Sodium ions and GTP decrease the potency of [Nphe1]N/OFQ(1-13)NH2 in blocking nociceptin/orphanin FQ receptors coupled to cyclic AMP in N1E-115 neuroblastoma cells and rat olfactory bulb

Life Sciences

Volumn 72, Issue 25, 2003, Pages 2905-2914

  Olianas, Maria C ^a   Onali, Pierluigi ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

CompB; Cyclic AMP; GTP; N1E 115 neuroblastoma cells; Nociceptin orphanin FQ; Olfactory bulb; Sodium ions; Nphe1 nociceptin orphaninFQ(1 13)NH2

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ADENYLATE CYCLASE; BENZIMIDAZOLE DERIVATIVE; CYCLIC AMP; GUANOSINE TRIPHOSPHATE; NOCICEPTIN RECEPTOR; PSEUDOPEPTIDE; SODIUM ION;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL MEMBRANE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; MOUSE; NEUROBLASTOMA; NONHUMAN; OLFACTORY BULB; RECEPTOR BLOCKING;

EID: 0037427366     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00193-0     Document Type: Article

References (28)

1. Adapa I.D., Toll L. Relationship between binding affinity and functional activity of nociceptin/orphanin FQ. Neuropeptides. 31:1997;403-408.
2. 125I-Tyr14-orphanin FQ with the orphanin FQ receptor: kinetic and modulation by cations and guanine nucleotides. Molecular Pharmacology. 51:1997;816-824.
3. Arunlakshana O., Schild H.O. Some quantitative uses of drug antagonists. British Journal of Pharmacology. 14:1959;48-58.
4. 2 selectively antagonizes nociceptin/orphanin FQ-stimulated G-protein activation in rat brain. Journal of Pharmacology and Experimental Therapeutics. 294:2000;428-433.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 72:1976;248-254.
6. Burgisser E., De Lean A., Lefkowitz R.J. Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. Proceedings of National Academy of Science USA. 79:1982;1732-1736.
7. 2 is an agonist of the nociceptin (ORL1) receptor. European Journal of Pharmacology. 349:1998;R5-R6.
8. 2, a new selective nociceptin receptor antagonist. British Journal of Pharmacology. 129:2000;1183-1193.
9. Calo' G., Guerrini R., Rizzi A., Salvadori S., Regoli D. Pharmacology of nociceptin and its receptor: a novel therapeutic target. British Journal of Pharmacology. 129:2000;1261-1283.
10. Calo' G., Bigoni R., Rizzi A., Guerrini R., Salvadori S., Regoli D. Nociceptin/orphanin FQ receptor ligands. Peptides. 21:2000;935-947.
11. Ehlert F., Roeske W.R., Yamamura H.I. Muscarinic receptor: regulation by guanine nucleotides, ions and N-ethylmaleimide. Federation Proceedings. 40:1981;153-159.
12. Guerrini R., Calo' G., Rizzi A., Bigoni R., Bianchi C., Salvadori S., Regoli D. A new selective antagonist of the nociceptin receptor. British Journal of Pharmacology. 123:1998;163-165.
13. Guerrini R., Calo' G., Bigoni R., Rizzi A., Varani K., Toth G., Gessi S., Hashiba E., Hashimoto Y., Lambert D.G., Borea P.A., Tomatis R., Salvadori S., Regoli D. Further studies on nociceptin-related peptides: discovery of new chemical template with antagonistic activity on the nociceptin receptor. Journal of Medicinal Chemistry. 43:2000;2805-2813.
14. 2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor. Neuroscience Letters. 278:2000;109-112.
15. Horstman D.A., Brandon S., Wilson A.L., Guyer C.A., Cragoe E.J. Jr., Limbird L.E. An aspartate conserved among G-protein receptors confers allosteric regulation of α2-adrenergic receptors by sodium. The Journal of Biological Chemistry. 265:1990;21590-21595.
16. Kong H., Raynor K., Yasuda K., Moe S.T., Portoghese P.S., Bell G.I., Reisine T. A single residue, aspartic acid 95, in the δ opioid receptor specifies selective high affinity agonist binding. The Journal of Biological Chemistry. 268:1993;23055-23058.
17. Mathis J.P., Ryan-Moro J., Chang A., Hom J.S.H., Scheinberg D.A., Pasternak G.W. Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochemical and Biophysical Research Communications. 230:1997;462-465.
18. Meunier J.-C. The potential therapeutic value of nociceptin receptor agonists and antagonists. Expert Opinion on Therapeutic Patents. 10:2000;371-388.
19. Neve K.A., Cox B.A., Henningsen R.A., Spanoyannis A., Neve R.L. Pivotal role for aspartate-80 in the regulation of D2 receptor affinity for drugs and inhibition of adenylyl cyclase. Molecular Pharmacology. 39:1991;733-739.
20. 2 acts as a partial agonist at ORL1 receptor endogenously expressed in mouse N1E-115 neuroblastoma cells. NeuroReport. 10:1999;1127-1131.
21. 2. Proceedings of Society for Neuroscience. 26:2000;1159.
22. Olianas M.C., Onali P. Pharmacological properties of nociceptin/orphanin FQ-induced stimulation and inhibition of cyclic AMP formation in distinct layers of rat olfactory bulb. British Journal of Pharmacology. 135:2002;233-238.
23. Ozaki S., Kawamoto H., Itoh Y., Miyaji M., Iwasawa Y., Ohta H. A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397. European Journal of Pharmacology. 387:2000;R17-R18.
24. Pert C.B., Snyder S.H. Opiate receptor binding of agonist and antagonists affected differentially by sodium. Molecular Pharmacology. 10:1974;868-879.
25. Rosenberger L.B., Yamamura H.I., Roeske W.R. Cardiac muscarinic cholinergic receptor binding is regulated by Na+ and guanyl nucleotides. The Journal of Biological Chemistry. 255:1980;820-823.
26. Salomon Y., Londos D., Rodbell M. A highly sensitive adenylate cyclase assay. Analitical Biochemistry. 58:1974;541-548.
27. Tallarida R.J., Murray R.B. Manual of Pharmacologic Calculations with Computer Programs. 1987;Springer-Verlag, New York.
28. Zaveri N., Polgar W.E., Olsen C.M., Kelson A.B., Grundt P., Lewis J.W., Toll L. Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors. European Journal of Pharmacology. 428:2001;29-36.