Interaction of [3H]orphanin FQ and 125I-Tyr14-orphanin FQ with the orphanin FQ receptor: Kinetics and modulation by cations and guanine nucleotides

Molecular Pharmacology

Volumn 51, Issue 5, 1997, Pages 816-824

  Ardati, Ali ^a   Henningsen, Robert A ^a   Higelin, Jacqueline ^a   Reinscheid, Rainer K ^a   Civelli, Olivier ^a,b   Monsma Jr , Frederick J ^a,c  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHLORIDE; CATION; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; IODINE 125; MAGNESIUM CHLORIDE; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; NOCICEPTIN; ORPHANIN FQ [14 TYROSINE]; SODIUM CHLORIDE; SYNTHETIC PEPTIDE; TRITIUM; UNCLASSIFIED DRUG; ZINC CHLORIDE; NOCICEPTIN RECEPTOR; OPIATE PEPTIDE; OPIATE RECEPTOR; RADIOACTIVE IODINE;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EMBRYO; HUMAN; HUMAN CELL; ISOTOPE LABELING; KIDNEY CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RADIOIODINATION; RAT; ANIMAL; CELL LINE; CHEMISTRY; HAMSTER; KINETICS; METABOLISM; RADIOASSAY;

ANIMALS; CATIONS; CELL LINE; CHO CELLS; CRICETINAE; GUANINE NUCLEOTIDES; HUMANS; IODINE RADIOISOTOPES; KINETICS; OPIOID PEPTIDES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID; TRITIUM;

EID: 0030609875     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.5.816     Document Type: Article

References (24)

1. Bunzow, J. R., C. Saez, M. Mortrud, C. Bouvier, J. T. Williams, M. Low, and D. K. Grandy. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family, that is not a μ, δ, or a κ opioid receptor type. FEBS Lett. 347:284-288 (1994).
2. Mollereau, C., M. Parmentier, P. Mailleux, J.-L. Butour, C. Moisand, P. Chalon, D. Caput, G. Vassart, and J.-C. Meunier. ORL1, a novel member of the opioid receptor family: cloning, functional expression and localization. FEBS Lett. 341:33-38 (1994).
3. Reinscheid, R. K., H.-P. Nothacker, A. Bourson, A. Ardati, R. A. Henningsen, J. R. Bunzow, D. K. Grandy, H. Langen, F. J. Monsma, Jr., and O. Civelli. Orphanin FQ: a neuropeptide that activates an opioid like G protein-coupled receptor. Science (Washington D. C.) 270:792-794 (1995).
4. Meunier, J.-C., C. Mollereau, L. Toll, C. Suaudeau, C. Moisand, P. Alvinerie, J.-L. Butour, J.-C. Guillemot, P. Ferrara, B. Monsarrat, H. Mazaeguil, G. Vassart, M. Parmentier, and J. Costentin. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature (Lond.) 377:532-535 (1995).
5. Reinscheid, R. K., A. Ardati, F. J. Monsma, Jr., and O. Civelli. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J. Biol. Chem. 271:14163-14168 (1996).
6. Hunter, W. M., and F. C. Greenwood. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature (Lond.) 194:495-496 (1962).
7. Mc Pherson, G. A. Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J. Pharmacol. Methods 4:213-228 (1985).
8. Munson, P. J., and D. Rodbard. LIGAND: a versatile computerized approach for characterization of ligand binding systems. Anal. Biochem. 107:202-239 (1980).
9. Weiland, G. A., and P. B. Molinoff. Quantitative analysis of drug-receptor interactions: determination of kinetic and equilibrium properties. Life Sci. 29:313-330 (1981).
10. Pert, C. B., and S. Snyder. Opiate receptor binding of agonists and antagonists affected differentially by sodium. Mol. Pharmacol. 10:808-879 (1974).
11. ++ and other divalent cations on the binding of tritiated opioid ligands. J. Neurochem. 59:467-472 (1992).
12. Wong, C. S., Y.-F. Su, W. D. Watkins, and K.-J. Chand. Opioid agonist binding affinity is increased by magnesium in the presence of guanosine diphosphate but decreased by magnesium in the presence of guanyl-5′-yl imidodiphosphate. J. Pharmacol. Exp. Ther. 268:653-661 (1994).
13. Sadee, W., A. Pfeifer, and A. Herz. Opiate receptors: multiple effects of metal ions. J. Neurochem. 39:659-667 (1982).
14. Zajac, J.-M., and B. Roques. Differences in binding properties of μ and δ receptor subtypes from rat brain: kinetic analysis and effects of ions and nucleotides. J. Neurochem. 44:1605-1614 (1985).
15. 125I)β-endorphin binding to rat membranes: monovalent cation requirement. J. Neurochem. 50:1844-1850 (1988).
16. 125I]β-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements. Brain Res. 493:23-32 (1989).
17. Krumins, S. A., D. C. Kim, O. J. Igwe, and A. Larson. DAMGO binding to mouse brain membranes: influence of salts, guanine nucleotides, substance P, and substance P fragments. Peptides 14:309-314 (1993).
18. Kosterlitz, H. W., S. J. Peterson, L. E. Robson, and J. R. Traynor. Effect of cations on binding in membrane suspensions of various opioids at μ sites of rabbit cerebellum and κ sites of guinea-pig cerebellum. Br. J. Pharmacol. 91:431-437 (1987).
19. + ions and Gpp(NH)p. Eur. J. Pharmacol. 172:381-384 (1989).
20. Paterson, S. J., L. E. Robson, and H. W. Kosterlitz. Control by cations of opioid binding in guinea pig membranes. Proc. Natl. Acad. Sci. USA 83:6216-6220 (1986).
21. ++ on the formation of the ternary complex between agonist, β-adrenoceptor, and Gs-protein and interpretation of high and low affinity binding of β-adrenoceptor agonists. Pharmacol. Toxicol. 70:192-197 (1992).
22. Kong, H., K. Raynor, K. Yasuda, S. T. Moe, P. S. Portoghese, G. I. Bell, and T. Reisine. A single residue, aspartic acid 95, in the δ-opioid receptor specifies selective high affinity agonist binding. J. Biol. Chem. 266:23055-23058 (1993).
23. Stengaard-Pedersen, K. Inhibition of enkephalin binding to opiate receptors by zinc ions: possible physiological importance in the brain. Acta Pharmacol. Toxicol. 50:213-220 (1982).
24. Lachowicz, J. E., Y. Shen, F. J. Monsma, Jr., and D. R. Sibley. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J. Neurochem. 64:34-40 (1995). [/ref]