Analyzing the "Degree of Humanness" of Antibody Sequences

Journal of Molecular Biology

Volumn 369, Issue 3, 2007, Pages 852-862

  Abhinandan, K R ^a   Martin, Andrew C R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

anti antibody response; antibody humanization; chimeric antibodies; HAMA response; sequence analysis

Indexed keywords

ADALIMUMAB; ALEMTUZUMAB; CHIMERIC ANTIBODY; DACLIZUMAB; INFLIXIMAB; OMALIZUMAB; PALIVIZUMAB; RITUXIMAB; TRASTUZUMAB;

ANTIBODY ENGINEERING; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS;

EID: 34248170673     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.02.100     Document Type: Article

References (32)

1. Glennie M.J., and Johnson P.W. Clinical trials of antibody therapy. Immun. Today 21 (2000) 403-410
2. Dyer M.J., Hale G., Hayhoe F.G., and Waldmann H. Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype. Blood 73 (1989) 1431-1439
3. Clark M., Cobbold S., Hale G., and Waldmann H. Advantages of rat monoclonal antibodies. Immun. Today 4 (1983) 100-101
4. Schroff R.W., Foon K.A., Beatty S.M., Oldham R.K., and Morgan A.C. Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res. 45 (1985) 879-885
5. Shawler D.L., Bartholomew R.M., Smith L.M., and Dillman R.O. Human immune response to multiple injections of murine monoclonal IgG. J. Immunol. 135 (1985) 1530-1535
6. Hwang W.Y.K., and Foote J. Immunogenicity of engineered antibodies. Methods 36 (2005) 3-10
7. Winter G., Griffiths A.D., Hawkins R.E., and Hoogenboom H.R. Making antibodies by phage display technology. Annu. Rev. Immunol. 12 (1994) 433-455
8. Low N.M., Holliger P.H., and Winter G. Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. J. Mol. Biol. 260 (1996) 359-368
9. Brüggemann M., Spicer C., Buluwela L., Rosewell I., Barton S., Surani M.A., and Rabbitts T.H. Human antibody production in transgenic mice upper case: expression from 100 kb of the human IgH locus. Eur. J. Immunol. 21 (1991) 1323-1326
10. Mendez M.J., Green L.L., Corvalan J.R., Jia X.C., Maynard-Currie C.E., Yang X.D., et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nature: Genetics 15 (1997) 146-156
11. Vaughan T.J., Osbourn J.K., and Tempest P.R. Human antibodies by design. Nature: Biotech. 16 (1998) 535-539
12. Neuberger M.S., Williams G.T., and Fox R.O. Recombinant antibodies possessing novel effector functions. Nature (London) 312 (1984) 604-608
13. Boulianne G.L., Hozumi N., and Shulman M.J. Production of functional chimaeric mouse/human antibody. Nature (London) 312 (1984) 643-646
14. Jones P.T., Dear P.H., Foote J., Neuberger M.S., and Winter G. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature (London) 321 (1986) 522-525
15. Riechmann L., Clark M., Waldmann H., and Winter G. Reshaping human antibodies for therapy. Nature (London) 332 (1988) 323-327
16. Roguska M.A., Pedersen J.T., Keddy C.A., Henry A.H., Searle S.J., Lambert J.M., et al. Humanization of murine monoclonal antibodies through variable domain resurfacing. Proc. Natl Acad. Sci. USA 91 (1994) 969-973
17. Clark M. Antibody humanization: a case of the 'Emperor's new clothes'?. Immun. Today 21 (2000) 397-402
18. Routledge E.G., Gorman S.D., and Clark M. Reshaping antibodies for therapy. In: Clark M. (Ed). Protein Engineering of Antibody Molecules for Prophylactic and Therapeutic Applications in Man (1993), Academic Titles 13-44. http://www.path.cam.ac.uk/~mrc7/reshaping/ (Available online in modified form at http://www.path.cam.ac.uk/~mrc7/reshaping/)
19. Reichert J.M. Monoclonal antibodies in the clinic. Nature: Biotech. 19 (2001) 819-822
20. Pearson W.R., and Lipman D.J. Improved tools for biological sequence comparison. Proc. Natl Acad. Sci. USA 85 (1988) 2444-2448
21. Yazaki P.J., Sherman M.A., Shively J.E., Ikle D., Williams L.E., Wong J.Y.C., et al. Humanization of the anti-CEA T84.66 antibody based on crystal structure data. Protein Eng. Des. Sel. 17 (2004) 481-489
22. O'Connor S.J., Meng Y.G., Rezaie A.R., and Presta L.G. Humanization of an antibody against human protein C and calcium-dependence involving framework residues. Protein Eng. 11 (1998) 321-328
23. Hwang W.Y.K., Almagro J.C., Buss T.N., Tan P., and Foote J. Use of human germline genes in a CDR homology-based approach to antibody humanization. Methods 36 (2005) 35-42
24. Macias A., Arce S., Leon J., Mustelier G., Bombino G., Domarco A., et al. Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg). Hybridoma 18 (1999) 263-272
25. Hopkin M. Can super-antibody drugs be tamed?. Nature (London) 440 (2006) 855-856
26. Rammensee H., Bachmann J., Emmerich N.P., Bachor O.A., and Stevanoviæ S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50 (1999) 213-219
27. Queen C., Schneider W.P., Selick H.E., Payne P.W., Landolfi N.F., Duncan J.F., et al. A humanized antibody that binds to the interleukin 2 receptor. Proc. Natl Acad. Sci. USA 86 (1989) 10029-10033
28. Carter P., Presta L., Gorman C.M., Ridgway J.B., Henner D., Wong W.L., et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc. Natl Acad. Sci. USA 89 (1992) 4285-4289
29. Kolbinger F., Saldanha J., Hardman N., and Bendig M.M. Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. Protein Eng. 6 (1993) 971-980
30. Sato K., Tsuchiya M., Saldanha J., Koishihara Y., Ohsugi Y., Kishimoto T., and Bendig M.M. Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions. Mol. Immunol. 31 (1994) 371-381
31. Johnson G., and Wu T.T. Kabat database and its applications: future directions. Nuc. Ac. Res. 29 (2001) 205-206
32. Martin A.C. Accessing the Kabat antibody sequence database by computer. Proteins: Struct. Funct. Genet. 25 (1996) 130-133