Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: Possible implications for GAI pathogenesis

Neurobiology of Disease

Volumn 32, Issue 3, 2008, Pages 528-534

  Olivera, Silvia ^a   Fernandez, Anabel ^b   Latini, Alexandra ^c   Rosillo, Juan Carlos ^b   Casanova, Gabriela ^d   Wajner, Moacir ^c   Cassina, Patricia ^e   Barbeito, Luis ^a  

^a INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Cellular Biology Section   (Uruguay)

^e DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

Astrocyte proliferation; Glutaric acidemia I; Mitochondria dysfunction

Indexed keywords

GLUTARIC ACID; PORPHYRIN;

ACIDEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN REGION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GLUTARIC ACIDEMIA; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RAT; STRIATE CORTEX;

AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; ANIMALS, NEWBORN; ANTHRACENES; ANTIOXIDANTS; ASTROCYTES; BRAIN; BRAIN DISEASES, METABOLIC, INBORN; BUTADIENES; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; GLUTARATES; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NITRILES; PORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 56349117561     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.09.011     Document Type: Article

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