Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops

Journal of Molecular Biology

Volumn 378, Issue 5, 2008, Pages 1094-1103

  Laffly, Emmanuelle ^a   Pelat, Thibaut ^a   Cédrone, Frédéric ^b   Blésa, Stéphane ^b   Bedouelle, Hugues ^c   Thullier, Philippe ^a  

^a CENTRE DE RECHERCHES   (France)

^b Biométhodes SA   (France)

^c INSTITUT PASTEUR   (France)

Author keywords

affinity; antibody; Bacillus anthracis; enhancement; phage display

Indexed keywords

ANTHRAX TOXIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MUTANT PROTEIN; NEUTRALIZING ANTIBODY;

ANTIBODY AFFINITY; ARTICLE; CONTROLLED STUDY; ELUTION; GENE FREQUENCY; GENE LIBRARY; GENE LOCATION; GENE MUTATION; GENE TARGETING; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; GENETIC VARIABILITY; IN VITRO STUDY; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROMOTER REGION;

BACILLUS ANTHRACIS;

EID: 43049101038     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.03.045     Document Type: Article

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