Binding of the novel radioligand [3H]UFP-101 to recombinant human and native rat nociceptin/orphanin FQ receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 6, 2008, Pages 553-561

  Ibba, Massimo ^a,b   Kitayama, Masato ^a   McDonald, John ^a   Calo, Girolamo ^b   Guerrini, Remo ^b   Farkas, Judit ^c   Toth, Geza ^c   Lambert, David G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF FERRARA   (Italy)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Guanine nucleotides; Nociceptin Orphanin FQ; NOP receptor; Radiolabeled Nociceptin Orphanin FQ receptor antagonist 3H UFP 101; Radioligand binding

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NOCICEPTIN; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; NOCICEPTIN RECEPTOR ANTAGONIST; RADIOLIGAND; RECOMBINANT RECEPTOR; SODIUM; UFP 101; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; BRAIN CORTEX; CHO CELL; DRUG RECEPTOR BINDING; IC 50; LIGAND BINDING; NONHUMAN; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; OPIOID PEPTIDES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56549121275     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0350-3     Document Type: Article

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