The effect of long-term repeated exposure to 3,4- methylenedioxymethamphetamine on cardiovascular and thermoregulatory changes

Psychopharmacology

Volumn 201, Issue 2, 2008, Pages 161-170

  Jaehne, Emily Joy ^a   Salem, Abdallah ^a   Irvine, Rodney James ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Behavior; Cardiovascular; Ecstasy; MDMA; Neurotransmitter; Thermoregulation

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CARDIOVASCULAR EFFECT; DOSE RESPONSE; DRUG ABUSE; DRUG DOSE INCREASE; DRUG EFFECT; HEART RATE; HYPERTHERMIA; MALE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; THERMOREGULATION;

3,4-DIHYDROXYPHENYLACETIC ACID; 3,4-METHYLENEDIOXYAMPHETAMINE; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE REGULATION; CEREBRAL CORTEX; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; HEART RATE; HOT TEMPERATURE; HUMANS; HYDROXYINDOLEACETIC ACID; HYPERTHERMIA, INDUCED; INJECTIONS, INTRAPERITONEAL; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; TELEMETRY; TIME FACTORS;

EID: 56349093770     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1258-9     Document Type: Article

References (42)

1. M Attia 1984 Thermal pleasantness and temperature regulation in man Neurosci Biobehav Rev 8 335 342
2. LA Badon A Hicks K Lord BA Ogden S Meleg-Smith KJ Varner 2002 Changes in cardiovascular responsiveness and cardiotoxicity elicited during binge administration of ecstasy J Pharmacol Exp Ther 302 898 907
3. S Bexis BD Phillis J Ong JM White RJ Irvine 2004 Baclofen prevents MDMA-induced rise in core body temperature in rats Drug Alcohol Depend 74 89 96
4. D Bhaskaran E Radha 1984 Circadian variations in the monoamine levels and monoamine oxidase activity in different regions of the rat brain as a function of age Exp Gerontol 19 153 170
5. TM Cabrera-Vera F Garcia W Pinto G Battaglia 2000 Neurochemical changes in brain serotonin neurons in immature and adult offspring prenatally exposed to cocaine Brain Res 870 1 9
6. PD Callaghan K Farrand A Salem P Hughes LC Daws RJ Irvine 2006 Repeated administration of the substituted amphetamine p-methoxyamphetamine produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine Eur J Pharmacol 546 74 81
7. JB Chambers TD Williams A Nakamura RP Henderson JM Overton ME Rashotte 2000 Cardiovascular and metabolic responses of hypertensive and normotensive rats to one week of cold exposure Am J Physiol Regul Integr Comp Physiol 279 R1486 R1494
8. KJ Clemens PS Van Nieuwenhuyzen KM Li JL Cornish GE Hunt IS McGregor 2004 MDMA ("ecstasy"), methamphetamine and their combination: long-term changes in social interaction and neurochemistry in the rat Psychopharmacology (Berl) 173 318 325
9. KJ Clemens JL Cornish GE Hunt IS McGregor 2007 Repeated weekly exposure to MDMA, methamphetamine or their combination: long-term behavioural and neurochemical effects in rats Drug Alcohol Depend 86 183 190
10. MI Colado R Granados E O'Shea B Esteban AR Green 1998 Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR Br J Pharmacol 124 479 484
11. RI Dafters 1995 Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing Physiol Behav 58 877 882
12. M Florez-Duquet E Peloso E Satinoff 2001 Fever and behavioral thermoregulation in young and old rats Am J Physiol Regul Integr Comp Phys 280 R1457 R1461
13. CJ Gordon 1987 Relationship between preferred ambient temperature and autonomic thermoregulatory function in rat Am J Physiol 252 R1130 R1137
14. CJ Gordon 1990 Thermal biology of the laboratory rat Physiol Behav 47 963 991
15. LR Gowing SM Henry-Edwards RJ Irvine RL Ali 2002 The health effects of ecstasy: a literature review Drug Alcohol Rev 21 53 63
16. AR Green AO Mechan JM Elliott E O'Shea MI Colado 2003 The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") Pharmacol Rev 55 463 508
17. AR Green E O'Shea MI Colado 2004 A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response Eur J Pharmacol 500 3 13
18. AR Green E O'Shea KS Saadat JM Elliott MI Colado 2005 Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures Br J Pharmacol 146 306 312
19. RJ Irvine J White R Chan 1997 The influence of restraint on blood pressure in the rat J Pharmacol Toxicol Methods 38 157 162
20. RJ Irvine M Keane P Felgate UD McCann PD Callaghan JM White 2006 Plasma drug concentrations and physiological measures in 'dance party' participants Neuropsychopharmacology 31 424 430
21. M Izco L Orio E O'Shea MI Colado 2007 Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain Psychopharmacology (Berl) 189 459 470
22. EJ Jaehne A Salem RJ Irvine 2005 Effects of 3,4- methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation Pharmacol Biochem Behav 81 485 496
23. EJ Jaehne A Salem RJ Irvine 2007 Pharmacological and behavioral determinants of cocaine, methamphetamine, 3,4-methylenedioxymethamphetamine, and para-methoxyamphetamine-induced hyperthermia Psychopharmacology (Berl) 194 41 52
24. SJ Lester M Baggott S Welm NB Schiller RT Jones E Foster J Mendelson 2000 Cardiovascular effects of 3,4-methylenedioxymethamphetamine. A double-blind, placebo-controlled trial Ann Intern Med 133 969 973
25. J Lyles JL Cadet 2003 Methylenedioxymethamphetamine (MDMA, ecstasy) neurotoxicity: cellular and molecular mechanisms Brain Res Brain Res Rev 42 155 168
26. JE Malberg LS Seiden 1998 Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat J Neurosci 18 5086 5094
27. UD McCann Z Szabo U Scheffel RF Dannals GA Ricaurte 1998 Positron emission tomographic evidence of toxic effect of MDMA ("ecstasy") on brain serotonin neurons in human beings Lancet 352 1433 1437
28. SJ McDougall AJ Lawrence RE Widdop 2005 Differential cardiovascular responses to stressors in hypertensive and normotensive rats Exp Physiol 90 141 150
29. AO Mechan E O'Shea JM Elliott MI Colado AR Green 2001 A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation Psychopharmacology (Berl) 155 413 418
30. JM Miguez M Aldegunde L Paz-Valinas J Recio E Sanchez-Barcelo 1999 Selective changes in the contents of noradrenaline, dopamine and serotonin in rat brain areas during aging J Neural Transm 106 1089 1098
31. MS Morishima CC Gale 1972 Relationship of blood pressure and heart rate to body temperature in baboons Am J Physiol 223 387 395
32. E O'Shea R Granados B Esteban MI Colado AR Green 1998 The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy') Neuropharmacology 37 919 926
33. AC Parrott 2002 Recreational ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity Pharmacol Biochem Behav 71 837 844
34. AC Parrott J Rodgers T Buchanan J Ling T Heffernan AB Scholey 2006 Dancing hot on ecstasy: physical activity and thermal comfort ratings are associated with the memory and other psychobiological problems reported by recreational MDMA users Hum Psychopharmacol 21 285 298
35. V Sanchez E O'Shea KS Saadat JM Elliott MI Colado AR Green 2004 Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones J Psychopharmacol 18 412 416
36. GR Screaton M Singer HS Cairns A Thrasher M Sarner SL Cohen 1992 Hyperpyrexia and rhabdomyolysis after MDMA ("ecstasy") abuse Lancet 339 677 678
37. DI Sessler 1997 Mild perioperative hypothermia N Engl J Med 336 1730 1737
38. M Shankaran GA Gudelsky 1999 A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration Psychopharmacology (Berl) 147 66 72
39. United Nations Office on Drugs and Crime (2003) Ecstasy and amphetamines global survey 2003. United Nations, New York
40. ND Volkow L Chang GJ Wang JS Fowler M Leonido-Yee D Franceschi MJ Sedler SJ Gatley R Hitzemann YS Ding J Logan C Wong EN Miller 2001 Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers Am J Psychiatry 158 377 382
41. X Wang MH Baumann H Xu RB Rothman 2004 3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein Synapse 53 240 248
42. S Williamson M Gossop B Powis P Griffiths J Fountain J Strang 1997 Adverse effects of stimulant drugs in a community sample of drug users Drug Alcohol Depend 44 87 94