Nociceptin (Orphanin FQ): High-affinity and high-capacity binding site coupled to low-potency stimulation of guanylyl-5'-O-(γ,-thio)-triphosphate binding in rat brain membranes

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 2, 1998, Pages 896-902

  Albrecht, Erika ^a   Samovilova, Nelya N ^b   Oswald, Stephan ^a   Baeger, Ingo ^a   Berger, Hartmut ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ENDORPHIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NOCICEPTIN; NOCICEPTIN[1-13]; NOCICEPTIN[1-17][7 DEXTRO ALANINE]; NOCICEPTIN[1-9]; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PUTAMEN; RAT; RECEPTOR AFFINITY;

ANALGESICS, OPIOID; ANIMALS; BRAIN CHEMISTRY; BUFFERS; CEREBRAL CORTEX; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; MALE; MEMBRANES; OPIOID PEPTIDES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, OPIOID; SPINAL CORD;

EID: 0032411216     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Albrecht E, Heinrich N, Lorenz D, Baeger I, Samovilova N, Fechner K and Berger H (1997) Influence of continuous levels of fentanyl in rats on the mu-opioid receptor in the central nervous system. Pharm Biochem Behav 58:189-194.
2. Anton B, Fein J, To T, Li X, Silberstein L and Evans CJ (1996) Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J Comp Neurol 368:229-251.
3. Ardati A, Henningsen RA, Higelin J, Reinscheid RK, Civelli O and Monsma FJ (1997) Interaction of [H-3]orphanin FQ and I-125-Tyr14-orphanin FQ with the orphanin FQ receptor: Kinetics and modulation by cations and guanine nucleotides. Mol Pharmacol 51:816-824.
4. Butour JL, Moisand C, Mazarguil H, Mollereau C and Meunier JC (1997) Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids. Eur J Pharmacol 321:97-103.
5. Dooley CT and Houghten RA (1996) Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain. Life Sci 59:PL23-PL29.
6. Fukuda K, Shoda T, Morikawa H, Kato S and Mori K (1997) Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells. FEBS Lett 412:290-294.
7. Gudermann T, Kalkbrenner F and Schultz G (1996) Diversity and selectivity of receptor-G protein interaction. Annu Rev Pharmacol Toxicol 36:429-459.
8. Henderson G and Mcknight AT (1997) The orphan opioid receptor and its endogenous ligand- nociceptin/orphanin FQ. Trends Pharmacol Sci 18:293-300.
9. Lachowicz JE, Shen Y, Monsma FJ and Sibley DR (1995) Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J Neurochem 64:34-40.
10. Ma L, Cheng ZJ, Fan GH, Cai YC, Jiang LZ and Pei G (1997) Functional expression, activation and desensitization of opioid receptorlike receptor ORL(1) in neuroblastoma x glioma NG108-15 hybrid cells. FEBS Lett 403:91-94.
11. Makman MH, Lyman WD and Dvorkin B (1997) Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus. Brain Res 762:247-250.
12. Mathis JP, Ryanmoro J, Chang A, Hom JSH, Scheinberg DA and Pasternak GW (1997) Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochem Biophys Res Commun 230:462-465.
13. Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, Mazarguil H, Vassart G, Parmentier M and Costentin J (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL(1) receptor. Nature 377:532-535.
14. Mogil JS, Grisel JE, Zhangs G, Belknap JK and Grandy DK (1996) Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ. Neurosci Lett 214:131-134.
15. Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G and Meunier JC (1994) Orl1, a novel member of the opioid receptor family - cloning, functional expression and localization. FEBS Lett 341:33-38.
16. Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ and Civelli O (1995) Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270:792-794.
17. Reinscheid RK, Ardati A, Monsma FJ and Civelli O (1996) Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J Biol Chem 271:14163-14168.
18. Rossi GC, Leventhal L and Pasternak GW (1996) Naloxone sensitive orphanin FQ-induced analgesia in mice. Eur J Pharmacol 311:R7-R8.
19. Rossi GC, Leventhal L, Bolan E and Pasternak GW (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J Pharmacol Exp Ther 282:858-865.
20. Shimohigashi Y, Hatano R, Fujita T, Nakashima R, Nose T, Sujaku T, Saigo A, Shinjo K and Nagahisa A (1996) Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide. J Biol Chem 271:23642-23645.
21. Sim LJ, Selley DE and Childers SR (1995 In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5′-[gamma-[S-35]thio]triphosphate binding. Proc Natl Acad Sci USA 92:7242-7246, 1995.
22. Sim LJ, Xiao RY and Childers SR (1996a) Identification of opioid receptor-like (ORL1) peptide- stimulated [S-35]GTP gamma S binding in rat brain. Neuroreport 7:729-733.
23. Sim LJ, Selley DE, Xiao RY and Childers SR (1996b) Differences in G-protein activation by mu- and delta-opioid, and cannabinoid, receptors in rat striatum. Eur J Pharmacol 307:97-105.
24. Tian JH, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK and Han JS (1997) Bidirectional modulatory effect of orphanin FQ on morphine- induced analgesia: Antagonism in brain and potentiation in spinal cord of the rat. Br J Pharmacol 120:676-680.
25. Werling LL, Puttfarcken PS and Cox BM (1988) Multiple agonist-affinity states of opioid receptors: Regulation of binding by guanyl nucleotides in guinea pig cortical, NG 103-15, and 7315c cell membranes. Mol Pharmacol 33:423-431.
26. Wieland T and Jakobs KH (1994) Measurement of receptor-stimulated guanosine 5-O-(gamma-thio)triphosphate binding by G proteins. Methods Enzymol 237:3-13.
27. Wong CS, Su YF, Watkins WD and Chang KJ (1994) Opioid agonist binding affinity is increased by magnesium in the presence of guanosine diphosphate but decreased by magnesium in the presence of guanyl-5′-Yl imidodiphosphate. J Pharmacol Exp Ther 268:653-661.