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Volumn 4, Issue 10, 2004, Pages 1595-1607

Human cancer gene therapy with cytokine gene-modified cells

Author keywords

Cytokines; Gene modified cancer vaccines; Human gene therapy

Indexed keywords

ALPHA INTERFERON; CANCER VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7;

EID: 5644255720     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.4.10.1595     Document Type: Review
Times cited : (20)

References (114)
  • 1
    • 0035912764 scopus 로고    scopus 로고
    • How the immune system works to protect the host from infection: A personal view
    • JANEWAY CA JR: How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. USA (2001) 98:7461-7468.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7461-7468
    • Janeway Jr., C.A.1
  • 2
    • 0036812626 scopus 로고    scopus 로고
    • The inate immune response to tumors and its role in the induction of T-cell immunity
    • DIEFENBACH A, RAULET D: The inate immune response to tumors and its role in the induction of T-cell immunity. Immunol. Rev. (2002) 188:9-21.
    • (2002) Immunol. Rev. , vol.188 , pp. 9-21
    • Diefenbach, A.1    Raulet, D.2
  • 3
    • 0036229771 scopus 로고    scopus 로고
    • NK cells, MHC class I molecules and the missing self
    • KARRE K: NK cells, MHC class I molecules and the missing self. Scand. J. Immunol. (2002) 55:221-228.
    • (2002) Scand. J. Immunol. , vol.55 , pp. 221-228
    • Karre, K.1
  • 4
    • 3543053363 scopus 로고    scopus 로고
    • Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes
    • ALBERT ML, PEARCE SF, FRANCISCO LM et al.: Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. (1998) 188:1359-1368.
    • (1998) J. Exp. Med. , vol.188 , pp. 1359-1368
    • Albert, M.L.1    Pearce, S.F.2    Francisco, L.M.3
  • 5
    • 0035070198 scopus 로고    scopus 로고
    • CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70 and calreticulin
    • BASU S, BINDER RJ, RAMALIGNAM T, SRIVASTAVA PK: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70 and calreticulin. Immunity (2001) 14:303-313.
    • (2001) Immunity , vol.14 , pp. 303-313
    • Basu, S.1    Binder, R.J.2    Ramalignam, T.3    Srivastava, P.K.4
  • 6
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • GALLUCCI S, LOLKEMA M, MATZINGER P: Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. (1999) 11:1249-1255.
    • (1999) Nat. Med. , vol.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 7
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • GALLUCCI S, MATZINGER P: Danger signals: SOS to the immune system. Curr. Opin. Immunol. (2001) 13:114-119.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 9
    • 0032546352 scopus 로고    scopus 로고
    • Cells and the control of immunity
    • BANCHEREAU J, STEINMAN RM: cells and the control of immunity. Nature (1998) 6673:245-252.
    • (1998) Nature , vol.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 11
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • BRETSCHER P, COHN M: A theory of self-nonself discrimination. Science (1970) 169:1042-1049.
    • (1970) Science , vol.169 , pp. 1042-1049
    • Bretscher, P.1    Cohn, M.2
  • 12
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high risk resected cutaneous melanoma: ECOG trial EST 1684
    • KIRKWOOD JM, STRAWDERMAN MH, ERNSTOFF MS et al.: Interferon alfa-2b adjuvant therapy of high risk resected cutaneous melanoma: ECOG trial EST 1684. J. Clin. Oncol. (1996) 14:7-17.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 7-17
    • Kirkwood, J.M.1    Strawderman, M.H.2    Ernstoff, M.S.3
  • 13
    • 0034088027 scopus 로고    scopus 로고
    • High and low dose interferon alpha-2b in high risk melanoma. First analysis of intergroup trial E1690/S911C9190
    • KIRKWOOD JM, IBRAHIM JG, SONDAK VK et al.: High and low dose interferon alpha-2b in high risk melanoma. First analysis of intergroup trial E1690/S911C9190. J. Clin. Oncol. (2000) 18:2444-2458.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2444-2458
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sondak, V.K.3
  • 14
    • 0035339880 scopus 로고    scopus 로고
    • High dose Interferon alfa 2b significantly prolongs relapse free survival compared with GM2-KLH/QS-21 vaccine in patients with resected stage IIB-II melanoma: Results of intergroup trial E1694/S9512/C509081
    • KIRKWOOD JM, IBRAHIM JG, SOSMAN JA et al.: High dose Interferon alfa 2b significantly prolongs relapse free survival compared with GM2-KLH/QS-21 vaccine in patients with resected stage IIB-II melanoma: results of intergroup trial E1694/S9512/C509081. J. Clin. Oncol. (2001) 19:2370-2380.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3
  • 15
    • 0035883950 scopus 로고    scopus 로고
    • Effect of long term adjuvant therapy with interferon alpha 2a in patients with regional node metastases from cutaneous melanoma. A randomized trial
    • CASCINELLI N, BELLI F, MACKKIE RM et al.: Effect of long term adjuvant therapy with interferon alpha 2a in patients with regional node metastases from cutaneous melanoma. A randomized trial. Lancet (2001) 358:866-869.
    • (2001) Lancet , vol.358 , pp. 866-869
    • Cascinelli, N.1    Belli, F.2    Mackkie, R.M.3
  • 16
    • 0035805053 scopus 로고    scopus 로고
    • Adjuvant interferon alpha 2b in high risk melanoma - The Scottish Study
    • CAMERON DA, CORNBLEET MC, MACKIE RM et al.: Adjuvant interferon alpha 2b in high risk melanoma - the Scottish Study. Br. J. Cancer (2001) 84:1146-1149.
    • (2001) Br. J. Cancer , vol.84 , pp. 1146-1149
    • Cameron, D.A.1    Cornbleet, M.C.2    Mackie, R.M.3
  • 17
    • 7144228601 scopus 로고    scopus 로고
    • Randomised trial of interferon α2a as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases
    • GROB JJ, DRENO B, CHASTANG C et al.: Randomised trial of interferon α2a as adjuvant therapy in resected primary melanoma thicker than 1.5 mm without clinically detectable node metastases. Lancet (1998) 351:1905-1910.
    • (1998) Lancet , vol.351 , pp. 1905-1910
    • Grob, J.J.1    Dreno, B.2    Chastang, C.3
  • 18
    • 0037352253 scopus 로고    scopus 로고
    • Adjuvant therapy of cutaneous melanoma: The interferon debate
    • KEFFORD RF: Adjuvant therapy of cutaneous melanoma: the interferon debate. Ann. Oncol. (2003) 14:358-365.
    • (2003) Ann. Oncol. , vol.14 , pp. 358-365
    • Kefford, R.F.1
  • 19
    • 0033847587 scopus 로고    scopus 로고
    • Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
    • FISHER RI, ROSENBERG SA, FYFE G: Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J. Sci. Am. (2000) 6(Suppl. 1):S55-S57.
    • (2000) Cancer J. Sci. Am. , vol.6 , Issue.SUPPL. 1
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 20
    • 0027529476 scopus 로고
    • Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer
    • ROSENBERG SA, LOTZE MT, YANG JC et al.: Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J. Natl. Cancer Inst. (1993) 85:622-632.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 622-632
    • Rosenberg, S.A.1    Lotze, M.T.2    Yang, J.C.3
  • 21
    • 2942560498 scopus 로고    scopus 로고
    • NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome
    • ASSIER E, JULLIEN V, LEFORT J et al.: NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome. J. Immunol. (2004) 172:7661-7668.
    • (2004) J. Immunol. , vol.172 , pp. 7661-7668
    • Assier, E.1    Jullien, V.2    Lefort, J.3
  • 23
    • 0033998594 scopus 로고    scopus 로고
    • Adjuvant therapy of stage III and IV malignant melanoma using granulocyte-macrophage colony-stimulating factor
    • SPITLER LE, GROSSBARD ML, ERNSTOFF MS et al.: Adjuvant therapy of stage III and IV malignant melanoma using granulocyte-macrophage colony-stimulating factor. J. Clin. Oncol. (2000) 18:1614-1621.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1614-1621
    • Spitler, L.E.1    Grossbard, M.L.2    Ernstoff, M.S.3
  • 24
    • 0037208522 scopus 로고    scopus 로고
    • Prostate-specific antigen kinetics as a measure of the biological effect of granulocyte-macrophage colony-stimulating factor in patients with serologic progression of prostate cancer
    • RINI BI, WEINBERG V, BOK R, SMALL EJ: Prostate-specific antigen kinetics as a measure of the biological effect of granulocyte-macrophage colony-stimulating factor in patients with serologic progression of prostate cancer. J. Clin. Oncol. (2003) 21:99-105.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 99-105
    • Rini, B.I.1    Weinberg, V.2    Bok, R.3    Small, E.J.4
  • 25
    • 0032883416 scopus 로고    scopus 로고
    • Aerosol granulocyte-macrophage colony-stimulating factor: A low toxicity, lung-specific biological therapy in patients with lung metastases
    • ANDERSON PM, MARKOVIC SN, SLOAN JA et al.: Aerosol granulocyte-macrophage colony-stimulating factor: a low toxicity, lung-specific biological therapy in patients with lung metastases. Clin. Cancer Res. (1999) 5:2316-2323.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2316-2323
    • Anderson, P.M.1    Markovic, S.N.2    Sloan, J.A.3
  • 26
    • 0028824039 scopus 로고
    • IL-12 deaths: Explanation and a puzzle
    • COHEN J: IL-12 deaths: explanation and a puzzle. Science (1995) 270:908.
    • (1995) Science , vol.270 , pp. 908
    • Cohen, J.1
  • 27
    • 0030766971 scopus 로고    scopus 로고
    • Effects of single-dose interleukin-qw exposure on interleukin-12- associated toxicity and interferon-gamma production
    • LEONARD JP, SHERMAN ML, FISHER GL et al.: Effects of single-dose interleukin-qw exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood (1997) 90:2541-2548.
    • (1997) Blood , vol.90 , pp. 2541-2548
    • Leonard, J.P.1    Sherman, M.L.2    Fisher, G.L.3
  • 28
    • 0023600858 scopus 로고
    • Tumour necrosis factor in man: Clinical and biological observations
    • SELBY P, HOBBS S, VINER C et al.: Tumour necrosis factor in man: clinical and biological observations. Br. J. Cancer (1987) 56:803-808.
    • (1987) Br. J. Cancer , vol.56 , pp. 803-808
    • Selby, P.1    Hobbs, S.2    Viner, C.3
  • 29
    • 0023684531 scopus 로고
    • A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients
    • FEINBERG B, KURZROCK R, TALPAZ M, BLICK M, SAKS S, GUTTERMAN JU: A Phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients. J. Clin. Oncol. (1988) 6:1328-1334.
    • (1988) J. Clin. Oncol. , vol.6 , pp. 1328-1334
    • Feinberg, B.1    Kurzrock, R.2    Talpaz, M.3    Blick, M.4    Saks, S.5    Gutterman, J.U.6
  • 30
    • 0026531756 scopus 로고
    • High-dose recombinant tumor necrosis factor α in combination with interferon γ and melphalan in isolation perfusion of the limbs for melanoma and sarcoma
    • LIENARD D, EWALENKO P, DELMOTTE JJ, RENARD N, LEJEUNE FJ: High-dose recombinant tumor necrosis factor α in combination with interferon γ and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J. Clin. Oncol. (1992) 10:52-60.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 52-60
    • Lienard, D.1    Ewalenko, P.2    Delmotte, J.J.3    Renard, N.4    Lejeune, F.J.5
  • 31
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • DRANOFF G, JAFFE E, LAZENBY A et al.: Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA (1993) 90:3539-3543.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffe, E.2    Lazenby, A.3
  • 32
    • 0034047619 scopus 로고    scopus 로고
    • Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand
    • MACH N, GILLESSEN S, WILSON SB, SHEEHAN C, MIHM M, DRANOFF G: Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. (2000) 60:3239-3246.
    • (2000) Cancer Res. , vol.60 , pp. 3239-3246
    • Mach, N.1    Gillessen, S.2    Wilson, S.B.3    Sheehan, C.4    Mihm, M.5    Dranoff, G.6
  • 33
    • 0024988334 scopus 로고
    • Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumour-infiltrating lymphocytes modified by retroviral gene transduction
    • ROSENBERG SA, AEBERSOLD P, CORNETTA K et al.: Gene transfer into humans-immunotherapy of patients with advanced melanoma, using tumour-infiltrating lymphocytes modified by retroviral gene transduction. N. Engl. J. Med. (1990) 323:570-578.
    • (1990) N. Engl. J. Med. , vol.323 , pp. 570-578
    • Rosenberg, S.A.1    Aebersold, P.2    Cornetta, K.3
  • 34
    • 0028991828 scopus 로고
    • Protection of retroviral vector particles in human blood through complement inhibition
    • ROTHER RP, SQUINTO SP, MASON JM, ROLINS SA: Protection of retroviral vector particles in human blood through complement inhibition. Hum. Gene Ther. (1995) 6:429-435.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 429-435
    • Rother, R.P.1    Squinto, S.P.2    Mason, J.M.3    Rolins, S.A.4
  • 35
    • 0030756821 scopus 로고    scopus 로고
    • Gene therapy with recombinant adenovirus vectors: Evaluation of the host immune response
    • CHRIST M, LUSKY M, STOECKEL F et al.: Gene therapy with recombinant adenovirus vectors: evaluation of the host immune response. Immunol. Lett. (1997) 57:19-25.
    • (1997) Immunol. Lett. , vol.57 , pp. 19-25
    • Christ, M.1    Lusky, M.2    Stoeckel, F.3
  • 36
    • 0029664338 scopus 로고    scopus 로고
    • Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy
    • GORZIGLIA M, KADAN MJ, YEI S et al.: Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. (1996) 70:4173-4178.
    • (1996) J. Virol. , vol.70 , pp. 4173-4178
    • Gorziglia, M.1    Kadan, M.J.2    Yei, S.3
  • 37
    • 13144283616 scopus 로고    scopus 로고
    • An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
    • MORSY MA, GU M, MOTZEL S et al.: An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc. Natl. Acad. Sci. USA (1998) 95:7866-7871.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7866-7871
    • Morsy, M.A.1    Gu, M.2    Motzel, S.3
  • 38
    • 0033972740 scopus 로고    scopus 로고
    • Lentiviral vectors: Turning a deadly foe into a therapeutic agent
    • TRONO D: Lentiviral vectors: turning a deadly foe into a therapeutic agent. Gene Ther. (2000) 7:20-23.
    • (2000) Gene Ther , vol.7 , pp. 20-23
    • Trono, D.1
  • 39
    • 0032945086 scopus 로고    scopus 로고
    • Generation of retroviral vector for clinical studies using transient transfection
    • YANG S, DELGADO R, KING SR et al.: Generation of retroviral vector for clinical studies using transient transfection. Hum. Gene Ther. (1999) 10:123-132.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 123-132
    • Yang, S.1    Delgado, R.2    King, S.R.3
  • 41
    • 0035116901 scopus 로고    scopus 로고
    • The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors
    • REILLY R, MACHIELS J-P, EMENS L et al.: The collaboration of both humoral and cellular HER-2/neu-targeted immune responses is required for the complete eradication of HER-2/neu-expressing tumors. Cancer Res. (2001) 61:880-883.
    • (2001) Cancer Res. , vol.61 , pp. 880-883
    • Reilly, R.1    Machiels, J.-P.2    Emens, L.3
  • 42
    • 0030696696 scopus 로고    scopus 로고
    • Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells
    • KAWANO T, CUI J, KOEZUKA Y et al.: Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells. Science (1997) 278:1626-1629.
    • (1997) Science , vol.278 , pp. 1626-1629
    • Kawano, T.1    Cui, J.2    Koezuka, Y.3
  • 43
    • 0042808528 scopus 로고    scopus 로고
    • CD1d-restricted T cells tegulate dendritic cell function and antitumor immunity in a gran ulocyte-macrophage colony-stimulating factor-dependent fashion
    • GILLESSEN S, NAUMOV YN, NIEUWENHUIS EE et al.: CD1d-restricted T cells tegulate dendritic cell function and antitumor immunity in a gran ulocyte-macrophage colony-stimulating factor-dependent fashion. Proc. Natl. Acad. Sci. USA (2003) 100:8874-8879.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8874-8879
    • Gillessen, S.1    Naumov, Y.N.2    Nieuwenhuis, E.E.3
  • 44
    • 0032541472 scopus 로고    scopus 로고
    • Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor
    • DONG Z, YONEDA J, KUMAR R, FIDLER IJ: Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor. J. Exp. Med. (1998) 188:755-763.
    • (1998) J. Exp. Med. , vol.188 , pp. 755-763
    • Dong, Z.1    Yoneda, J.2    Kumar, R.3    Fidler, I.J.4
  • 45
    • 0032573225 scopus 로고    scopus 로고
    • Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma
    • SOIFFER R, LYNCH T, MIHM M et al.: Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl. Acad. Sci. USA (1998) 95:13141-13146.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13141-13146
    • Soiffer, R.1    Lynch, T.2    Mihm, M.3
  • 46
    • 0141576738 scopus 로고    scopus 로고
    • Vaccination with irradiated, autologus melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma
    • SOIFFER R, HODI SF, HALUSKA F et al.: Vaccination with irradiated, autologus melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor by adenoviral-mediated gene transfer augments antitumor immunity in patients with metastatic melanoma. J. Clin. Oncol. (2003) 21:3343-3350.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3343-3350
    • Soiffer, R.1    Hodi, S.F.2    Haluska, F.3
  • 47
    • 10744229445 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer
    • NEMUNAITIS J, STERMAN D, JABLONS D et al.: Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer. J. Natl. Cancer Inst. (2004) 96:326-331.
    • (2004) J. Natl. Cancer Inst. , vol.96 , pp. 326-331
    • Nemunaitis, J.1    Sterman, D.2    Jablons, D.3
  • 48
    • 0037441842 scopus 로고    scopus 로고
    • Vaccination with irradiated autologus tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    • SALGIA R, LYNCH T, SKARIN A et al.: Vaccination with irradiated autologus tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J. Clin. Oncol. (2003) 21:624-630.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 624-630
    • Salgia, R.1    Lynch, T.2    Skarin, A.3
  • 49
    • 0035152718 scopus 로고    scopus 로고
    • Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: A Phase I trial of safety and immune activation
    • JAFFEE EM, HRUBAN RH, BIEDRZYCKI B et al.: Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a Phase I trial of safety and immune activation. J. Clin. Oncol. (2001) 19:145-156.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 145-156
    • Jaffee, E.M.1    Hruban, R.H.2    Biedrzycki, B.3
  • 50
    • 0033765794 scopus 로고    scopus 로고
    • Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
    • NELSON WG, SIMONS JW, MIKHAK B et al.: Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies. Cancer Chemother. Pharmacol. (2000) 46:S67-S72.
    • (2000) Cancer Chemother. Pharmacol. , vol.46
    • Nelson, W.G.1    Simons, J.W.2    Mikhak, B.3
  • 51
    • 0030944023 scopus 로고    scopus 로고
    • Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer
    • SIMONS JW, JAFFEE EM, WEBER CE et al.: Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Res. (1997) 57:1537-1546.
    • (1997) Cancer Res. , vol.57 , pp. 1537-1546
    • Simons, J.W.1    Jaffee, E.M.2    Weber, C.E.3
  • 52
    • 0032741439 scopus 로고    scopus 로고
    • Induction of immunity to prostate cancer antigens: Results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
    • SIMONS JW, MIKHAK B, CHANG JF et al.: Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer. Cancer Res. (1999) 59:5160-5168.
    • (1999) Cancer Res. , vol.59 , pp. 5160-5168
    • Simons, J.W.1    Mikhak, B.2    Chang, J.F.3
  • 53
    • 0024215015 scopus 로고
    • Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumors in nu/nu mice
    • BUBENIK J, VOITENOK NN, KIELER J et al.: Local administration of cells containing an inserted IL-2 gene and producing IL-2 inhibits growth of human tumors in nu/nu mice. Immunol. Lett. (1988) 19:279-282.
    • (1988) Immunol. Lett. , vol.19 , pp. 279-282
    • Bubenik, J.1    Voitenok, N.N.2    Kieler, J.3
  • 54
    • 0027358652 scopus 로고
    • Gene therapy of cancer: Use of IL-2 gene transfer and kinetics of local T and NK cell subsets
    • BUBENIK J, ZEUTHEN J, BUBENIKOVA D, SIMOVA J, JANDLOVA T: Gene therapy of cancer: use of IL-2 gene transfer and kinetics of local T and NK cell subsets. Anticancer Res. (1993) 13:1457-1460.
    • (1993) Anticancer Res. , vol.13 , pp. 1457-1460
    • Bubenik, J.1    Zeuthen, J.2    Bubenikova, D.3    Simova, J.4    Jandlova, T.5
  • 55
    • 0026026646 scopus 로고
    • Decreased tumorigenicity of a transplantable rat sarcoma following transfer and expression of an IL-2 cDNA
    • RUSSELL SJ, ECCLES SA, FLEMMING CL, JOHNSON CA, COLLINS MK: Decreased tumorigenicity of a transplantable rat sarcoma following transfer and expression of an IL-2 cDNA. Int. J. Cancer (1991) 47:244-251.
    • (1991) Int. J. Cancer , vol.47 , pp. 244-251
    • Russell, S.J.1    Eccles, S.A.2    Flemming, C.L.3    Johnson, C.A.4    Collins, M.K.5
  • 56
    • 0031434792 scopus 로고    scopus 로고
    • Transfection of IL-2 augments CTL response to human melanoma cells in vitro: Immunological characterization of a melanoma vaccine
    • VAN ELSAS A, AARNOUDSE C, MINNE CE et al.: Transfection of IL-2 augments CTL response to human melanoma cells in vitro: immunological characterization of a melanoma vaccine. J. Immunother. (1997) 20:343-353.
    • (1997) J. Immunother. , vol.20 , pp. 343-353
    • Van Elsas, A.1    Aarnoudse, C.2    Minne, C.E.3
  • 57
    • 0028878570 scopus 로고
    • Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene
    • IWANUMA Y, KATO K, YAGITA H, OKUMURA K: Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene. Cancer Immunol. Immunother. (1995) 40:17-23.
    • (1995) Cancer Immunol. Immunother. , vol.40 , pp. 17-23
    • Iwanuma, Y.1    Kato, K.2    Yagita, H.3    Okumura, K.4
  • 58
    • 0025000864 scopus 로고
    • Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity
    • GANSBACHER B, ZIER K, DANIELS B, CRONIN K, BANNERJI R, GILBOA E: Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J. Exp. Med. (1990) 172:1217-1224.
    • (1990) J. Exp. Med. , vol.172 , pp. 1217-1224
    • Gansbacher, B.1    Zier, K.2    Daniels, B.3    Cronin, K.4    Bannerji, R.5    Gilboa, E.6
  • 59
    • 0025095664 scopus 로고
    • Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
    • FEARON ER, PARDOLL DM, ITAYA T et al.: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell (1990) 60:397-403.
    • (1990) Cell , vol.60 , pp. 397-403
    • Fearon, E.R.1    Pardoll, D.M.2    Itaya, T.3
  • 60
    • 0035007103 scopus 로고    scopus 로고
    • Adenovector engineered interleukin-2 expressin autologus plasma cell vaccination after high-dose chemotherapy for multiple myeloma - A Phase I study
    • TRUDEL S, LI Z, DODGSON C et al.: Adenovector engineered interleukin-2 expressin autologus plasma cell vaccination after high-dose chemotherapy for multiple myeloma - a Phase I study. Leukemia (2001) 15:846-854.
    • (2001) Leukemia , vol.15 , pp. 846-854
    • Trudel, S.1    Li, Z.2    Dodgson, C.3
  • 61
    • 0033659895 scopus 로고    scopus 로고
    • Humoral response to vaccination with interleukin-2-expressing allogeneic neuroblastoma cells after primary therapy
    • HAIGHT AE, BOWMAN LC, NG CY, VANIN EF, DAVIDOFF AM: Humoral response to vaccination with interleukin-2-expressing allogeneic neuroblastoma cells after primary therapy. Med. Pediatr. Oncol. (2000) 35:712-715.
    • (2000) Med. Pediatr. Oncol. , vol.35 , pp. 712-715
    • Haight, A.E.1    Bowman, L.C.2    Ng, C.Y.3    Vanin, E.F.4    Davidoff, A.M.5
  • 62
    • 0028905079 scopus 로고
    • Interleukin-2 gene therapy in a patient with glioblastoma
    • SOBOL RE, FAKHRAI H, SHAWLER D et al.: Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther. (1995) 2:164-167.
    • (1995) Gene Ther. , vol.2 , pp. 164-167
    • Sobol, R.E.1    Fakhrai, H.2    Shawler, D.3
  • 63
    • 0033587173 scopus 로고    scopus 로고
    • Gene therapy with autologus, interleukin-2-secreting tumor cells in patients with malignant melanoma
    • PALMER K, MOORE J, EVERARD M et al.: Gene therapy with autologus, interleukin-2-secreting tumor cells in patients with malignant melanoma. Hum. Gene Ther. (1999) 10:1261-1268.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 1261-1268
    • Palmer, K.1    Moore, J.2    Everard, M.3
  • 64
    • 2442744586 scopus 로고    scopus 로고
    • Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: Outcome of a Phase I study
    • SCHREIBER S, KAMPGEN E, WAGNER E et al.: Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a Phase I study. Hum. Gene Ther. (1999) 10:983-993.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 983-993
    • Schreiber, S.1    Kampgen, E.2    Wagner, E.3
  • 65
    • 0034689496 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with an allogeneic, genetically modified interleukin 2-producing melanoma cell line
    • OSANTO S, SCHIPHORST PP, WEIJL NI et al.: Vaccination of melanoma patients with an allogeneic, genetically modified interleukin 2-producing melanoma cell line. Hum. Gene Ther. (2000) 11:739-750.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 739-750
    • Osanto, S.1    Schiphorst, P.P.2    Weijl, N.I.3
  • 66
    • 0029090362 scopus 로고
    • Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma
    • LAW TM, MOTZER RJ, MAZUMDAR M et al.: Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma. Cancer (1995) 76:824-832.
    • (1995) Cancer , vol.76 , pp. 824-832
    • Law, T.M.1    Motzer, R.J.2    Mazumdar, M.3
  • 67
    • 0028082117 scopus 로고
    • A Phase II clinical trial of interleukin-2 and lymphokine-activated killer cells in advanced colorectal carcinoma
    • HAWKINS MJ, ATKINS MB, DUTCHER JP et al.: A Phase II clinical trial of interleukin-2 and lymphokine-activated killer cells in advanced colorectal carcinoma. J. Immunother. (1994) 15:74-78.
    • (1994) J. Immunother. , vol.15 , pp. 74-78
    • Hawkins, M.J.1    Atkins, M.B.2    Dutcher, J.P.3
  • 68
    • 0032698796 scopus 로고    scopus 로고
    • Phase I clinical study applying autologus immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma
    • SCHMIDT-WOLF IG, FINKE S, TROJANECK B et al.: Phase I clinical study applying autologus immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br. J. Cancer (1999) 81:1009-1016.
    • (1999) Br. J. Cancer , vol.81 , pp. 1009-1016
    • Schmidt-Wolf, I.G.1    Finke, S.2    Trojaneck, B.3
  • 69
    • 0032826943 scopus 로고    scopus 로고
    • Gene therapy with cytokine-transfected xenogeneic cells (Vero-IL-2) in patients with metastatic solid tumors: Mechanism(s) of elimination of the transgene-carrying cells
    • JANTSCHEFF P, HERRMANN R, SPAGNOLI G et al.: Gene therapy with cytokine-transfected xenogeneic cells (Vero-IL-2) in patients with metastatic solid tumors: mechanism(s) of elimination of the transgene-carrying cells. Cancer Immunol. Immunother. (1999) 48:321-330.
    • (1999) Cancer Immunol. Immunother. , vol.48 , pp. 321-330
    • Jantscheff, P.1    Herrmann, R.2    Spagnoli, G.3
  • 70
    • 0033665927 scopus 로고    scopus 로고
    • Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: Clinical and immunological findings
    • TARTOUR E, MEHTALI M, SASTRE-GARAU X et al.: Phase I clinical trial with IL-2-transfected xenogeneic cells administered in subcutaneous metastatic tumours: clinical and immunological findings. Br. J. Cancer (2000) 83:1454-1461.
    • (2000) Br. J. Cancer , vol.83 , pp. 1454-1461
    • Tartour, E.1    Mehtali, M.2    Sastre-Garau, X.3
  • 71
    • 0025604195 scopus 로고
    • Retroviral vector mediated gamma Interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity
    • GANSBACHER B, BANNERJI R, DANIELS B, ZIER K, CRONIN K, GILBOA E: Retroviral vector mediated gamma Interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res. (1990) 50:7820-7825.
    • (1990) Cancer Res. , vol.50 , pp. 7820-7825
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3    Zier, K.4    Cronin, K.5    Gilboa, E.6
  • 73
    • 0011951868 scopus 로고
    • Introduction to the interferon system
    • Baron S, Coppenhaver DH, Dianzani F (Eds), Galveston, University of Texas, TX, USA
    • BARON S, COPPENHAVER DH, DIANZANI F et al.: Introduction to the interferon system. In: Interferon: Principles and Medical Applications. Baron S, Coppenhaver DH, Dianzani F (Eds), Galveston, University of Texas, TX, USA (1992):1-15.
    • (1992) Interferon: Principles and Medical Applications , pp. 1-15
    • Baron, S.1    Coppenhaver, D.H.2    Dianzani, F.3
  • 74
    • 0027202016 scopus 로고
    • Enhanced expression of HLA molecules and stimulation of autologous human tumor infiltrating lymphocytes following transducrion of melanoma cells with gamma IFN genes
    • OGASARAWA M, ROSENBERG S: Enhanced expression of HLA molecules and stimulation of autologous human tumor infiltrating lymphocytes following transducrion of melanoma cells with gamma IFN genes. Cancer Res. (1993) 53:3561-3568.
    • (1993) Cancer Res. , vol.53 , pp. 3561-3568
    • Ogasarawa, M.1    Rosenberg, S.2
  • 75
    • 0028511099 scopus 로고
    • Transducrion of human melanoma cells with the gamma interferon gene enhances cellular immunity
    • ABDEL-WAHAB Z, OSANTO S, DARROW TL et al.: Transducrion of human melanoma cells with the gamma interferon gene enhances cellular immunity. Cancer Gene Ther. (1994) 1:171-179.
    • (1994) Cancer Gene Ther. , vol.1 , pp. 171-179
    • Abdel-Wahab, Z.1    Osanto, S.2    Darrow, T.L.3
  • 76
    • 0033662405 scopus 로고    scopus 로고
    • CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNγ receptor expression by nonhematopoietic cells
    • QIN Z, BLANKENSTEIN T: CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFNγ receptor expression by nonhematopoietic cells. Immunity (2000) 12:677-686.
    • (2000) Immunity , vol.12 , pp. 677-686
    • Qin, Z.1    Blankenstein, T.2
  • 77
    • 0026661047 scopus 로고
    • Distribution of interferon-gamma receptor in human tissues
    • VALENTE G, OZMEN L, NOVELLI F et al.: Distribution of interferon-gamma receptor in human tissues. Eur. J. Immunol. (1992) 22:2403-2412.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2403-2412
    • Valente, G.1    Ozmen, L.2    Novelli, F.3
  • 78
    • 12644261448 scopus 로고    scopus 로고
    • Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
    • SGADARI C, ANGIOLILLO AL, CHERNEY BW et al.: Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc. Natl. Acad. Sci. USA (1996) 93:13791-13796.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13791-13796
    • Sgadari, C.1    Angiolillo, A.L.2    Cherney, B.W.3
  • 79
    • 0031001933 scopus 로고    scopus 로고
    • Mig, the monokine induced by interferon-gamma promotes rumor necrosis in vivo
    • SGADARI C, FARBER JM, ANGIOLILLO AL et al.: Mig, the monokine induced by interferon-gamma promotes rumor necrosis in vivo. Blood (1997) 89:2635-2643.
    • (1997) Blood , vol.89 , pp. 2635-2643
    • Sgadari, C.1    Farber, J.M.2    Angiolillo, A.L.3
  • 81
    • 0030820018 scopus 로고    scopus 로고
    • A Phase I clinical trial of immunotherapy with interferon-γ gene-modified autologous melanoma cells
    • ABDEL-WAHAB Z, WELTZ C, HESTER D et al.: A Phase I clinical trial of immunotherapy with interferon-γ gene-modified autologous melanoma cells. Cancer (1997) 80:401-412.
    • (1997) Cancer , vol.80 , pp. 401-412
    • Abdel-Wahab, Z.1    Weltz, C.2    Hester, D.3
  • 82
    • 0026331269 scopus 로고
    • Treatment of established renal cancer by tumor cells engineered to secrete inteleukin-4
    • GOLUMBEK PT, LAZENBY AJ, LEVITSKY HI et al.: Treatment of established renal cancer by tumor cells engineered to secrete inteleukin-4. Science (1991) 254:713-716.
    • (1991) Science , vol.254 , pp. 713-716
    • Golumbek, P.T.1    Lazenby, A.J.2    Levitsky, H.I.3
  • 83
    • 0026657391 scopus 로고
    • An eosinophil-dependent mechanism for the anti-tumor effect of interleukin-4
    • TEPPER RI, COFFMAN RL, LEDER P: An eosinophil-dependent mechanism for the anti-tumor effect of interleukin-4. Science (1992) 257:548-551.
    • (1992) Science , vol.257 , pp. 548-551
    • Tepper, R.I.1    Coffman, R.L.2    Leder, P.3
  • 84
    • 0027407938 scopus 로고
    • Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin-2, inteleukin-4, interleukin-7, tumor necrosis factor, or interferon gamma
    • HOCK H, DORSCH M, KUNZENDORF U, QIN Z, DIAMANTSTEIN T, BLANKENSTEIN T: Mechanisms of rejection induced by tumor cell-targeted gene transfer of interleukin-2, inteleukin-4, interleukin-7, tumor necrosis factor, or interferon gamma. Proc. Natl. Acad. Sci. USA (1993) 90:2774-2778.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2774-2778
    • Hock, H.1    Dorsch, M.2    Kunzendorf, U.3    Qin, Z.4    Diamantstein, T.5    Blankenstein, T.6
  • 85
    • 0028062979 scopus 로고
    • An efficient Th2-type memory follows CDS+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4
    • PERICLE F, GIOVARELLI M, COLOMBO MP et al.: An efficient Th2-type memory follows CDS+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4. J. Immunol. (1994) 153:5659-5673.
    • (1994) J. Immunol. , vol.153 , pp. 5659-5673
    • Pericle, F.1    Giovarelli, M.2    Colombo, M.P.3
  • 86
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor α
    • SALLUSTO F, LANZAVECCHIA A: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor α. J. Exp. Med. (1994) 179:1109-1118.
    • (1994) J. Exp. Med. , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 87
    • 0033544933 scopus 로고    scopus 로고
    • Vaccination of melanoma patients with interleukin 4 gene-transduced allogeneic melanoma cells
    • ARIENTI F, BELLI F, NAPOLITANO F et al.: Vaccination of melanoma patients with interleukin 4 gene-transduced allogeneic melanoma cells. Hum. Gene Ther. (1999) 10:2907-2916.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 2907-2916
    • Arienti, F.1    Belli, F.2    Napolitano, F.3
  • 88
    • 0031756584 scopus 로고    scopus 로고
    • Active immunization of metastatic melanoma patients with IL-2 or IL-4 gene transfected, allogeneic melanoma cells
    • BELLI F, MASCHERONI L, GALLINO G et al.: Active immunization of metastatic melanoma patients with IL-2 or IL-4 gene transfected, allogeneic melanoma cells. Adv. Exp. Med. Biol. (1998) 451:543-545.
    • (1998) Adv. Exp. Med. Biol. , vol.451 , pp. 543-545
    • Belli, F.1    Mascheroni, L.2    Gallino, G.3
  • 89
    • 0036181209 scopus 로고    scopus 로고
    • Vaccination of stage IV patients with allogeneis IL-4 or IL-2-gene transduced melanoma cells generates functional antibodies against vaccinating and autologous melanoma cells
    • MAIO M, FONSATTI E, LAMAJ E et al.: Vaccination of stage IV patients with allogeneis IL-4 or IL-2-gene transduced melanoma cells generates functional antibodies against vaccinating and autologous melanoma cells. Cancer Immunol. Immunother. (2002) 51:9-14.
    • (2002) Cancer Immunol. Immunother. , vol.51 , pp. 9-14
    • Maio, M.1    Fonsatti, E.2    Lamaj, E.3
  • 90
    • 0027136087 scopus 로고
    • Transduction of human melanoma cell lines with human interleukin-7 gene using retroviral-mediated gene transfer: Comparison of immunologic properties with interleukin-2
    • MILLER A, MCBRIDE W, DUBINETT S et al.: Transduction of human melanoma cell lines with human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2. Blood (1993) 18:3686-3694.
    • (1993) Blood , vol.18 , pp. 3686-3694
    • Miller, A.1    Mcbride, W.2    Dubinett, S.3
  • 91
    • 0027437465 scopus 로고
    • Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts
    • MURPHY W, BACK T, CONLON K et al.: Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts. J. Clin. Invest. (1993) 92:1918-1924.
    • (1993) J. Clin. Invest. , vol.92 , pp. 1918-1924
    • Murphy, W.1    Back, T.2    Conlon, K.3
  • 92
    • 0031178573 scopus 로고    scopus 로고
    • Increase of cytotoxic sensitivity of primary human melanoma cells transfected with the interlukin-7 gene to autologous and allogeneic immunologic effector cells
    • FINKE S, TROJANECK B, MOLLER P et al.: Increase of cytotoxic sensitivity of primary human melanoma cells transfected with the interlukin-7 gene to autologous and allogeneic immunologic effector cells. Cancer Gene Ther. (1997) 4:260-268.
    • (1997) Cancer Gene Ther. , vol.4 , pp. 260-268
    • Finke, S.1    Trojaneck, B.2    Moller, P.3
  • 93
    • 85047698246 scopus 로고    scopus 로고
    • Comparative assessment of TCRBV diversity in T lymphocytes present in blood, metastatic lesions, and DTH sites of two melanoma patients vaccinated with an IL-7 gene-modified autologous tumor cell vaccine
    • CARSANA M, TRAGNI G, NICOLINI G et al.: Comparative assessment of TCRBV diversity in T lymphocytes present in blood, metastatic lesions, and DTH sites of two melanoma patients vaccinated with an IL-7 gene-modified autologous tumor cell vaccine. Cancer Gene Ther. (2002) 9:243-253.
    • (2002) Cancer Gene Ther. , vol.9 , pp. 243-253
    • Carsana, M.1    Tragni, G.2    Nicolini, G.3
  • 94
    • 0035835377 scopus 로고    scopus 로고
    • Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: A first clinical Phase I/II trial
    • WITTIG B, MARTEN A, DORBIC T et al.: Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: a first clinical Phase I/II trial. Hum. Gene Ther. (2001) 12:267-278.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 267-278
    • Wittig, B.1    Marten, A.2    Dorbic, T.3
  • 95
    • 0030879639 scopus 로고    scopus 로고
    • Cytokine gene therapy of cancer using gene gun technology: Superior antitumor activity of IL-12
    • RAKHMILEVICH AL, JANSSEN K, TURNER J, CULP J, YANG NS: Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of IL-12 Hum. Gene Ther. (1997) 8:1303-1311.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1303-1311
    • Rakhmilevich, A.L.1    Janssen, K.2    Turner, J.3    Culp, J.4    Yang, N.S.5
  • 96
    • 0029148905 scopus 로고
    • Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts
    • ZITVOGEL L, TAHARA H, ROBBINS PD et al.: Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J. Immunol. (1995) 155:1393-1403.
    • (1995) J. Immunol. , vol.155 , pp. 1393-1403
    • Zitvogel, L.1    Tahara, H.2    Robbins, P.D.3
  • 97
    • 0033017095 scopus 로고    scopus 로고
    • Gene gun-mediated IL-12 gene therapy induces antitumour effects in the absence of toxicity: A direct comparison with systemic IL-12 protein therapy
    • RAKHMILEVICH AL, TIMMINS JG, JANSSEN K, POHLMANN EL, SHEEHY MJ, YANG NS: Gene gun-mediated IL-12 gene therapy induces antitumour effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy. J. Immunother. (1999) 22:135-144.
    • (1999) J. Immunother. , vol.22 , pp. 135-144
    • Rakhmilevich, A.L.1    Timmins, J.G.2    Janssen, K.3    Pohlmann, E.L.4    Sheehy, M.J.5    Yang, N.S.6
  • 98
    • 12144288325 scopus 로고    scopus 로고
    • Complete tumour regression induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice
    • LASEK W, BASAK G, SWITAJ T et al.: Complete tumour regression induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice. Cancer Immunol. Immunother. (2004) 53:363-372.
    • (2004) Cancer Immunol. Immunother. , vol.53 , pp. 363-372
    • Lasek, W.1    Basak, G.2    Switaj, T.3
  • 99
    • 3042628507 scopus 로고    scopus 로고
    • CpG immunostimulatory oligodeoxynucleotide 1826 enhances antitumor effect of interleukin 12 gene-modified tumor vaccine in a melanoma model in mice
    • SWITAJ T, JALILI A, JAKUBOWSKA AB et al.: CpG immunostimulatory oligodeoxynucleotide 1826 enhances antitumor effect of interleukin 12 gene-modified tumor vaccine in a melanoma model in mice. Clin. Cancer Res. (2004) 10:4165-4175.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4165-4175
    • Switaj, T.1    Jalili, A.2    Jakubowska, A.B.3
  • 100
    • 0026532085 scopus 로고
    • A comparative study of IL-12 (cytotoxic lymphocyte maturation factor) IL-2, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells
    • NAUME B, GATELY M, ESPEVIK T: A comparative study of IL-12 (cytotoxic lymphocyte maturation factor) IL-2, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells. J. Immunol. (1992) 148:2429-2436.
    • (1992) J. Immunol. , vol.148 , pp. 2429-2436
    • Naume, B.1    Gately, M.2    Espevik, T.3
  • 101
    • 0031895957 scopus 로고    scopus 로고
    • Vaccination with IL-12 gene-modified autologous melanoma cells: Preclinical results and a first clinical Phase I study
    • SUN Y, JURGOVSKY K, MOLLER P et al.: Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical Phase I study. Gene Ther. (1998) 5:481-490.
    • (1998) Gene Ther. , vol.5 , pp. 481-490
    • Sun, Y.1    Jurgovsky, K.2    Moller, P.3
  • 102
    • 0035831628 scopus 로고    scopus 로고
    • Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a Phase I study
    • KANG WK, PARK C, YOON HL et al.: Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a Phase I study. Hum. Gene Ther. (2001) 12:671-684.
    • (2001) Hum. Gene Ther. , vol.12 , pp. 671-684
    • Kang, W.K.1    Park, C.2    Yoon, H.L.3
  • 103
    • 0032152332 scopus 로고    scopus 로고
    • Phase I trial of retro viral vector-mediated Interferon (IFN)-gamma gene transfer into autologous tumor cells in patients with metastatic melanoma
    • NEMUNAITIS J, BOHART C, FONG T et al.: Phase I trial of retro viral vector-mediated Interferon (IFN)-gamma gene transfer into autologous tumor cells in patients with metastatic melanoma. Cancer Gene Ther. (1998) 5:292-300.
    • (1998) Cancer Gene Ther. , vol.5 , pp. 292-300
    • Nemunaitis, J.1    Bohart, C.2    Fong, T.3
  • 104
    • 0028719087 scopus 로고
    • Immunotherapy of cancer using cytokine gene-modified tumor vaccines
    • GILBOA E, LYERLY HK, VIEWEG J, SAITO S: Immunotherapy of cancer using cytokine gene-modified tumor vaccines. Semin. Cancer Biol. (1994) 5:409-417.
    • (1994) Semin. Cancer Biol. , vol.5 , pp. 409-417
    • Gilboa, E.1    Lyerly, H.K.2    Vieweg, J.3    Saito, S.4
  • 105
    • 0029085126 scopus 로고
    • Interleukin-6-type cytokines and their receptors for gene therapy of melanoma
    • discussion 373-374
    • MACKIEWICZ A, WIZNEROWICZ M, ROEB E et al.: Interleukin-6-type cytokines and their receptors for gene therapy of melanoma. Ann. NY Acad. Sci. (1995) 762:361-373; discussion 373-374.
    • (1995) Ann. NY Acad. Sci. , vol.762 , pp. 361-373
    • Mackiewicz, A.1    Wiznerowicz, M.2    Roeb, E.3
  • 106
    • 0028965563 scopus 로고
    • Soluble interleukin 6 receptor is biologically active in vivo
    • MACKIEWICZ A, WlZNEROWlCZ M, ROEB E et al.: Soluble interleukin 6 receptor is biologically active in vivo. Cytokine (1995) 7:142-149.
    • (1995) Cytokine , vol.7 , pp. 142-149
    • Mackiewicz, A.1    Wlznerowlcz, M.2    Roeb, E.3
  • 107
    • 0030614539 scopus 로고    scopus 로고
    • A bioactive designer cytokine for human hematopoietic progenitor cell expansion
    • FISCHER M, GOLDSCHMITT J, PESCHEL C et al.: A bioactive designer cytokine for human hematopoietic progenitor cell expansion. Nat. Biotechnol. (1997) 15:142-145.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 142-145
    • Fischer, M.1    Goldschmitt, J.2    Peschel, C.3
  • 108
    • 0035931857 scopus 로고    scopus 로고
    • The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells
    • OZBEK S, PETERS M, BREUHAHN K et al.: The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells. Oncogene (2001) 20:972-979.
    • (2001) Oncogene , vol.20 , pp. 972-979
    • Ozbek, S.1    Peters, M.2    Breuhahn, K.3
  • 109
    • 0028982471 scopus 로고
    • Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor
    • MACKIEWlCZ A, GORNY A, LACIAK M et al.: Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor. Hum. Gene Ther. (1995) 6:805-811.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 805-811
    • Mackiewlcz, A.1    Gorny, A.2    Laciak, M.3
  • 110
    • 0030782130 scopus 로고    scopus 로고
    • Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: Application to melanoma vaccine development
    • WIZNEROWICZ M, FONG AZ, MACKIEWlCZ A, HAWLEY RG: Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: application to melanoma vaccine development. Gene Ther. (1997) 4:1061-1068.
    • (1997) Gene Ther. , vol.4 , pp. 1061-1068
    • Wiznerowicz, M.1    Fong, A.Z.2    Mackiewlcz, A.3    Hawley, R.G.4
  • 111
    • 0035697637 scopus 로고    scopus 로고
    • Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor
    • NAWROCKI S, LACIAK M, IZYCKI D et al.: Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor. Adv. Exp. Med. Biol. (2001) 495:411-418.
    • (2001) Adv. Exp. Med. Biol. , vol.495 , pp. 411-418
    • Nawrocki, S.1    Laciak, M.2    Izycki, D.3
  • 112
    • 0033514923 scopus 로고    scopus 로고
    • Immune surveillance against a solid tumor fails because of immunological ignorance
    • OCHSENBEIN AF, KLENERMAN P, KARRER U et al.: Immune surveillance against a solid tumor fails because of immunological ignorance. Proc. Natl. Acad. Sci. USA (1999) 96:2233-2238.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2233-2238
    • Ochsenbein, A.F.1    Klenerman, P.2    Karrer, U.3
  • 114
    • 0032152332 scopus 로고    scopus 로고
    • Phase I trial of retroviral vector-mediated Interferon (IFN)-gamma gene transfer into autologous tumor cells in patients with metastatic melanoma
    • NEMUNAITIS J, BOHART C, FONG T et al.: Phase I trial of retroviral vector-mediated Interferon (IFN)-gamma gene transfer into autologous tumor cells in patients with metastatic melanoma. Cancer Gene Ther. (1998) 5:292-300.
    • (1998) Cancer Gene Ther. , vol.5 , pp. 292-300
    • Nemunaitis, J.1    Bohart, C.2    Fong, T.3


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