Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering

Journal of Molecular Biology

Volumn 384, Issue 5, 2008, Pages 1400-1407

  Pelat, Thibaut ^a   Bedouelle, Hugues ^b   Rees, Anthony R ^c   Crennell, Susan J ^c   Lefranc, Marie Paule ^d   Thullier, Philippe ^a  

^a CENTRE DE RECHERCHES   (France)

^b INSTITUT PASTEUR   (France)

^c University of Bath   (United Kingdom)

^d UMR 9002 CNRS UM   (France)

Author keywords

antibody; germline genes; humanization; non human primate; tri dimensional modeling

Indexed keywords

ANTHRAX TOXIN; HU ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN M ANTIBODY; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ARTICLE; CONTROLLED STUDY; GERM LINE; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

PRIMATES;

EID: 56949105189     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.10.033     Document Type: Article

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