Non-phosphopeptide inhibitor for Lck SH2 domain: Solid-phase synthesis and structure activity relationship of rosmarinic acid analogs

Bulletin of the Korean Chemical Society

Volumn 24, Issue 5, 2003, Pages 664-666

  Kang, Sun Hee ^a   Park, See Hyoung ^b   Shim, Hyeung Soo ^a   Lee, Keun Hyeung ^a  

^a Inha University   (South Korea)

^b Mogam Biotechnology Research Institute   (South Korea)

Author keywords

ELISA; Inhibitor; Lck SH2; Non phosphopeptide; Rosmarinic acid

Indexed keywords

CELL PROTEIN; PHOSPHOPEPTIDE; PHOSPHOPEPTIDE INHIBITOR; PROTEIN LCK; ROSMARINIC ACID; ROSMARINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DRUG SYNTHESIS; INHIBITION KINETICS; MOLECULAR WEIGHT; PEPTIDE ANALYSIS; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SH2 DOMAIN; SOLID PHASE EXTRACTION; SRC HOMOLOGY DOMAIN; STRUCTURE ACTIVITY RELATION;

EID: 0042592995     PISSN: 02532964     EISSN: None     Source Type: Journal    
DOI: 10.5012/bkcs.2003.24.5.664     Document Type: Article

References (14)

1. Cantley, L. C.; Auger, K. R.; Carpenter, C.; Duckworth, B.; Graziani, A. ; Kappeller, R.; Soltoff, S. Cell 1991, 64, 241.
2. Botfield, M. C.; Green, J. Ann. Rep. Med. Chem. 1995, 30, 227.
3. (a) Garcia-Echeverria, C. Curr. Med. Chem. 2001, 13, 1589.
4. (b) Broadbridge, R. J.; Sharma, R. P. Current Drug Targets 2000, 1, 365.
5. (c) Beaulieu, P. L.; Cameron, D. R.; Ferland, J. M.; Gauthier, J.; Ghiro, E.; Gillard, J.; Gorys, V.; Poirier, M.; Rancourt, J.; Wernic, D.; Llinas-Brunet, M.; Betageri, R.; Cardozo, M.; Hickey, E. R.; Ingraham, R.; Jakes, S.; Kabcenell, A.; Kirrane, T.; Lukas, S.; Patel, U.; Proudfoot, J.; Sharma, R.; Tong, L.; Moss, N. J. Med. Chem. 1999, 42, 1757.
6. (d) Morelock, M. M.; Ingraham, R. H.; Betageri, R.; Jakes, S. J. Med. Chem. 1995, 38, 1309.
7. Vu, C. B. Curr. Med. Chem. 2000, 10, 1081.
8. Songyang, Z.; Shoelson, S. E.; Chaudhuri, M.; Gish, G.; Pawson, T.; Haser, W. G.; King, F.; Roberts, T.; Patnofsky, S.; Lechleider, R. J.; Neel, B. G.; Birge, B.; Cantley, L. C. Cell 1993, 72, 767.
9. Hur, E. M.; Choi, B.; Park, C.; Lee, J.; Park, D.; Yun, Y.; Lee, K. H.; Oh, J. E.; Ahn, C. S.; Lee, H. S.; Ahn, J. S.; Jung, S. I. U.S. 6,140,363 October 31, 2000.
10. Won, J.; Hur, E. M.; Hur, Y.; Park, S.; Kang, M.; Choi, Y.; Park, C.; Lee, K. H.; Yun, Y. Eur. J. Immunology 2003, 33, 870.
11. Hu, B.; Messersmith, P. B. Tetrahedron Lett. 2000, 41, 5795.
12. Kaiser, E.; Colescott, R. L.; Bossinger, C. D.; Cook, P. I. Anal. Biochem. 1970, 34, 595.
13. Gilmer, T.; Rodriguez, M.; Jordan, S.; Crosby, R.; Alligood, K.; Green, K.; Kimery, M.; Wagner, C.; Kinder, D.; Charifson, P.; Hassell, A. M.; Willard, D.; Luther, M.; Rusnak, D.; Sternbach, D. D.; Mehrotra, M.; Peel, M.; Shampine, L.; Davis, R.; Robbins, J.; Patel, I. R.; Kassel, D.; Burkhart, W.; Moyer, M.; Bradshaw, T.; Berman, J. J. Biol. Chem. 1994, 269, 31711.
14. Eck, M. J.; Atwell, S. K.; Shoelson, S. E.; Harrison, S. C. Nature 1994, 368, 764.