Effects of humanization by variable domain resurfacing on the antiviral activity of a single-chain antibody against respiratory syncytial virus

Protein Engineering

Volumn 12, Issue 4, 1999, Pages 357-362

  Delagrave, Simon ^a   Catalan, John ^a   Sweet, Charles ^a   Drabik, Glenn ^a   Henry, Andrew ^b   Rees, Anthony ^c,d   Monath, Thomas P ^a   Guirakhoo, Farshad ^a  

^a Acambis   (United States)

^b Hercules Incorporated   (United States)

^c OXFORD LASERS LTD   (United Kingdom)

^d UNIVERSITY OF BATH   (United Kingdom)

Author keywords

Antibody; Immunotherapy; Resurfacing; Single chain Fv

Indexed keywords

AMINO ACID; ANTIBODY; GLYCOPROTEIN; IMMUNOGLOBULIN A; VIRUS ANTIGEN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE MUTATION; HUMAN; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SURFACE PLASMON RESONANCE; VIRUS INFECTION; VIRUS NEUTRALIZATION;

ANIMALIA; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS; RNA VIRUSES; SYNCYTIAL VIRUS;

EID: 0032952032     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/12.4.357     Document Type: Article

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