Penicillin acylase-catalyzed synthesis of ampicillin in 'aqueous solution-precipitate' systems. High substrate concentration and supersaturation effect

Journal of Molecular Catalysis - B Enzymatic

Volumn 10, Issue 5, 2000, Pages 509-515

  Youshko, Maxim I ^a   Van Langen, Luuk M ^b   De Vroom, Erik ^c   Moody, Harold M ^d   Van Rantwijk, Fred ^b   Sheldon, Roger A ^b   Švedas, Vytas K ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c DSM RESOLVE   (Netherlands)

^d DSM RESEARCH   (Netherlands)

Author keywords

Ampicillin synthesis; Aqueous solution precipitate; Penicillin acylase; Supersaturation

Indexed keywords

ACYLATION; BIOSYNTHESIS; CATALYSIS; COMPOSITION EFFECTS; ESTERS; PRECIPITATION (CHEMICAL); SOLUBILITY; SUBSTRATES; SUPERSATURATION;

PENICILLIN ACYLASE;

ENZYMES;

6 AMINOPENICILLANIC ACID; AMIDASE; AMPICILLIN; PENICILLIN DERIVATIVE; PHENYLGLYCINE;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; SOLUBILITY;

EID: 0034597401     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1381-1177(00)00091-6     Document Type: Article

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