Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation

British Journal of Pharmacology

Volumn 118, Issue 5, 1996, Pages 1285-1293

  Patrignani, Paola ^a   Santini, Giovanna ^a   Panara, Maria R ^a   Sciulli, Maria G ^a   Greco, Anita ^a   Rotondo, Maria T ^a   Di Giamberardino, Maria ^a   Maclouf, Jacques ^c   Ciabattoni, Giovanni ^b   Patrono, Carlo ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c HÔPITAL LARIBOISIÈRE   (France)

Author keywords

8 epi PGF(2 ); Dexamethasone; Human blood monocytes; L 745,337; PGE2; Prostaglandin endoperoxide synthases

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ACETYLSALICYLIC ACID; CYCLOHEXIMIDE; DEXAMETHASONE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; ENZYME INDUCTION; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RADIOIMMUNOASSAY;

EID: 8944240838     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15535.x     Document Type: Article

References (46)

1. 2 receptors. J. Pharmacol. Exp. Ther., 270, 446-452.
2. 2α, in rabbit lung in situ. Am.J. Physiol., 263, H660-H663.
3. BOYUM, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Clin. Lab. Invest., 97, 77-89.
4. CHAN, C.-C., GORDON, R., BRIDEAU, C., RODGER, I.W., LI, C.-S., PRASIT, P., TAGARI, P., ETHIER, D., VICKERS, P., BOYCE, S., RUPNIAK, N., WEBB, J., HILL, R. & FORD-HUTCHINSON, A.W. (1994). In vivo pharmacology of L-745,337: a novel non-steroidal antiinflammatory agent (NSAID) with an ulcerogenic sparing effect in rat and monkey stomach. Can. J. Physiol. Pharmucol., 72 (Suppl.1), 266 (abstract)
5. CIABATTONI, G., PATRONO, C., VAN KOOTEN, F. & KOUDSTAAL, P.J. (1995). Dissociation of platelet activation and lipid peroxidation in acute ischemic stroke. J. Investig. Med., 43, 292A.
6. 2α in human urine. J. Endocrinol. Invest., 2, 173-182.
7. 2α via the corresponding endoperoxide by a biomimetic cyclization. Tetrahedron Lett., 25, 5013-5016.
8. DE LEAN, A., MUNSON, P.J. & RODBARD, D. (1978). Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol., 235, E97-E102.
9. DEWITT, D.L. (1991). Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim. Biophys. Acta, 1083, 121-134.
10. FLOWER, R.J. (1988). Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br. J. Pharmacol., 94, 987-1015.
11. 2-isoprostane receptors on rat vascular smooth muscle cells. Am. J. Physiol., 264, C1619-C1624.
12. FUNK, C.D., FUNK, L.B., KENNEDY, M.E., PONG, A.S. & FITZGERALD, G.A. (1991). Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J., 5, 2304-2312.
13. HABIB, A., CRÉMINON, C., FROBERT, Y., GRASSI, J., PRADELLES, P. & MACLOUF, J. (1993). Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem., 268, 23448-23454.
14. HALLIWELL, B. & GROOTVELD, M. (1987). The measurement of free radical reactions in humans. Some thoughts for future experimentation. FEBS Lett., 213, 9-14.
15. HECKER, M., ULLRICH, V., FISCHER, C. & MEESE, C.O. (1987). Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase. Eur. J. Biochem., 169, 113-123.
16. HEMPEL, S.L., MOMIK, M.M. & HUNNINGHAKE, G.W. (1994). Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J. Clin. Invest., 93, 391-396.
17. HLA, T. & NEILSON, K. (1992). Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. U.S.A., 89, 7384-7388.
18. JONES, D.A., CARLTON, D.P., MCINTYRE, T.M., ZIMMERMAN, G.A. & PRESCOTT, S.M. (1993). Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines. J. Biol. Chem., 268, 9049-9054.
19. KUJUBU, D.A. & HERSCHMAN, H.R. (1992). Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J. Biol. Chem., 267, 7991-7994.
20. LEE, S.H., SOYOOLA, E., CHANMUGAM, P., HART, S., SUN, W., ZHONG, H., LIOU, S., SIMMONS, D. & HWANG, D. (1992). Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J. Biol. Chem., 267, 25934-25938.
21. MASFERRER, J.L., ZWEIFEL, B.S., MANNING, P.T., HAUSER, S.D., LEAHY, K.M., SMITH, W.G., ISAKSON, P.C. & SEIBERT, K. (1994). Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. U.S.A., 91, 3228-3232.
22. MORITA, I., SCHINDLER, M., REGIER, M.K., OTTO, J.C., HORI, T., DEWITT, D.L. & SMITH, W.L. (1995). Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem., 270, 10902-10908.
23. 2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. U.S.A., 89, 10721-10725.
24. 2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N. Engl. J. Med., 332, 1198-1203.
25. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc. Natl. Acad. Sci. U.S.A., 87, 9383-9387.
26. 2α, is formed in vivo. Biochim. Biophys. Acta, 1210, 244-248.
27. MORROW, J.D., MINTON, T.A., MUKUNDAN, C.R., CAMPBELL, M.D., ZACKERT, W.E., DANIEL, V.C., BADR, K.F., BLAIR, I.A. & ROBERTS II, L.J. (1994b). Free-radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J. Biol. Chem., 269, 4317-4326.
28. 2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist. Prostaglandins, 44, 155-163.
29. O'BANION, M.K., WINN, V.D. & YOUNG, D.A. (1992). cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A., 89, 4888-4892.
30. O'SULLIVAN, M.G., HUGGINS JR, E.M., MEADE, E.A., DEWITT, D.L. & McCALL, C.E. (1992). Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. Biochem. Biophys. Res. Commun., 187, 1123-1127.
31. PANARA, M.R., GRECO, A., SANTINI, G., SCIULLI, M.G., ROTONDO, M.T., PADOVANO, R., DI GIAMBERARDINO, M., CIPOLLONE, F., CUCCURULLO F, PATRONO C. & PATRIGNANI, P. (1995). Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl]methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indanone (L-745,337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases. Br. J. Pharmacol., 116, 2429-2434.
32. PATRIGNANI, P., PANARA, M.R., GRECO, A., FUSCO, O., NATOLI, C., IACOBELLI, S., CIPOLLONE, F., GANCI, A., CRÉMINON, C., MACLOUF, J. & PATRONO, C. (1994). Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J. Pharmacol. Exp. Ther., 271, 1705-1712.
33. PATRIGNANI, P., PANARA, M.R., CIPOLLONE, F., GRECO, A., CIABATTONI, G. & PATRONO, C. (1995). Induction of prostaglandin endoperoxide synthase 2 in monocytes of human whole blood is associated with cyclooxygenase-dependent isoprostane formation. J. Investig. Med., 43, 335A.
34. 2 production in healthy subjects. Thromb. Res., 17, 317-327.
35. 2α. Ann. N.Y. Acad. Sci., 744, 139-145.
36. 2α. J. Biol. Chem., 270, 9800-9808.
37. REDDY, S.T. & HERSCHMAN, H.R. (1994). Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J. Biol. Chem., 269, 15473-15480.
38. ROSS, R. (1986). The pathogenesis of atherosclerosis. An update. N. Engl. J. Med., 314, 488-500.
39. ROTH, G.J., STANFORD, N. & MAJERUS, P.W. (1975). Acetylation of prostaglandin synthase by aspirin. Proc. Natl. Acad. Sci. U.S.A., 72, 3073-3076.
40. SEIBERT, K., ZHANG, V., LEAHY, K., HAUSER, S., MASFERRER, J., PERKINS, W., LEE, L. & ISAKSON, P. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. U.S.A., 91, 12013-12017.
41. SMITH, W.L. & DEWITT, D.L. (1995). Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs. Semin. Nephrol., 15, 179-194.
42. 2 receptors. J. Clin. Invest., 90, 136-141.
43. TOWBIN, H., STAEHELIN, T. & GORDON, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A., 76, 4350-4354.
44. VAN KOOTEN, F., CIABATTONI, G., PATRONO, C., SCHMITZ, P.I.M., VAN GIJN, J. & KOUDSTAAL, P.J. (1994). Evidence for episodic platelet activation in acute ischemic stroke. Stroke, 25, 278-281.
45. 2α, excretion in man. J. Pharmacol. Exp. Ther., 275, 94-100.
46. 2 receptors in human platelets. J. Pharmacol. Exp. Ther., 270, 1192-1196.