Expression of c-Jun in dopaminergic neurons of the substantia nigra in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice

Brain Research

Volumn 771, Issue 1, 1997, Pages 133-141

  Nishi, Katsunori ^a  

^a Tokyo Metropolitan Institute   (Japan)

Author keywords

1 Methy 4 phenyl 1,2,3,6 tetrahydropyridine (MPTP); Apoptosis; c Fos; c Jun; Dopaminergic neuron; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ONCOPROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AGING; ANIMALS; DOPAMINE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; NEURONS; PROTO-ONCOGENE PROTEINS C-JUN; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 0030709389     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00862-7     Document Type: Article

References (36)

1. An G., Lin T.-N., Liu J.-S., Xue J.-J., He Y.-Y., Hsu C.Y. Expression of c-fos and c-jun family genes after focal cerebral ischemia. Ann. Neurol. 33:1993;457-464.
2. Burns R.S., Chiueh C.C., Markey S.P., Ebert M.H., Jacobowitz D.M., Kopin I.J. A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA. 80:1983;4546-4550.
3. +, a metabolite of MPTP, by brain synaptosomes. Biochem. Biophys. Res. Commun. 120:1985;574-578.
4. Davis G.C., Williams A.C., Markey S.P., Ebert M.H., Caine E.D., Reichert C.M., Kopin I.J. Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res. 1:1979;176-188.
5. +-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport. Brain Res. 715:1996;1-8.
6. Dragnow M., Beilharz E., Sirimanne E., Lawlor P., Williams C., Bravo R., Gluckman P. Immediate early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Mol. Brain Res. 25:1994;19-33.
7. Dragnow M., Young D., Hughes P., MacGibbon G., Lawlor P., Singleton K., Sirimanne E., Beilharz E., Gluckman P. Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Mol. Brain Res. 18:1993;347-352.
8. Dragnow M., Preston K. The role of inducible transcription factors in apoptotic nerve cell death. Brain Res. Rev. 21:1995;1-28.
9. Duchemin A.M., Gudehithlu K.P., Neff N.H., Hadjiconstantinou M. c-fos mRNA in mouse brain after MPTP treatment. Neurochem. Int. 20:1992;281-287.
10. Estus S., Zaks W.J., Freeman R.S., Gruda M., Bravo R., Johnson E.M. Jr. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127:1994;1717-1727.
11. Gass P., Herdegen T., Bravo R., Kiessling M. Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-D-aspartate receptor antagonist MK-801. Neuroscience. 53:1993;749-758.
12. Gupta M., Gupta B.K., Thomas R., Bruemmer V., Sladek J.R., Felten D.L. Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults. Neurosci. Lett. 70:1986;326-331.
13. Hartley A., Stone J.M., Heron C., Cooper J.M., Schapira A.H.V. Complex I inhibitors induce dose-dependent apoptosis in PC 12 cells: relevance to Parkinson's disease. J. Neurochem. 63:1994;1987-1990.
14. Heikkila R.E., Hess A., Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Science. 224:1984;1451-1453.
15. Hughes P., Dragnow M. Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol. Rev. 47:1995;133-178.
16. Jenkins R., O'Shea R., Thomas K.L., Hunt S.P. c-jun expression in substantia nigra following striatal 6-hydroxydopamine lesions in the rat. Neuroscience. 53:1993;447-455.
17. Javitch J.A., D'Amato R.J., Strimatter S.M., Snyder S.H. Parkinsonism-inducing neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA. 82:1985;2173-2177.
18. Johannessen J.N., Chiueh C.C., Burns R.S., Markey S.P. Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effect. Life Sci. 36:1985;219-224.
19. Langston J.W., Bullard P., Tetrud J.W., Irwin I. Chronic parkinsonism in humans due to a product of meperidine analog synthesis. Science. 219:1983;979-980.
20. Leah J.D., Herdegen T., Bravo R. Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process. Brain Res. 566:1991;198-207.
21. Leah J.D., Herdegen T., Murashow A., Dragnow M., Bravo R. Expression of immediate-early gene proteins following axotomy and inhibition of axonal transport in the rat CNS. Neuroscience. 57:1993;53-66.
22. Mizuno Y., Sone N., Saitoh T. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of enzymes in the electron transport system in mouse brain. J. Neurochem. 48:1987;1787-1793.
23. Morgan J.I., Curran T. Stimulus transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:1991;421-451.
24. Nishi K., Kondo T., Narabayashi H. Difference in recovery patterns of striatal dopamine content, tyrosine hydroxylase activity and total biopterin content after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration; a comparison of young and older mice. Brain Res. 489:1989;157-162.
25. +) and tetrahydroisoquinoline derivatives on dopaminergic neurons in ventral mesencephalic-striatal co-culture. Neurodegeneration. 3:1994;33-42.
26. K. Nishi, Expression of Fos in MPTP-treated mouse brain, in: C. Ohye, M. Kimura, J. McKenzie (Eds.), Basal Ganglia V, Plenum Press, New York, 1996, pp. 409-414.
27. Nicklas W.J., Vyas I., Heikkila R.E. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life. Sci. 36:1985;2503-2508.
28. Ramsay R.R., Salach J.I., Dadgar J., Singer T.P. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochem. Biophys. Res. Commun. 135:1986;269-275.
29. Ricaurte G.A., Irwin I., Forno L.S., Delanney L.E., Langston J.W. Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra. Brain Res. 403:1987;43-51.
30. Senba E., Matsunaga K., Tohyama M., Noguchi K. Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway. Brain Res. Bull. 31:1993;329-344.
31. Sershen H., Mason M.F., Hashim A., Lajtha A. Effect of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on age related changes in dopamine turnover and transporter function in mouse striatum. Eur. J. Pharmacol. 113:1985;135-136.
32. R.L. Sidman, J.B. Angeuine, E.T. Pierce, Atlas of the Mouse Brain and Spinal Cord, Harvard University Press, Cambridge, 1971.
33. Sonsalla P.K., Gail D., Zeevalk G.D., Manzino L., Giovanni A., Nicklas W.J. MK801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats. J. Neurochem. 58:1992;1979-1982.
34. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature. 349:1991;414-418.
35. Walkinshaw G., Waters C.M. Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience. 63:1994;975-987.
36. Zhou F., Thompson E.B. Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts. Mol. Endocrinol. 10:1996;306-316.