Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures

British Journal of Pharmacology

Volumn 146, Issue 2, 2005, Pages 306-312

  Green, A Richard ^a,b   O'Shea, Esther ^c   Saadat, Kathryn S ^a   Elliott, J Martin ^a   Colado, M Isabel ^c  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

5 Hydroxytryptamine; Dopamine; Ecstasy; Hyperthermia; Hypothermia; MDMA; Neurotoxicity; Tail temperature; Thermoregulation

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; REMOXIPRIDE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BRAIN CORTEX LESION; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; HEAT LOSS; HIPPOCAMPUS; HYPERTHERMIA; LOW TEMPERATURE; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; ROOM TEMPERATURE; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE; BRAIN CHEMISTRY; DOPAMINE ANTAGONISTS; HALLUCINOGENS; HYPOTHERMIA; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTOXICITY SYNDROMES; NEUROTOXINS; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; REGIONAL BLOOD FLOW; SEROTONIN; TAIL; TEMPERATURE; VASODILATION;

EID: 30544451258     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706318     Document Type: Article

References (30)

1. BLIGH, J. (1979). The central neurology of mammalian thermoregulation. Neuroscience, 4, 1213-1236.
2. COLADO, M.I., O'SHEA, E., GRANADOS, R., MURRAY, T.K. & GREEN, A.R. (1997). In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br. J. Pharmacol., 121, 889-900.
3. COLADO, M.I., O'SHEA, E. & GREEN, A.R. (2004). Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function. Psychopharmacology, 173, 249-263.
4. CRONIN, M.J. (1976). p-Chlorophenylalanine hyperthermia in a warm environment: reversal with 5-hydroxytryptophan. Brain Res., 112, 194-199.
5. DAFTERS, R.I. (1994). Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') in rats. Psychopharmacology, 114, 505-508.
6. DAFTERS, R.I. (1995). Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption and chronic dosing. Physiol. Behav., 58, 877-882.
7. DAFTERS, R.I. & LYNCH, E. (1998). Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') but not by fenfluramine. Psychopharmacology, 138, 207-212.
8. GORDON, C.J., WATKINSON, W.P., O'CALLAGHAN, J.P. & MILLER, D.B. (1991). Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat. Pharmacol. Biochem. Behav., 14, 644-653.
9. GRANT, R.T. (1963). Vasodilatation and body warming in the rat. J. Physiol., 167, 311-317.
10. GREEN, A.R., MECHAN, A.O., ELLIOTT, J.M., O'SHEA, E. & COLADO, M.I. (2003). The pharmacology and clinical pharmacology of 3,4- methylenedioxymethamphetamine (MDMA 'Ecstasy'). Pharmacol. Rev., 55, 463-508.
11. GREEN, A.R., O'SHEA, E. & COLADO, M.I. (2004a). A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response. Eur. J. Pharmacol., 500, 3-13.
12. GREEN, A.R., SANCHEZ, V., O'SHEA, E., SAADAT, K.S., ELLIOTT, J.M. & COLADO, M.I. (2004b). Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology, 173, 264-269.
13. HJORTH, S. & CARLSSON, A. (1987). Postsynaptic dopamine (DA) receptor stimulator properties of the putative DA autoreceptor-selective agonist B-HT 920 uncovered by co-treatment with the D-1 agonist SK&F 38393. Psychopharmacology, 93, 534-537.
14. MALBERG, J.E. & SEIDEN, L.S. (1998). Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J. Neurosci., 18, 5086-5094.
15. MCCANN, U.D., SZABO, A., SCHEFFEL, U., DANNALS, R.F. & RICAURTE, G.A. (1998). Neurotoxic effects in human brains after use of 3,4- methylenedioxymethamphetamine ('Ecstasy') viewed by positron emission tomography. Lancet, 352, 1433-1437.
16. MECHAN, A.O., ESTEBAN, B., O'SHEA, E., ELLIOTT, J.M., COLADO, M.I. & GREEN, A.R. (2002). The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats. Br. J. Pharmacol., 135, 170-180.
17. MECHAN, A.O., O'SHEA, E., ELLIOTT, J.M., COLADO, M.I. & GREEN, A.R. (2001). A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long term defect in thermoregulation. Psychopharmacology, 155, 413-418.
18. MILLS, E.M., RUSYNIAK, D.E. & SPRAGUE, J.E. (2004). The role of the sympathetic nervous system and uncoupling proteins in the thermogenesis induced by 3,4-methylenedioxymethamphetamine. J. Mol. Med., 82, 787-799.
19. O'SHEA, E., ESCOBEDO, I., ORIO, L., SNACHEZ, V., NAVARRO, M., GREEN, A.R. & COLADO, M.I. (2005). Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology, (in press).
20. PEDERSEN, N.P. & BLESSING, W.W. (2001). Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits. J. Neurosci., 21, 8648-8654.
21. REID, W.D., VOLICER, L., SMOOKER, H., BEAVEN, M.A. & BRODIE, B.B. (1968). Brain amines and temperature regulation. Pharmacology, 1, 329-344.
22. ROMANOVSKY, A.A., IVANOV, A.I. & SHIMANSKY, Y.P. (2002). Ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J. Appl. Physiol., 92, 2667-2679.
23. SAADAT, K.S., O'SHEA, E., COLADO, M.I., ELLIOTT, J.M. & GREEN, A.R. (2005). The role of 5-HT in the impairment of thermoregulation in MDMA ('ecstasy')-pretreated rats. Psychopharmacology, 179, 884-890.
24. SANCHEZ, V., O'SHEA, E., SAADAT, K.S., ELLIOTT, J.M., COLADO, M.I. & GREEN, A.R. (2004). Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones. J. Psychopharmacol., 18, 412-416.
25. SCHIFANO, F. (2004). A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities. Psychopharmacology, 173, 242-248.
26. SPRAGUE, J.E., BANKS, M.L., COOK, V.J. & MILLS, E.M. (2003). Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy). J. Pharmacol. Exp. Ther., 305, 159-166.
27. 3-adrenoreceptor antagonists. Br. J. Pharmacol., 142, 667-670.
28. VERMA, A. & KULKARNI, K. (1993). Differential role of dopamine receptor subtypes in thermoregulation and stereotypic behaviour in naïve and reserpinized rats. Arch. Int. Pharmacodyn., 324, 17-32.
29. YEHUDA, S. & WURTMAN, R.J. (1972a). The effects of D-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperatures. Life Sci., 11, 851-859.
30. YEHUDA, S. & WURTMAN, R.J. (1972b). Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine. Nature, 240, 477-478.