, M.3
  • 9
    • 0027156673 scopus 로고
    • Age-related gliosis in the white matter of mice
    • Bronson R.T., Lipman R.D., and Harrison D.E. Age-related gliosis in the white matter of mice. Brain Res. 609 (1993) 124-128
    • (1993) Brain Res. , vol.609 , pp. 124-128
    • Bronson, R.T.1    Lipman, R.D.2    Harrison, D.E.3
  • 10
    • 0037411508 scopus 로고    scopus 로고
    • Age effect on motor recovery in a post-acute animal stroke model
    • Brown A.W., Marlowe K.J., and Bjelke B. Age effect on motor recovery in a post-acute animal stroke model. Neurobiol. Aging 24 (2003) 607-614
    • (2003) Neurobiol. Aging , vol.24 , pp. 607-614
    • Brown, A.W.1    Marlowe, K.J.2    Bjelke, B.3
  • 11
    • 0142040778 scopus 로고    scopus 로고
    • The epidemiology of traumatic brain injury: a review
    • Bruns Jr. J., and Hauser W.A. The epidemiology of traumatic brain injury: a review. Epilepsia 44 Suppl. 10 (2003) 2-10
    • (2003) Epilepsia , vol.44 , Issue.SUPPL. 10 , pp. 2-10
    • Bruns Jr., J.1    Hauser, W.A.2
  • 12
    • 0032174031 scopus 로고    scopus 로고
    • Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?
    • Budd S.L., and Lipton S.A. Calcium tsunamis: do astrocytes transmit cell death messages via gap junctions during ischemia?. Nat. Neurosci. 1 (1998) 431-432
    • (1998) Nat. Neurosci. , vol.1 , pp. 431-432
    • Budd, S.L.1    Lipton, S.A.2
  • 13
    • 1842525777 scopus 로고    scopus 로고
    • Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state
    • Calabrese V., Scapagnini G., Ravagna A., Colombrita C., Spadaro F., Butterfield D.A., and Giuffrida Stella A.M. Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech. Ageing Dev. 125 (2004) 325-335
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 325-335
    • Calabrese, V.1    Scapagnini, G.2    Ravagna, A.3    Colombrita, C.4    Spadaro, F.5    Butterfield, D.A.6    Giuffrida Stella, A.M.7
  • 15
    • 0035906514 scopus 로고    scopus 로고
    • Expression and function of astrocytic gap junctions in aging
    • Cotrina M.L., Gao Q., Lin J.H., and Nedergaard M. Expression and function of astrocytic gap junctions in aging. Brain Res. 901 (2001) 55-61
    • (2001) Brain Res. , vol.901 , pp. 55-61
    • Cotrina, M.L.1    Gao, Q.2    Lin, J.H.3    Nedergaard, M.4
  • 18
    • 0029025265 scopus 로고
    • Experimental stroke and neuroprotection in the aging rat brain
    • Davis M., Mendelow A.D., Perry R.H., Chambers I.R., and James O.F. Experimental stroke and neuroprotection in the aging rat brain. Stroke 26 (1995) 1072-1078
    • (1995) Stroke , vol.26 , pp. 1072-1078
    • Davis, M.1    Mendelow, A.D.2    Perry, R.H.3    Chambers, I.R.4    James, O.F.5
  • 20
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 21
    • 0038060334 scopus 로고    scopus 로고
    • Ischemic tolerance and endogenous neuroprotection
    • Dirnagl U., Simon R.P., and Hallenbeck J.M. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 26 (2003) 248-254
    • (2003) Trends Neurosci. , vol.26 , pp. 248-254
    • Dirnagl, U.1    Simon, R.P.2    Hallenbeck, J.M.3
  • 22
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: implications for therapy
    • Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Ther. 81 (1999) 163-221
    • (1999) Pharmacol. Ther. , vol.81 , pp. 163-221
    • Doble, A.1
  • 23
    • 0023801585 scopus 로고
    • The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age
    • Duverger D., and MacKenzie E.T. The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age. J. Cereb. Blood Flow Metab. 8 (1988) 449-461
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 449-461
    • Duverger, D.1    MacKenzie, E.T.2
  • 24
    • 0034305621 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
    • Eng L.F., Ghirnikar R.S., and Lee Y.L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 25 (2000) 1439-1451
    • (2000) Neurochem. Res. , vol.25 , pp. 1439-1451
    • Eng, L.F.1    Ghirnikar, R.S.2    Lee, Y.L.3
  • 25
    • 0038198881 scopus 로고    scopus 로고
    • Neurons, glia, and plasticity in normal brain aging
    • discussion S131
    • Finch C.E. Neurons, glia, and plasticity in normal brain aging. Neurobiol. Aging 24 Suppl. 1 (2003) S123-S127 discussion S131
    • (2003) Neurobiol. Aging , vol.24 , Issue.SUPPL. 1
    • Finch, C.E.1
  • 26
    • 0026623479 scopus 로고
    • Calcium waves in astrocytes-filling in the gaps
    • Finkbeiner S. Calcium waves in astrocytes-filling in the gaps. Neuron 8 (1992) 1101-1108
    • (1992) Neuron , vol.8 , pp. 1101-1108
    • Finkbeiner, S.1
  • 27
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247
    • (2000) Nature , vol.408 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 28
    • 0036751954 scopus 로고    scopus 로고
    • Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
    • Floyd R.A., and Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol. Aging 23 (2002) 795-807
    • (2002) Neurobiol. Aging , vol.23 , pp. 795-807
    • Floyd, R.A.1    Hensley, K.2
  • 29
    • 0033780790 scopus 로고    scopus 로고
    • Oedema and glial cell involvement in the aged mouse brain after permanent focal ischaemia
    • Fotheringham A.P., Davies C.A., and Davies I. Oedema and glial cell involvement in the aged mouse brain after permanent focal ischaemia. Neuropathol. Appl. Neurobiol. 26 (2000) 412-423
    • (2000) Neuropathol. Appl. Neurobiol. , vol.26 , pp. 412-423
    • Fotheringham, A.P.1    Davies, C.A.2    Davies, I.3
  • 30
    • 0035910375 scopus 로고    scopus 로고
    • Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia
    • Fujimura M., Morita-Fujimura Y., Copin J., Yoshimoto T., and Chan P.H. Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia. Brain Res. 889 (2001) 208-213
    • (2001) Brain Res. , vol.889 , pp. 208-213
    • Fujimura, M.1    Morita-Fujimura, Y.2    Copin, J.3    Yoshimoto, T.4    Chan, P.H.5
  • 32
    • 7644225298 scopus 로고    scopus 로고
    • Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits
    • Gong Y., Hua Y., Keep R.F., Hoff J.T., and Xi G. Intracerebral hemorrhage: effects of aging on brain edema and neurological deficits. Stroke 35 (2004) 2571-2575
    • (2004) Stroke , vol.35 , pp. 2571-2575
    • Gong, Y.1    Hua, Y.2    Keep, R.F.3    Hoff, J.T.4    Xi, G.5
  • 33
    • 0028815397 scopus 로고
    • Enhanced glial fibrillary acidic protein RNA response to fornix transection in aged mice
    • Goss J.R., and Morgan D.G. Enhanced glial fibrillary acidic protein RNA response to fornix transection in aged mice. J. Neurochem. 64 (1995) 1351-1360
    • (1995) J. Neurochem. , vol.64 , pp. 1351-1360
    • Goss, J.R.1    Morgan, D.G.2
  • 34
    • 0031911320 scopus 로고    scopus 로고
    • Large infarcts in the middle cerebral artery territory. Etiology and outcome patterns
    • Heinsius T., Bogousslavsky J., and Van Melle G. Large infarcts in the middle cerebral artery territory. Etiology and outcome patterns. Neurology 50 (1998) 341-350
    • (1998) Neurology , vol.50 , pp. 341-350
    • Heinsius, T.1    Bogousslavsky, J.2    Van Melle, G.3
  • 35
    • 0037404612 scopus 로고    scopus 로고
    • Facial nerve axotomy in aged and young adult rats: analysis of the glial response
    • Hurley S.D., and Coleman P.D. Facial nerve axotomy in aged and young adult rats: analysis of the glial response. Neurobiol. Aging 24 (2003) 511-518
    • (2003) Neurobiol. Aging , vol.24 , pp. 511-518
    • Hurley, S.D.1    Coleman, P.D.2
  • 36
    • 0031020172 scopus 로고    scopus 로고
    • Bright and dark sides of nitric oxide in ischemic brain injury
    • Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20 (1997) 132-139
    • (1997) Trends Neurosci. , vol.20 , pp. 132-139
    • Iadecola, C.1
  • 37
    • 0030805904 scopus 로고    scopus 로고
    • Astrocytes in the aged rat spinal cord fail to increase GFAP mRNA following sciatic nerve axotomy
    • Kane C.J., Sims T.J., and Gilmore S.A. Astrocytes in the aged rat spinal cord fail to increase GFAP mRNA following sciatic nerve axotomy. Brain Res. 759 (1997) 163-165
    • (1997) Brain Res. , vol.759 , pp. 163-165
    • Kane, C.J.1    Sims, T.J.2    Gilmore, S.A.3
  • 38
    • 0034054903 scopus 로고    scopus 로고
    • Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia
    • discussion B142-3
    • Kharlamov A., Kharlamov E., and Armstrong D.M. Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia. J. Gerontol. A Biol. Sci. Med. Sci. 55 (2000) B135-B141 discussion B142-3
    • (2000) J. Gerontol. A Biol. Sci. Med. Sci. , vol.55
    • Kharlamov, A.1    Kharlamov, E.2    Armstrong, D.M.3
  • 39
    • 9344258586 scopus 로고    scopus 로고
    • Water homeostasis in the brain: basic concepts
    • Kimelberg H.K. Water homeostasis in the brain: basic concepts. Neuroscience 129 (2004) 851-860
    • (2004) Neuroscience , vol.129 , pp. 851-860
    • Kimelberg, H.K.1
  • 40
    • 0027519170 scopus 로고
    • Reduction of striatal N-methyl-d-aspartate toxicity by inhibition of nitric oxide synthase
    • Kollegger H., McBean G.J., and Tipton K.F. Reduction of striatal N-methyl-d-aspartate toxicity by inhibition of nitric oxide synthase. Biochem. Pharmacol. 45 (1993) 260-264
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 260-264
    • Kollegger, H.1    McBean, G.J.2    Tipton, K.F.3
  • 41
    • 0030960606 scopus 로고    scopus 로고
    • Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
    • Korhonen P., Helenius M., and Salminen A. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci. Lett. 225 (1997) 61-64
    • (1997) Neurosci. Lett. , vol.225 , pp. 61-64
    • Korhonen, P.1    Helenius, M.2    Salminen, A.3
  • 42
    • 0035479019 scopus 로고    scopus 로고
    • Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury
    • Kyrkanides S., O'Banion M.K., Whiteley P.E., Daeschner J.C., and Olschowka J.A. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J. Neuroimmunol. 119 (2001) 269-277
    • (2001) J. Neuroimmunol. , vol.119 , pp. 269-277
    • Kyrkanides, S.1    O'Banion, M.K.2    Whiteley, P.E.3    Daeschner, J.C.4    Olschowka, J.A.5
  • 43
    • 0017342282 scopus 로고
    • Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats
    • Landfield P.W., Rose G., Sandles L., Wohlstadter T.C., and Lynch G. Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of ages, memory-deficient rats. J. Gerontol. 32 (1977) 3-12
    • (1977) J. Gerontol. , vol.32 , pp. 3-12
    • Landfield, P.W.1    Rose, G.2    Sandles, L.3    Wohlstadter, T.C.4    Lynch, G.5
  • 44
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee C.K., Weindruch R., and Prolla T.A. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25 (2000) 294-297
    • (2000) Nat. Genet. , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 45
    • 0027519254 scopus 로고
    • Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats
    • Lin T.N., He Y.Y., Wu G., Khan M., and Hsu C.Y. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24 (1993) 117-121
    • (1993) Stroke , vol.24 , pp. 117-121
    • Lin, T.N.1    He, Y.Y.2    Wu, G.3    Khan, M.4    Hsu, C.Y.5
  • 47
    • 0043180531 scopus 로고    scopus 로고
    • Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders
    • Mattson M.P. Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders. Neuromolecular Med. 3 (2003) 65-94
    • (2003) Neuromolecular Med. , vol.3 , pp. 65-94
    • Mattson, M.P.1
  • 48
    • 0025362422 scopus 로고
    • Differential effects of advancing age on neurotransmitter cell loss in the substantia nigra and striatum of C57BL/6N mice
    • McNeill T.H., and Koek L.L. Differential effects of advancing age on neurotransmitter cell loss in the substantia nigra and striatum of C57BL/6N mice. Brain Res. 521 (1990) 107-117
    • (1990) Brain Res. , vol.521 , pp. 107-117
    • McNeill, T.H.1    Koek, L.L.2
  • 49
    • 0031985513 scopus 로고    scopus 로고
    • Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide
    • Minghetti L., and Levi G. Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog. Neurobiol. 54 (1998) 99-125
    • (1998) Prog. Neurobiol. , vol.54 , pp. 99-125
    • Minghetti, L.1    Levi, G.2
  • 52
    • 0028273120 scopus 로고
    • The influence of age on stroke outcome. The Copenhagen Stroke Study
    • Nakayama H., Jorgensen H.S., Raaschou H.O., and Olsen T.S. The influence of age on stroke outcome. The Copenhagen Stroke Study. Stroke 25 (1994) 808-813
    • (1994) Stroke , vol.25 , pp. 808-813
    • Nakayama, H.1    Jorgensen, H.S.2    Raaschou, H.O.3    Olsen, T.S.4
  • 53
    • 20344394153 scopus 로고    scopus 로고
    • Role of glial cells in cerebral ischemia
    • Nedergaard M., and Dirnagl U. Role of glial cells in cerebral ischemia. Glia 50 (2005) 281-286
    • (2005) Glia , vol.50 , pp. 281-286
    • Nedergaard, M.1    Dirnagl, U.2
  • 54
    • 0034698252 scopus 로고    scopus 로고
    • Blocking the glycine-binding site of NMDA receptors prevents the progression of ischemic pathology induced by bilateral carotid artery occlusion in spontaneously hypertensive rats
    • Ohtani K., Tanaka H., Yasuda H., Maruoka Y., Kawabe A., and Nakamura M. Blocking the glycine-binding site of NMDA receptors prevents the progression of ischemic pathology induced by bilateral carotid artery occlusion in spontaneously hypertensive rats. Brain Res. 871 (2000) 311-318
    • (2000) Brain Res. , vol.871 , pp. 311-318
    • Ohtani, K.1    Tanaka, H.2    Yasuda, H.3    Maruoka, Y.4    Kawabe, A.5    Nakamura, M.6
  • 55
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate
    • Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science 164 (1969) 719-721
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 56
    • 0032191043 scopus 로고    scopus 로고
    • Histology and histochemistry of the aging cerebral cortex: an overview
    • Peinado M.A. Histology and histochemistry of the aging cerebral cortex: an overview. Microsc. Res. Tech. 43 (1998) 1-7
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 1-7
    • Peinado, M.A.1
  • 57
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M., and Nilsson M. Astrocyte activation and reactive gliosis. Glia 50 (2005) 427-434
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 58
    • 0030028486 scopus 로고    scopus 로고
    • Mechanisms of intracellular calcium regulation in adult astrocytes
    • Peuchen S., Clark J.B., and Duchen M.R. Mechanisms of intracellular calcium regulation in adult astrocytes. Neuroscience 71 (1996) 871-883
    • (1996) Neuroscience , vol.71 , pp. 871-883
    • Peuchen, S.1    Clark, J.B.2    Duchen, M.R.3
  • 60
    • 0038375823 scopus 로고    scopus 로고
    • A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging
    • Scahill R.I., Frost C., Jenkins R., Whitwell J.L., Rossor M.N., and Fox N.C. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch. Neurol. 60 (2003) 989-994
    • (2003) Arch. Neurol. , vol.60 , pp. 989-994
    • Scahill, R.I.1    Frost, C.2    Jenkins, R.3    Whitwell, J.L.4    Rossor, M.N.5    Fox, N.C.6
  • 61
    • 0018894530 scopus 로고
    • Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal
    • Scheff S.W., Benardo L.S., and Cotman C.W. Decline in reactive fiber growth in the dentate gyrus of aged rats compared to young adult rats following entorhinal cortex removal. Brain Res. 199 (1980) 21-38
    • (1980) Brain Res. , vol.199 , pp. 21-38
    • Scheff, S.W.1    Benardo, L.S.2    Cotman, C.W.3
  • 62
    • 0034714392 scopus 로고    scopus 로고
    • Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    • Schmued L.C., and Hopkins K.J. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 874 (2000) 123-130
    • (2000) Brain Res. , vol.874 , pp. 123-130
    • Schmued, L.C.1    Hopkins, K.J.2
  • 63
    • 0035054493 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission in aging: a critical perspective
    • Segovia G., Porras A., Del Arco A., and Mora F. Glutamatergic neurotransmission in aging: a critical perspective. Mech. Ageing Dev. 122 (2001) 1-29
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1-29
    • Segovia, G.1    Porras, A.2    Del Arco, A.3    Mora, F.4
  • 64
    • 0030812065 scopus 로고    scopus 로고
    • Age-related changes in the blood-brain barrier
    • Shah G.N., and Mooradian A.D. Age-related changes in the blood-brain barrier. Exp. Gerontol. 32 (1997) 501-519
    • (1997) Exp. Gerontol. , vol.32 , pp. 501-519
    • Shah, G.N.1    Mooradian, A.D.2
  • 65
    • 8344262275 scopus 로고    scopus 로고
    • Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response
    • Shamovsky I., and Gershon D. Novel regulatory factors of HSF-1 activation: facts and perspectives regarding their involvement in the age-associated attenuation of the heat shock response. Mech. Ageing Dev. 125 (2004) 767-775
    • (2004) Mech. Ageing Dev. , vol.125 , pp. 767-775
    • Shamovsky, I.1    Gershon, D.2
  • 66
    • 0037169236 scopus 로고    scopus 로고
    • Aging has a complex effect on a rat model of ischemic stroke
    • Shapira S., Sapir M., Wengier A., Grauer E., and Kadar T. Aging has a complex effect on a rat model of ischemic stroke. Brain Res. 925 (2002) 148-158
    • (2002) Brain Res. , vol.925 , pp. 148-158
    • Shapira, S.1    Sapir, M.2    Wengier, A.3    Grauer, E.4    Kadar, T.5
  • 67
    • 0033975658 scopus 로고    scopus 로고
    • Immunohistochemical and neurochemical correlates of learning deficits in aged rats
    • Stemmelin J., Lazarus C., Cassel S., Kelche C., and Cassel J.C. Immunohistochemical and neurochemical correlates of learning deficits in aged rats. Neuroscience 96 (2000) 275-289
    • (2000) Neuroscience , vol.96 , pp. 275-289
    • Stemmelin, J.1    Lazarus, C.2    Cassel, S.3    Kelche, C.4    Cassel, J.C.5
  • 68
    • 0022550994 scopus 로고
    • N-Methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat
    • Stewart G.R., Price M., Olney J.W., Hartman B.K., and Cozzari C. N-Methylaspartate: an effective tool for lesioning basal forebrain cholinergic neurons of the rat. Brain Res. 369 (1986) 377-382
    • (1986) Brain Res. , vol.369 , pp. 377-382
    • Stewart, G.R.1    Price, M.2    Olney, J.W.3    Hartman, B.K.4    Cozzari, C.5
  • 69
    • 0031718663 scopus 로고    scopus 로고
    • Inflammation and glial responses in ischemic brain lesions
    • Stoll G., Jander S., and Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog. Neurobiol. 56 (1998) 149-171
    • (1998) Prog. Neurobiol. , vol.56 , pp. 149-171
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 70
    • 0029843180 scopus 로고    scopus 로고
    • Effect of age in rodent models of focal and forebrain ischemia
    • discussion 1668
    • Sutherland G.R., Dix G.A., and Auer R.N. Effect of age in rodent models of focal and forebrain ischemia. Stroke 27 (1996) 1663-1667 discussion 1668
    • (1996) Stroke , vol.27 , pp. 1663-1667
    • Sutherland, G.R.1    Dix, G.A.2    Auer, R.N.3
  • 71
    • 0037458469 scopus 로고    scopus 로고
    • Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats
    • Suzuki Y., Takagi Y., Nakamura R., Hashimoto K., and Umemura K. Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats. Brain Res. 964 (2003) 116-120
    • (2003) Brain Res. , vol.964 , pp. 116-120
    • Suzuki, Y.1    Takagi, Y.2    Nakamura, R.3    Hashimoto, K.4    Umemura, K.5
  • 72
    • 0030991993 scopus 로고    scopus 로고
    • Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity
    • Toliver-Kinsky T., Papaconstantinou J., and Perez-Polo J.R. Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity. J. Neurosci. Res. 48 (1997) 580-587
    • (1997) J. Neurosci. Res. , vol.48 , pp. 580-587
    • Toliver-Kinsky, T.1    Papaconstantinou, J.2    Perez-Polo, J.R.3
  • 73
    • 20344394152 scopus 로고    scopus 로고
    • Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning
    • Trendelenburg G., and Dirnagl U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 50 (2005) 307-320
    • (2005) Glia , vol.50 , pp. 307-320
    • Trendelenburg, G.1    Dirnagl, U.2
  • 74
    • 0038809831 scopus 로고    scopus 로고
    • Advances in ischemic stroke epidemiology
    • Truelsen T., and Bonita R. Advances in ischemic stroke epidemiology. Adv. Neurol. 92 (2003) 1-12
    • (2003) Adv. Neurol. , vol.92 , pp. 1-12
    • Truelsen, T.1    Bonita, R.2
  • 75
    • 0032190996 scopus 로고    scopus 로고
    • Glial reaction in aging and Alzheimer's disease
    • Unger J.W. Glial reaction in aging and Alzheimer's disease. Microsc. Res. Tech. 43 (1998) 24-28
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 24-28
    • Unger, J.W.1
  • 76
    • 0034858859 scopus 로고    scopus 로고
    • Heat shock response and ageing: mechanisms and applications
    • Verbeke P., Fonager J., Clark B.F., and Rattan S.I. Heat shock response and ageing: mechanisms and applications. Cell Biol. Int. 25 (2001) 845-857
    • (2001) Cell Biol. Int. , vol.25 , pp. 845-857
    • Verbeke, P.1    Fonager, J.2    Clark, B.F.3    Rattan, S.I.4
  • 77
    • 0037210863 scopus 로고    scopus 로고
    • Effect of age in rats following middle cerebral artery occlusion
    • Wang R.Y., Wang P.S., and Yang Y.R. Effect of age in rats following middle cerebral artery occlusion. Gerontology 49 (2003) 27-32
    • (2003) Gerontology , vol.49 , pp. 27-32
    • Wang, R.Y.1    Wang, P.S.2    Yang, Y.R.3
  • 78
    • 0026732936 scopus 로고
    • Factors influencing long-term survival and disability among three-month stroke survivors
    • Woo J., Kay R., Yuen Y.K., and Nicholls M.G. Factors influencing long-term survival and disability among three-month stroke survivors. Neuroepidemiology 11 (1992) 143-150
    • (1992) Neuroepidemiology , vol.11 , pp. 143-150
    • Woo, J.1    Kay, R.2    Yuen, Y.K.3    Nicholls, M.G.4
  • 79
    • 0032191831 scopus 로고    scopus 로고
    • Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging
    • Yamada K., and Nabeshima T. Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging. Microsc. Res. Tech. 43 (1998) 68-74
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 68-74
    • Yamada, K.1    Nabeshima, T.2
  • 80
    • 0034054501 scopus 로고    scopus 로고
    • Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain
    • Yurek D.M., and Fletcher-Turner A. Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain. Exp. Neurol. 161 (2000) 392-396
    • (2000) Exp. Neurol. , vol.161 , pp. 392-396
    • Yurek, D.M.1    Fletcher-Turner, A.2
  • 81
    • 0035830696 scopus 로고    scopus 로고
    • Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion
    • Yurek D.M., and Fletcher-Turner A. Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion. Brain Res. 891 (2001) 228-235
    • (2001) Brain Res. , vol.891 , pp. 228-235
    • Yurek, D.M.1    Fletcher-Turner, A.2


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