Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-1 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma

British Journal of Cancer

Volumn 81, Issue 6, 1999, Pages 1009-1016

  Schmidt Wolf, I G H ^a   Finke, S ^a   Trojaneck, B ^a   Denkena, A ^a   Lefterova, P ^a   Schwella, N ^a   Heuft, H G ^a   Prange, G ^a   Korte, M ^a   Takeya, M ^c   Dorbic, T ^c   Neubauer, A ^b   Wittig, B ^c   Huhn, D ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Colorectal cancer; Cytokine induced killer cells; Gene transfer; Interleukin 2; Lymphoma; Renal cancer

Indexed keywords

CD3 ANTIGEN; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; AUTOTRANSPLANTATION; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; ELECTROPORATION; FEMALE; FEVER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CANCER; KIDNEY CARCINOMA; LEUKAPHERESIS; LYMPHOCYTE COUNT; LYMPHOMA; MALE; PHASE 1 CLINICAL TRIAL; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; CARCINOMA, RENAL CELL; COLORECTAL NEOPLASMS; FEMALE; GENE THERAPY; HUMANS; IMMUNOTHERAPY; INTERLEUKIN-2; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; LYMPHOMA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 0032698796     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690800     Document Type: Article

References (26)

1. Buschle M, Cotten M, Kirlappos H, Mechtler K, Schaffner G, Zauner W, Birustiel ML and Wagner E (1995) Receptor-mediated gene transfer into human T lymphocytes via binding of DNA/CD3 antibody particles to the CD3 T cell receptor complex. Human Gene Ther 6: 753-761
2. Csipai M, Lefterova P, Niemitz S, Johnston V, Scheffold C, Huhn D and Schmidt-Wolf IGH (1996) Effects of interleukin-7 on proliferation of tumour cells. Cancer Res Ther Control 5: 11-16
3. Ebert O, Finks S, Sulahi A, Herrmann M, Trojaneck B, Lefterova P, Wagner E, Kircheis R. Neubauer A, Huhn D, Schriever F, Wittig B and Schmidt-Wolf IGH (1997) Lymphocyte apoptosis: induction by gene transfer techniques. Gene Ther 4: 296-302
4. Finke S, Trojaneck B, Lefterova P, Csipai M, Wagner E, Kircheis R, Neubauer A, Huhn D, Wittig B and Schmidt-Wolf IGH (1998) Increase of proliferation rate and enhancement of antitumour cytotoxicity of expanded human CD3+CD564 immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene. Gene Ther 5: 31-39
5. Grimm EA, Mazumder A, Zhang HZ and Rosenberg SA (1982) Lymphokine acitivated killer cell phenomenon: lysis of natural killer resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes. J Exp Med 155: 1823-1841
6. Hickman CJ, Crim JA, Mostowski HS and Siegel JP (1990) Regulation of human cytotoxic T-lymphocyte development by IL-7. J Immunol 145: 2415-2420
7. Hwu P, Yanelli J, Kriegler M, Anderson WF, Perez C, Chiang Y, Schwarz S, Cowherd R, Delgado C, Mule J and Rosenberg SA (1993) Functional and molecular characterization of tumour-infiltrating lymphocytes transduced with tumour necrosis, factor alpha cDNA for the gene therapy of cancer in humans. J Immunol 150: 4104-4115
8. Lotze MT, Grimm EA, Mazumder A, Strausser JL and Rosenberg SA (1981) Lysis of fresh and cultured autologous tumour by human lymphocytes cultured in T cell growth factor. Cancer Res 41: 4420-4425
9. Lu PH and Negrin RS (1994) A novel population of expanded human CD3+ CD56+ cells derived from T cells with potent in vivo antitumour activity in SCID mice. J Immunol 153: 1687-1696
10. Lynch DH and Miller RE (1990) Induction of murine lymphokine-activated killer cells by recombinant IL-7. J Immunol 145: 1983-1990
11. Margolin KA, Negrin RS, Wong KK, Chatterjee S, Wright C, Forman SJ (1997) Cellular immunotherapy and autologous transplantation for hematologic malignancy. Immunol Rev 157: 231-240
12. Markowitz SD and Roberts AB (1996) Tumour suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev 7: 93-102
13. Mehta BA, Schmidt-Wolf IGH, Weissman IL and Negrin RS (1995) Two pathways of exocytosis of cytoplasmic granule contents and target cell killing by cytokine induced CD3 + CD56 + killer cells. Blood 86: 3493-3499
14. Ramp U, Jaquet K, Reinecke P, Nitsch T, Gabbert HE and Gerharz CD (1997) Aquisition of TGF-beta 1 resistance: an important progression factor in human renal cell carcinoma. Lab Invest 76: 739-749
15. Riedl E, Strobl H, Majdie O and Knapp W (1997) TGF-Beta 1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis. J Immunol 158: 1591-1597
16. Rosenberg SA, Spiess P and Lafreniere R (1986) A new approach to the adoptive immunotherapy of cancer with tumor infiltrating lymphocytes. Science 233: 1318-1321
17. Rosenberg SA, Aebersold P and Cornetta K (1990) Gene transfer into humans: immunotherapy of patients with advanced melanoma, using tumor infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323: 570-578
18. Schmidt-Wolf GD and Schmidt-Wolf IGH (1996) Cancer and gene therapy. Ann Hematol 73: 207-218
19. Schmidt-Wolf IGH, Negrin RS, Kiem HP, Blume KG and Weissmann IL (1991) Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 174: 139-149
20. Schmidt-Wolf IGH, Lefterova P, Johnston V, Huhn D, Blume KG and Weissmann H, (1994a) Propagation of large numbers of T cells with natural killer cell markers. Br J Haematol 87: 453-458
21. Schmidt Wolf IGH, Neubauer A, Finke S, Csipai M, Wittig B and Huhn D (1994b) Interleukin-7 gene therapy for patients with metastatic colon cancer, renal cell cancer, malignant melanoma or lymphoma. Human Gene Ther 5(9): 1161-1168
22. Schmidt-Wolf GD, Negrin RS and Schmidt-Wolf IGH (1997) Activated T cells and cytokine-induced CD3+CD56+killer cells. Ann Hematol 74: 51-56
23. Welch PA, Namen AE, Goodwin RG, Armitage R and Cooper MD (1989) Human IL-7: novel T-cell growth factor. J Immunol 143: 3562-3567
24. World Health Organization (1979) WHO Handbook for Reporting Results of Cancer Treatment, WHO: Geneva
25. Wright JA and Huang A (1996) Growth factors in mechanisms of malignancy: roles for TGF-beta and FGE Histol Histopathol 11: 521-536
26. Zoll B, Lefterova P, Finke S, Trojaneck B, Ebert O, Micka B, Roigk K, Fehlinger M, Schmidt-Wolf GD, Huhn D and Schmidt Wolf IGH (1998) Generation of cytokine-induced killer (CIK) cells using exogenous iterleukin-2 (IL-2), -7 (IL 7) or -12 (IL-12). Cancer Immunol Immunother 47: 221-226