Active immunization of metastatic melanoma patients with IL-2 or IL-4 gene transfected, allogeneic melanoma cells

Advances in Experimental Medicine and Biology

Volumn 451, Issue , 1998, Pages 543-545

  Belli, F ^a   Mascheroni, L ^a   Gallino, G ^a   Lenisa, L ^a   Arienti, F ^a   Melani, C ^a   Colombo, M P ^a   Parmiani, G ^a   Cascinelli, N ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 4;

ACTIVE IMMUNIZATION; ALLOGRAFT; ANTIGEN EXPRESSION; ARTICLE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; PRIORITY JOURNAL; RETROVIRUS; SKIN METASTASIS; TUMOR GROWTH;

EID: 0031756584     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5357-1_84     Document Type: Article

References (8)

1. Mulligan RC, 1993: The basic science of gene therapy. Science 260: 926-932.
2. Parmiani G, Colombo MP, Melani C, Arienti F, 1997: Cytokine gene transduction in the immunotherapy of cancer. Advances in Pharmacology 40: 1054-3589/97.
3. Colombo MP and Forni G, 1994. Cytokine gene transfer in tumor inhibition and tumor therapy: Where are we now? Immunol Today 15: 47-51.
4. Porgador A, Bannerji R, Watanabe Y, Feldman M, Gilboa E, Eisenbach L, 1993a: Antimetastatic vaccination of tumor-bearing mice with two types of IFN-γ gene-inserted tumor cells. J Immunol 150: 1458-1470.
5. Porgador A, Gansbacher B, Bannerji R, Tzehoval E, Gilboa E, Feldman M, Eisenbach L, 1993b: Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells. Int J Cancer 53: 471-477.
6. Arienti F, Sulé-Suso J, Melani C, Maccalli C, Belli F, Illeni MT, Anichini A, Cascinelli N, Colombo MP, Parmiani G, 1994: Interleukin-2 gene transduced human melanoma cells efficiently stimulate MHC-unrestricted and MHC-restricted autologous lymphocytes. Hum Gen Ther 5: 139.
7. Belli F, Arienti F, Sulé-Suso J, Clemente C, Mascheroni L, Cattelan A, Sanantonio C, et al. 1997: Active immunization of metastatic melanoma patients with interleukin-2-transduced allogeneic melanoma cells: evaluation of efficacy and tolerability. Cancer Immunol Immunother 44: 197-203.
8. Arienti F, Sulé-Suso J, Belli F, Mascheroni L, Rivoltini L, Melani C, Maio M, 1996: Limited anti-tumor T-cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells. Hum Gene Ther 7: 1955.