Use of human germline genes in a CDR homology-based approach to antibody humanization

Methods

Volumn 36, Issue 1, 2005, Pages 35-42

  Hwang, William Ying Khee ^a,b   Almagro, Juan Carlos ^a,c   Buss, Timothy N ^a,d   Tan, Philip ^a,e   Foote, Jefferson ^a,f  

^a Fred Hutchinson Cancer Research Center   (United States)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^d SIDNEY KIMMEL CANCER CENTER   (United States)

^e Trubion Pharmaceuticals   (United States)

^f Arrowsmith Technologies   (United States)

Author keywords

Germline immunoglobulin; Humanized antibody; Immunogenicity; Superhumanization

Indexed keywords

ANTIBODY; LYSOZYME; LYSOZYME ANTIBODY D1.3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANTIBODY ENGINEERING; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; ESCHERICHIA COLI; GENE EXPRESSION; GENE STRUCTURE; GENETIC CODE; HEAVY CHAIN; HUMAN; HUMAN GENOME; IMMUNOGENICITY; LIGHT CHAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SCORING SYSTEM; SEQUENCE HOMOLOGY;

EID: 17644422139     PISSN: 10462023     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymeth.2005.01.004     Document Type: Article

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