1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline

Neurochemistry International

Volumn 53, Issue 6-8, 2008, Pages 283-288

  Chetsawang, Banthit ^a,b   Kooncumchoo, Patcharee ^a,b   Govitrapong, Piyarat ^a,c   Ebadi, Manuchair ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

c Jun phosphorylation; DFF45; MPP+; Oxidative stress; Selegiline; SK N SH cells

Indexed keywords

1 METHYL 4 PHENYL PYRIDINIUM; PYRIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SELEGILINE; SERINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NEUROBLASTOMA CELL; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-METHYL-4-PHENYLPYRIDINIUM; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HERBICIDES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEINS; PROTO-ONCOGENE PROTEINS C-JUN; REACTIVE OXYGEN SPECIES; SELEGILINE; SERINE; SIGNAL TRANSDUCTION;

EID: 56649103697     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.08.007     Document Type: Article

References (48)

1. Andoh T., Chock P.B., Murphy D.L., and Chiueh C.C. Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl. Mol. Pharmacol. 68 (2005) 1408-1414
2. Behrens A., Sibilia M., and Wagner E.F. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21 (1999) 326-329
3. Brugg B., Michel P.P., Agid Y., and Ruberg M. Ceramide induces apoptosis in cultured mesencephalic neurons. J. Neurochem. 66 (1996) 733-739
4. Burke R.E. Programmed cell death and Parkinson's disease. Mov. Disord. 13 (1998) 17-23
5. Chiba K., Trevor A., and Castagnoli Jr. N. Metabolism of the neurotoxicity tertiary amine, MPTP, by brain monoamine oxidase. Biochem. Biophys. Res. Commun. 120 (1984) 457-478
6. +-induced dopaminergic neuronal cell death: role of caspases, ROS and JNK. J. Neurosci. Res. 57 (1999) 86-94
7. +, oxidant and specific neurotoxicants shares the common molecular mechanism. J. Neurochem. 76 (2001) 1010-1021
8. Cohen G., Pasik B., Cohen B., Leist A., Mytilineou C., and Yahr M.D. Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys. Eur. J. Pharmacol. 106 (1985) 209-210
9. Compton M.M. A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev. 11 (1992) 105-119
10. Dunnett S.B., and Bjorklund A. Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature 399 (1999) A32-A39
11. Ebadi M., and Pfeiffer R. Parkinson's Disease. 1st edition (2005), Taylor and Francis, London, England
12. Ebadi M., Srinivasan S.K., and Baxi M. Oxidative stress and antioxidant therapy in Parkinson's disease. Prog. Neurobiol. 48 (1996) 1-19
13. Ebadi M., Govitrapong P., Sharma S., Muralikrishnan D., Shavali S., Pellett L., Schafer R., Albano C., and Eken J. Ubiquinone (coenzyme q 10) and mitochondria in oxidative stress of Parkinson's disease. Biol. Signals Recept. 10 (2001) 224-253
14. Ebadi M., Sharma S., Shavali S., and El Refaey H. Neuroprotective actions of selegiline. J. Neurosci. Res. 67 (2002) 285-289
15. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., and Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391 (1998) 43-50
16. Gearan T., Castillo O.A., and Schwarzschild M.A. The parkinsonian neurotoxin, MPP(+) induces phosphorylated c-Jun in dopaminergric neurons of mesencephalic cultures. Parkinsonism Relat. Disord. 8 (2001) 19-22
17. Hatai T., Matsuzawa A., Inoshita S., Mochida Y., Kuroda T., Sakamaki K., Kuida K., Yonehara S., Ichijo H., and Takeda K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J. Biol. Chem. 275 (2000) 26576-26581
18. Hui L.J., Chen J.S., Chai M.Q., Zhao S., and Song J.G. The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes. Cell Res. 11 (2001) 89-94
19. Kovachich G.B., and Mishra O.P. Lipid peroxidation in rat brain cortical slices as measured by the thiobarbituric acid test. J. Neurochem. 35 (1980) 1449-1452
20. Kulich S.M., and Chu C.T. Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease. J. Neurochem. 77 (2001) 1058-1066
21. Kwon Y.S., Ann H.S., Nabeshima T., Shin E.J., Kim W.K., Jhoo J.H., Jhoo W.K., Wie M.B., Kim Y.S., Jang K.J., and Kim H.C. Selegiline potentiates the effects of Egb761 in response to ischemic brain injury. Neurochem. Int. 45 (2004) 157-170
22. 2+-dependent endonucleases as an early event in castration-induced prostatic cell death. Prostate 13 (1988) 103-117
23. Langston J.W., Ballard P.A., Tetrud J.W., and Irwin I. Chronic parkinsonism in humans due to a product of meperidine analog synthesis. Science 219 (1983) 979-980
24. Liu X., Zou H., Slaughter C., and Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89 (1997) 175-184
25. Liu X., Li P., Widlak P., Zou H., Luo X., Garrard W.T., and Wang X. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 8461-8466
26. Luo Y., Umegaki H., Wang X., Abe R., and Roth G.S. Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J. Biol. Chem. 273 (1998) 3756-3764
27. Magyar K., and Szende B. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties. Neurotoxicology 25 (2004) 233-242
28. Mandavilli B.S., and Rao K.S. Accumulation of DNA damage in aging neurons occurs through a mechanism other than apoptosis. J. Neurochem. 67 (1996) 1559-1565
29. 2+-mediated endonuclease activation. Science 242 (1988) 256-259
30. Mielke K., and Herdegen T. JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog. Neurobiol. 61 (2000) 45-60
31. Mytilineou C., and Cohen G. Deprenyl protects dopamine neurons from the neurotoxic effect of 1-methyl-4-phenylpyridinium ion. J. Neurochem. 45 (1985) 1951-1953
32. Nishi K. Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Brain Res. 771 (1997) 133-141
33. Olanow C.W., and Schapira Anthony H.V. Neuroprotection in Parkinson's disease. In: Bar P.R., and Flint Beal M. (Eds). Neuroprotection in CNS Disease (1997), Marcel Dekker, Inc., New York 425-445
34. Oo T.F., Henchcliffe C., James D., and Burke R. Expression c-fos, c-jun and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra. J. Neurochem. 72 (1999) 557-564
35. Pollanen M.S., Dickenson D.W., and Bergeron C. Pathology and biology of the Lewy body. J. Neuropathol. Exp. Neurol. 52 (1993) 183-191
36. Sakahira H., Enari M., and Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391 (1998) 96-99
37. Saporito M.S., Brown E.M., Miller M.S., and Carswell S. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons in vivo. J. Pharmaco. Exp. Ther. 288 (1999) 421-427
38. Saporito M.S., Thomas B.A., and Scott R.W. MPTP activates c-Jun NH (2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo. J. Neurochem. 75 (2000) 1200-1208
39. Saravanan K.S., Sindhu K.M., Senthilkumar K.S., and Mohanakumar K.P. l-Deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochem. Int. 49 (2006) 28-40
40. +)-induced apoptosis in SK-N-SH neurons. J. Neurocytol. 32 (2003) 329-343
41. Tatton W.G., and Chalmers-Redman R.M.E. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology 47 (1996) S171-S183
42. Tatton W.G., and Greenwood C.E. Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. J. Neurosci. Res. 30 (1991) 666-672
43. Tatton W., Chalmers-Redman R.M.E., and Tatton N. Neuroprotection by deprenyl and other propargylamines: glyceraldehyde-3-phosphate dehydrogenase rather than monoamine oxidase B. J. Neural. Transm. 110 (2003) 509-515
44. Tournier C., Hess P., Yang D.D., Xu J., Turner T.K., Nimnual A., Bar-Sagi D., Jones S.N., Flavell R.A., and Davis R.J. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288 (2000) 870-874
45. +-treated MN9D cells: A mechanism of toxicity study. Neurol. Toxicol. 28 (2007) 979-987
46. Waters C.M., and Walkinshaw G. Distinct pathways for induction of apoptosis in PC 12 cells. Soc. Neurosci. Abstr. 21 (1995) 2
47. + in vivo. Eur. J. Pharmacol. 243 (1993) 241-247
48. Xia X.G., Harding T., Weller M., Bieneman A., Uney J.B., and Schulz J.B. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10433-10438