Metal ion-binding studies highlight important differences between flaviviral RNA polymerases

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1794, Issue 1, 2009, Pages 50-60

  Bougie, Isabelle ^a   Bisaillon, Martin ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Circular dichroism; Denaturation study; Fluorescence spectroscopy; Magnesium ion; West Nile virus

Indexed keywords

ASPARTIC ACID; COBALT DERIVATIVE; MAGNESIUM DERIVATIVE; MAGNESIUM ION; METAL COMPLEX; METAL ION; NONSTRUCTURAL PROTEIN 5; RNA POLYMERASE; VIRUS RNA;

ARTICLE; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENATURATION; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; FLUORESCENCE SPECTROSCOPY; METAL BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; PROTEIN PURIFICATION; THERMODYNAMICS; WEST NILE FLAVIVIRUS;

BASE SEQUENCE; BINDING SITES; CHLORIDES; CIRCULAR DICHROISM; COBALT; DNA-DIRECTED RNA POLYMERASES; FLAVIVIRUS; IONS; MAGNESIUM; METALS; MUTATION; PROTEIN DENATURATION; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS; UREA; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE VIRUS;

FLAVIVIRIDAE; WEST NILE VIRUS;

EID: 56449126887     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2008.09.009     Document Type: Article

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